NOAEL Studies Cosmetic Ingredient

Trimethylolpropane Diallyl Ether NOAEL Studies

INCI: TRIMETHYLOLPROPANE DIALLYL ETHER

CAS: 682-09-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9315; row=12578; data_type=In Vivo; mixture=Chemical; chemical_name=2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol; preferred_name=2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol; dtxsid=DTXSID7044976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044976; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_9316; row=12579; data_type=In Vivo; mixture=Chemical; chemical_name=2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol; preferred_name=2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol; dtxsid=DTXSID7044976; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044976; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =800 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb0e4b0a7c65d1ca65a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1894/7/6/2?documentUUID=79a92109-ab98-4b02-95f3-de819faf96b2; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835367_15835369:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af940421beb3d19eec7fe112dfddc131
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb0e4b0a7c65d1ca65a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1894/7/6/2?documentUUID=79a92109-ab98-4b02-95f3-de819faf96b2; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835367_15835369:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd1a07be37d5dba570b3fc89d44717e4
ToxValDB_ECHA_IUCLID NOAEL =800 mg/kg bw/day Rat oral short-term; 30 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb0e4b0a7c65d1ca65d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1894/7/6/2?documentUUID=79a92109-ab98-4b02-95f3-de819faf96b2; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15838683:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5fe0f87095f21fcee528db84a9481b87
ToxValDB_ECHA_IUCLID NOEL =50 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb0e4b0a7c65d1ca65a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1894/7/6/2?documentUUID=79a92109-ab98-4b02-95f3-de819faf96b2; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15835368:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6e5780c587d2e298617aed3afc9a98a0
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630096:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b9ae41f09440e2f3bc95d92be6c07ddd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier Q58WDK0444 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q58WDK0444"}
openFDA substances FDA UNII substance identifier Q58WDK0444 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q58WDK0444"}
openFDA substances FDA UNII substance identifier Q58WDK0444 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q58WDK0444"}
openFDA substances FDA UNII substance identifier Q58WDK0444 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q58WDK0444"}