NOAEL Studies Cosmetic Ingredient

Trimethylolpropane NOAEL Studies

INCI: TRIMETHYLOLPROPANE

CAS: 77-99-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >=700 mg/m3 Rat inhalation - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/3/3?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15799352_15799353:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4abdbf4e17370f5d2e85096717f44f9
ToxValDB_ECHA_IUCLID LEL ~1180 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/6/3?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15827659:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d2928418c8405b308ed160dc531838e
ToxValDB_ECHA_IUCLID LEL <=2000 mg/m3 Rat inhalation - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/3/3?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15799352_15799353:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c71724c9889d9f4197676c1803714c1
ToxValDB_ECHA_IUCLID LEL ~7000 mg/kg bw/day Rat oral short-term; 12 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd7e4b0a7c65d227bac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/6/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15841209:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a2d29a1e55e4f92b133db6c0f89914f
ToxValDB_ECHA_IUCLID NOAEC ~19.2072 mg/m3 Rat inhalation short-term; 15 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/6/3?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15828748:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_77f2030612f302c42c18d8dad5c8bb48
ToxValDB_ECHA_IUCLID NOAEC ~130 mg/m3 Rat inhalation chronic; 3.5 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/6/3?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15829102:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31c68e3c1d6d45d9220b078d6dc1d52a
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral subchronic (developmental) reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaef0e4b0a7c65d1cbc6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/6/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15847210:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9dca7245052aecc307a8bdaeef0253fd
ToxValDB_ECHA_IUCLID NOAEL =450 mg/kg bw/day Rabbit oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/9/3?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15823582:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5c5fdf39348909045f795b46062981d7
ToxValDB_ECHA_IUCLID NOAEL =740 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c588; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/9/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15855065:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60e980b2b70f927c540946d423e2e0fc
ToxValDB_ECHA_IUCLID NOAEL =800 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/9/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860990_15861211:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f4dc314444ef6e7c171d0ae6848b107
ToxValDB_ECHA_IUCLID NOAEL =2200 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c588; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/9/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855954_15856651_15857160:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40d0b2eb4779baa502c153b7249084d7
ToxValDB_ECHA_IUCLID NOAEL ~3000 mg/kg bw/day Rat oral chronic; 5 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaef0e4b0a7c65d1cbc6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/6/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15849874:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3fafb062986b1892944178853f8dccaa
ToxValDB_ECHA_IUCLID NOAEL >6000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c593; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/9/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855954_15856651_15857160:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8080f613a91d7b7b8a77ea70b6920c2
ToxValDB_ECHA_IUCLID NOAEL =6600 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c588; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/9/2?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855954_15856651_15857160:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9877b20d118a1f89d5e78608c5357b8b
ToxValDB_ECHA_IUCLID NOEL =100 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15407/7/9/3?documentUUID=50fc1cfe-bc54-4712-a4da-c291a8a8f9ef; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15825176:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fdb6a1570208a4007a343515874026cf
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =3.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635408:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fbad4112ecc1840904fa86fdd43b3bec
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 090GDF4HBD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"090GDF4HBD"}
openFDA substances FDA UNII substance identifier 090GDF4HBD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"090GDF4HBD"}
openFDA substances FDA UNII substance identifier 090GDF4HBD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"090GDF4HBD"}
openFDA substances FDA UNII substance identifier 090GDF4HBD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"090GDF4HBD"}