Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Trimethylolpropane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.0299999993294 % | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 0.10000000149 % | oral | rat | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
None significant at cosmetic-use levels; primarily a building-block alcohol
Frequently Asked Questions
Is Trimethylolpropane safe in cosmetics?
None significant at cosmetic-use levels; primarily a building-block alcohol The EU classifies Trimethylolpropane as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Trimethylolpropane allowed in the EU?
Trimethylolpropane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylolpropane do in cosmetics?
Trimethylolpropane functions as: Humectant, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 77-99-6.
What is the Margin of Safety for Trimethylolpropane?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trimethylolpropane?
The NOAEL (No Observed Adverse Effect Level) for Trimethylolpropane is 0.0299999993294 % based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Trimethylolpropane compliance across multiple jurisdictions:
Related Ingredients
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