Good Cosmetic Ingredient NOAEL Data

Valeriana Officinalis Rhizome Extract

INCI: VALERIANA OFFICINALIS RHIZOME EXTRACT

CAS Number
8057-49-6
Function
Skin Conditioning, Soothing
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Permitted for cosmetic use; not separately restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Valeriana Officinalis Rhizome Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 18600 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 3100 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 18600 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 3100 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

None significant at cosmetic-use concentrations; well-established safety profile within the *V. officinalis* family

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Concern Level: Low

Regulatory Flags

plant-extract fda_food_additive

Frequently Asked Questions

Is Valeriana Officinalis Rhizome Extract safe in cosmetics?

None significant at cosmetic-use concentrations; well-established safety profile within the *V. officinalis* family The EU classifies Valeriana Officinalis Rhizome Extract as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Valeriana Officinalis Rhizome Extract allowed in the EU?

Valeriana Officinalis Rhizome Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Valeriana Officinalis Rhizome Extract do in cosmetics?

Valeriana Officinalis Rhizome Extract functions as: Skin Conditioning, Soothing. It is classified as a cosmetic ingredient in our database. CAS number: 8057-49-6.

What is the Margin of Safety for Valeriana Officinalis Rhizome Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Valeriana Officinalis Rhizome Extract?

The NOAEL (No Observed Adverse Effect Level) for Valeriana Officinalis Rhizome Extract is 18600 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.

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