Tris Buffered Saline

INCI: TRIS BUFFERED SALINE (LISTED IN COSING)

CAS Number
Component-based: Tris (tromethamine) = 77-86-1; NaCl = 7647-14-5
Function
Buffering agent, pH adjuster — maintains formulation pH stability
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; TRIS/tromethamine is widely used in FDA-regulated products including OTC drugs

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

✅ Clean profile. Maintains color stability and ingredient activity in formulations. Well-established safety in pharma and cosmetics

⚠️
Concern Level: None

Frequently Asked Questions

Is Tris Buffered Saline safe in cosmetics?

✅ Clean profile. Maintains color stability and ingredient activity in formulations. Well-established safety in pharma and cosmetics The EU classifies Tris Buffered Saline as "permitted". Safety rating: EXCELLENT.

Is Tris Buffered Saline allowed in the EU?

Tris Buffered Saline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tris Buffered Saline do in cosmetics?

Tris Buffered Saline functions as: Buffering agent, pH adjuster — maintains formulation pH stability. It is classified as a cosmetic ingredient in our database. CAS number: Component-based: Tris (tromethamine) = 77-86-1; NaCl = 7647-14-5.

What is the Margin of Safety for Tris Buffered Saline?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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