NOAEL Studies
Cosmetic Ingredient
Vinyl Acetate NOAEL Studies
INCI: VINYL ACETATE
CAS: 108-05-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =29.9996 | mg/m3 | Rat (Crl:CD(SD)BR Sprague-Dawley; M/F) | inhalation | chronic; 104 weeks | chronic | ATSDR MRLs; row_hash=662dd4bc00e67652; source_hash=ToxValhc_f254c4ef830324c978945d7b2df263af; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=8.52; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e |
| Regulatory source | NOAEL | =76.0554 | mg/m3 | Rat (Sprague-Dawley (Crl:CD BR); M) | inhalation | short-term; 4 weeks | short-term | ATSDR MRLs; row_hash=32f68daf24ca8d9d; source_hash=ToxValhc_518fbdf38f4e067f7bb8fd573bb721fa; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=21.6; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; doi=10.1080/089583797198178; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e |
| Regulatory source | NOAEL | =102.463 | mg/m3 | Rat (Sprague-Dawley (Crl:CD BR); M) | inhalation | short-term; 5 days | short-term | ATSDR MRLs; row_hash=71c7d711c98c9986; source_hash=ToxValhc_e8d4dbd5f59d030ac44342a20d50d71b; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=29.1; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; doi=10.1080/089583797198178; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e |
| Regulatory source | NOAEL | =173.941 | mg/m3 | Rat (Crl:CD(SD)BR Sprague-Dawley; M/F) | inhalation | chronic; 104 weeks | chronic | ATSDR MRLs; row_hash=9964306e706e3da1; source_hash=ToxValhc_a4d8d64b67d983ceb47f444991c80877; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=49.4; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e |
| Regulatory source | NOAEL | =702.808 | mg/m3 | Rat (Sprague-Dawley (Crl:CD BR); M) | inhalation | short-term; 5 days | short-term | ATSDR MRLs; row_hash=df78d1e86ebaefd0; source_hash=ToxValhc_27e6d8afa848e7ac2d885ccb1eda385e; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=199.6; raw_unit=ppm; method=whole body; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; doi=10.1080/089583797198178; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e |
| Regulatory source | NOAEL (HEC) | =5 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=07eceed9ba0678cb; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 5 mg/m^3; system=Nervous, Respiratory; basis=Nasal epithelial lesions; point_of_departure=NOAEL (HEC): 5 mg/m^3; composite_uf=30; confidence=High; dtxsid=DTXSID3021431; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; rfc_last_updated=10/01/1990; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0512_summary.pdf |
| Regulatory source | RfC | =0.2 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=91894804a2e98e67; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=2e-1; system=Nervous, Respiratory; basis=Nasal epithelial lesions; point_of_departure=NOAEL (HEC): 5 mg/m^3; composite_uf=30; confidence=High; dtxsid=DTXSID3021431; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; rfc_last_updated=10/01/1990; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0512_summary.pdf |
California Proposition 65 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 2025-01-03 | California Proposition 65 listing | - |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 1995 | IARC Monographs | - |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 11.3941 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1935; Record_ID=acute_inhalation_1907; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.3941; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431 |
| NTP ICE acute inhalation | LC50 | 11.4 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1934; Record_ID=acute_inhalation_1131; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.4; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431 |
| NTP ICE acute inhalation | LC50 | 12.9495 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1936; Record_ID=acute_inhalation_1906; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.9495; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=3697; Record_ID=cancer_4253; Data_Type=WOE; Formulation_Name=Vinyl acetate; Mixture=Chemical; DTXSID=DTXSID3021431; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/81; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021431; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021431 |
ToxValDB ATSDR MRLs 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | MRL | =1.05632 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2023; ORIGINAL_YEAR=2023; TOXICOLOGICAL_EFFECT=respiratory in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447307_15447308_15447309:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aeed14b05be08d0042a5aceb85d268e2 |
| ToxValDB ATSDR MRLs | MRL | =2.46476 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2023; ORIGINAL_YEAR=2023; TOXICOLOGICAL_EFFECT=respiratory in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447307_15447308_15447309:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_30e8a0ea9db002d07981750e518eb9fc |
| ToxValDB ATSDR MRLs | MRL | =3.52108 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2023; ORIGINAL_YEAR=2023; TOXICOLOGICAL_EFFECT=respiratory in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447307_15447308_15447309:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89c2ebc36833ec2b045550a7772e9874 |
| ToxValDB ATSDR MRLs | NOAEL | =173.941 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447892_15447893:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a4d8d64b67d983ceb47f444991c80877 |
| ToxValDB ATSDR MRLs | NOAEL | =702.808 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | LONG_REF=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; TITLE=Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium; AUTHOR=Bogdanffy MS; DOI=10.1080/089583797198178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447888_15447889:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_27e6d8afa848e7ac2d885ccb1eda385e |
| ToxValDB ATSDR MRLs | NOAEL (HEC) | =29.9996 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Bogdanffy MS, Dreef-van der Meulen HC, Beems RB, et al. 1994a. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam Appl Toxicol 23(2):215-229. http://doi.org/10.1006/faat.1994.1100. ; Hazleton. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse (Vol. I, II, IV & Vol. I of Amendment to final report, with cover letter 01/31/89). The Society of the Plastics Industry Inc. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8e. OTS0510582. 890000088. 8EHQ01890642.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447892_15447893:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f254c4ef830324c978945d7b2df263af |
| ToxValDB ATSDR MRLs | NOAEL (HEC) | =76.0554 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; TITLE=Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium; AUTHOR=Bogdanffy MS; DOI=10.1080/089583797198178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447890_15447891:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_518fbdf38f4e067f7bb8fd573bb721fa |
| ToxValDB ATSDR MRLs | NOAEL (HEC) | =102.463 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | LONG_REF=Bogdanffy MS, Gladnick NL, Kegelman T, et al. 1997. Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium. Inhal Toxicol 9(4):331-350. http://doi.org/10.1080/089583797198178.; TITLE=Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium; AUTHOR=Bogdanffy MS; DOI=10.1080/089583797198178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp59.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447888_15447889:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8d4dbd5f59d030ac44342a20d50d71b |
ToxValDB Alaska DEC 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfC | =0.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445766:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=24368685d65971b1bb6db2a319e5b848 |
| ToxValDB Alaska DEC | RfD | =0.0571 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445765:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0d55feb0e4a3cda5328e199f2a377bb6 |
| ToxValDB Alaska DEC | RfD | =0.65 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445767:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ea88a7db2c9d8c8045c38063e7dfc21f |
| ToxValDB Alaska DEC | RfD | =1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445768:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=1d366f6aa7a3591f2fb9881035a9a081 |
ToxValDB Cal OEHHA REL derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =176.054 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Bogdanffy MS, Dreef-van Der Meulen HC, Beems RB, Feron VJ, Cascier TC, Tyler TR, Vinegar MB, and Rickard RW. 1994. Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse. Fundam. Appl. Toxicol. 23:215-229.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Histological lesions of the nasal epithelium; STUDY_GROUP=Cal OEHHA REL derivations:15952155:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_17e5e807e8ce154a1c9d3bb891c8f0fe |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =91548.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15521049:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b0a36bc2bb72109577e824960b7d723 |
ECHA 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | BMDL (10) | =477 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818451_15818452_15820281:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_80ec17d33b8078d42311c477c2dc0019 |
| ECHA | LEL | =14084.3 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/3/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15798173:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60a5efc9933e74aab841dd0e37d3d8a7 |
| ECHA | LOAEL | =3521.08 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ed97; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821451:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9b1a35d04f6ed79098cc7db2c11c101b |
| ECHA | NOAEC | =176.054 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828467_15828468:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7880f95d71c58f84f961f103f0d50eed |
| ECHA | NOAEC | =528.162 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828931_15829289:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_128d0292401093c45c0bcc4b3e3e51e8 |
| ECHA | NOAEC | =704.216 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215eea; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15816145:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41ac8be65c32710b4bcfec1b75e10f71 |
| ECHA | NOAEL | =98 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ff9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850319:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_218d3f50c7dc80c6949bb797395ec30a |
| ECHA | NOAEL | >=100 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823291:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ba00594a771e67286d62d304d8a15054 |
| ECHA | NOAEL | =146 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ff9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850318:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ef52908db2310b6b32aa8a4bc013bfb |
| ECHA | NOAEL | =202 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850315:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_531986b5da42a8bda5f777e110af69ba |
| ECHA | NOAEL | =223 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818016_15820285:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e18ce76b5120930186bcba2c38efec01 |
| ECHA | NOAEL | =281 | mg/kg bw/day | Mouse | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15847505:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_152ab67e5ffa890378fc6d63c81901c0 |
| ECHA | NOAEL | =285 | mg/kg bw/day | Mouse | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15848713:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6bbdfeb0d79b2b10561d29a290fc2a20 |
| ECHA | NOAEL | =301 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15850316:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_38f1143d8dee0e95f934ab52c02b7765 |
| ECHA | NOAEL | =684 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15848595:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3c06fa7b4610aa74f18651af1fbaea5d |
| ECHA | NOAEL | =760 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15847904:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_365597123c563dcfe1048776ddff6b5b |
| ECHA | NOAEL | =810 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15847271:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8f941e944e66ab7d97adbfbbf21a4d27 |
| ECHA | NOAEL | =1000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c891e4b0a7c65d21915e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15857252:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_675a92045dac9221e404dd99d13e33df |
| ECHA | NOAEL | =1260 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816630_15820283:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1983122464efe1ef4face21f50a1504d |
| ECHA | NOAEL | =1325 | mg/kg bw/day | Mouse | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e29; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/2?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15848541:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4592bcc861908ae48021dd754d3679bb |
| ECHA | NOAEL | >=5000 | ppm | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22eefc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/9/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15821672:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87206e3eddb424c50002b9a1e378e75d |
| ECHA | NOAEL | =5352 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818016_15820285:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1a747d43971cc83bbefc9186d39e28a0 |
| ECHA | NOAEL | =6048 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cd2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816630_15820283:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_207d1d9df70c2831acefe31e35fe55ed |
| ECHA | NOEC | =176.054 | mg/m3 | Mouse | inhalation | acute; 6 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/6/3?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827556_15827557_15828943:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a526b3b7506248a003df7f1dfb28e843 |
| ECHA | NOEL | =1115 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2cda; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15530/7/8?documentUUID=07a4573b-fdbe-4e07-a241-5c26d0280c8e; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818451_15818452_15820281:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9eb40883cac2ae7376fc640044a4b316 |
EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | BMDL (10) | =440 | mg/kg bw/day | Mouse | oral | - | chronic | LONG_REF=EFSA ANS (2013). Scientific Opinion on the safety of polyvinyl alcohol-polyethylene glycol-graft-co-polymer as a food additive. doi:10.2903/j.efsa.2013.3303.; TITLE=Scientific Opinion on the safety of polyvinyl alcohol-polyethylene glycol-graft-co-polymer as a food additive.; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2013.3303; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15622538:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c11c056f160082f256c595514230bbc9 |
ToxValDB EPA TSCA 8e 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =250 | mg/kg bw/day | Rabbit | oral | acute | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21160_Combined.pdf; TOXICOLOGICAL_EFFECT=decreased food consumption, decreased body weight, stomach foci; STUDY_GROUP=EPA TSCA 8e_dup_-_15956621_15956622:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8b67a366271f38f18e68b9da606d6707 |
| ToxValDB EPA TSCA 8e | LEL | =500 | mg/kg bw/day | Rabbit | oral | acute | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21160_Combined.pdf; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EPA TSCA 8e_dup_-_15956621_15956622:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e3daa74c4d63de93c59a0d00e60ff3d7 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | NOAEL | =35.2108 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=ACGIH (1992) Vinyl acetate. In: Documentation of Threshold Limit Values and Biological Exposure Indices, 6th Edition. American Conference of Governmental Industrial Hygienists, Cincinnatti, OH.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d35a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/093_vinyl_acetate_oel_en.pdf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=irritancy; STUDY_GROUP=EU SCOEL:15952578:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5811464380e67b0c36d28d88598a78a7 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =17.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635668_15635669:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e9dc0039ec81d81329fcbc5efe8e08f8 |
ToxValDB IRIS 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =704 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_063412a42f23c450e182b454153f7b4a |
| ToxValDB IRIS | LOAEL (ADJ) | =126 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_29f80d6c623b81545be8c9d57744e390 |
| ToxValDB IRIS | LOAEL (HEC) | =19 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5b80d4f8ca65be667b366ba3e7341674 |
| ToxValDB IRIS | NOAEL | =176 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b6cb3223ebbc1062caffc8bd4d5d5c7b |
| ToxValDB IRIS | NOAEL (ADJ) | =31 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cf8d479957aa358ce2853c7f9248e81e |
| ToxValDB IRIS | NOAEL (HEC) | =5 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. ; Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ; Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b3b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=512; TOXICOLOGICAL_EFFECT=nasal epithelial lesions; STUDY_GROUP=IRIS_dup_IRIS Summary_15645547_15645548_15645549_15645550_15645551_15645552:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_adc967a6daff03ae5c8bbc7e9c37c4d6 |
ToxValDB TX TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =70.4216 | mg/m3 | Human | inhalation | acute; 240 minutes | clinical | LONG_REF=Smyth HF Jr, Carpenter CP. 1973; Vinyl acetate: Single animal inhalation and human sensory response. Carnegie Mellon University, Division of Sponsored Research, Chemical Hygiene Fellowship, Pittsburgh, PA. Special report f/36-72.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ab0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/vinylacetate.pdf; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=Persistent slight throat irritation; STUDY_GROUP=TX TCEQ:15954726:-:-volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d046ea66748dc479ddac9c1dce70389 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | L9MK238N77 | UNII | - | - | - | chemical | - |