Poor Cosmetic Ingredient GHS Classified

Tris(Nonylphenyl)phosphite

INCI: TRIS(NONYLPHENYL)PHOSPHITE (TNPP)

CAS Number
26523-78-4
Function
Antioxidant/stabilizer — primarily industrial (polymer stabilizer), not a typical cosmetic ingredient
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically regulated for cosmetics; no GRAS status

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
WARNING
Pictograms
excl mark;warn; enviro;aqua
Hazard Statements
May cause allergic skin reaction Very toxic to aquatic life with long lasting effects
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.

Expert Verdict

🚨🚨 DO NOT USE IN COSMETICS. SVHC on ECHA Candidate List. Endocrine disruptor (environmental + human health concern). Releases 4-nonylphenol (estrogenic). Classified Repr. 2 (suspected reproductive toxicant). Aquatic Acute 1 + Chronic 1. ANSES evaluation ongoing for further restriction. Incompatible with any clean beauty, COSMOS, or ECOCERT standard

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Concern Level: High

Frequently Asked Questions

Is Tris(Nonylphenyl)phosphite safe in cosmetics?

🚨🚨 DO NOT USE IN COSMETICS. SVHC on ECHA Candidate List. Endocrine disruptor (environmental + human health concern). Releases 4-nonylphenol (estrogenic). Classified Repr. 2 (suspected reproductive toxicant). Aquatic Acute 1 + Chronic 1. ANSES evaluation ongoing for further restriction. Incompatible with any clean beauty, COSMOS, or ECOCERT standard The EU classifies Tris(Nonylphenyl)phosphite as "permitted". Safety rating: POOR.

Is Tris(Nonylphenyl)phosphite allowed in the EU?

Tris(Nonylphenyl)phosphite EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tris(Nonylphenyl)phosphite do in cosmetics?

Tris(Nonylphenyl)phosphite functions as: Antioxidant/stabilizer — primarily industrial (polymer stabilizer), not a typical cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 26523-78-4.

What is the Margin of Safety for Tris(Nonylphenyl)phosphite?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Tris(Nonylphenyl)phosphite classified as hazardous under GHS?

Tris(Nonylphenyl)phosphite carries a GHS signal word of "WARNING". Hazard statements: May cause allergic skin reaction Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

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