Is TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE safe in cosmetics?
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE has a safety rating of "GOOD" in our database. EU status: prohibited. 10 toxicological study endpoint(s) are available in our database.
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE
Also known as: EINECS 278-355-8
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE (CAS 75980-60-8) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. NOAEL 75 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 75980-60-8 →
Cross-Vertical Regulatory Divergence
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H361, H411, H361f, H360Fd).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin Conditioning
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone
InChIKey
VFHVQBAGLAREND-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =100 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =100 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardHarmful / Irritant
Hazard Class and Category
Repr. 1B; Skin Sens. 1B
Hazard Statements
- H360Fd
- H317 May cause an allergic skin reaction
Inserted via ATP: ATP21
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 14-Jun-2023)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Toxic for reproduction (Article 57c)
Substance of Very High Concern (SVHC)
Included: 14-Jun-2023
Toxic for reproduction (Article 57c)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1731
(EU) 2025/877
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Artificial nail systems. Max: 5,0 %.
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Restricted · max 5,0 %
Additional Jurisdictional Restrictions (5)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| AU | restricted | - | gel nail polish |
| SA | banned | - | All cosmetics (previously restricted to artificial nails at 5%) |
| SA | banned | - | Artificial nail products (previously restricted to 5%) |
| BR | banned | - | - |
| UK | restricted | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 10.0% | - | - | SCCS/0149 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Hardener
Photosensitizers
Softener and conditioner
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE by CAS number or substance name.
Studies
32
Lowest NOAEL
0.033
Highest NOAEL
200
Units vary across source rows: mg/kg bw/day, mg/kg bw/d
SCCS Opinion
CIR Safety Assessment
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 10.0% | - | - |
Known Synonyms
EINECS 278-355-8
Chemical Function
Softener and conditioner
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561198
Frequently Asked Questions
Is TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE allowed in the EU?
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE do in cosmetics?
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 75980-60-8.
What is the NOAEL for TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE?
The NOAEL (No Observed Adverse Effect Level) for TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE is =50 mg/kg bw/d based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR Safety Assessment.
Is TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE used outside cosmetics?
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE have different safety status in cosmetics vs industrial chemicals?
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H361, H411, H361f, H360Fd).
Compliance Tools
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Substance Compliance
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MoS Calculator
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