Good Cosmetic Ingredient

Trisiloxane

INCI: TRISILOXANE

CAS Number
Insufficient Data
Function
Inactive excipient in topical drugs/cosmetics
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Functions as inactive cosmetic excipient; no OTC monograph listing as active ingredient. No GRASE classification (not a sunscreen active). No specific FDA restrictions identified. Note: drometrizole trisiloxane is a distinct UV filter substance — not to be conflated with Trisiloxane CAS 107-51-7.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Trisiloxane (CAS 107-51-7) is a volatile silicone conditioning and anti-foaming agent with a strong safety profile based on class-based read-across data. No Annex restriction in EU Regulation 1223/2009, no SCCS opinion, and no FDA restriction as a cosmetic excipient. Low dermal absorption (1%), no irritation, no sensitization, and negative genotoxicity/carcinogenicity findings for closest analogues. Generally considered safe at typical cosmetic use levels.

⚠️
Concern Level: Low

Regulatory Flags

eu-unrestricted no-sccs-opinion no-cir-review non-sensitizing

Frequently Asked Questions

Is Trisiloxane safe in cosmetics?

Trisiloxane (CAS 107-51-7) is a volatile silicone conditioning and anti-foaming agent with a strong safety profile based on class-based read-across data. No Annex restriction in EU Regulation 1223/2009, no SCCS opinion, and no FDA restriction as a cosmetic excipient. Low dermal absorption (1%), no irritation, no sensitization, and negative genotoxicity/carcinogenicity findings for closest analogues. Generally considered safe at typical cosmetic use levels. The EU classifies Trisiloxane as "permitted". Safety rating: GOOD.

Is Trisiloxane allowed in the EU?

Trisiloxane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trisiloxane do in cosmetics?

Trisiloxane functions as: Inactive excipient in topical drugs/cosmetics. It is classified as a Cosmetic Ingredient in our database. CAS number: Insufficient Data.

What is the Margin of Safety for Trisiloxane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Trisiloxane compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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