Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Vinyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 ppm | oral | rat | oral | REACH |
| NOAEL | 5000 ppm | oral | mouse | oral | REACH |
| NOAEL | 1000 ppm | oral | rat | oral | REACH |
| NOAEL | 1000 ppm | oral | rat | oral | REACH |
| NOAEL | 24000 ppm | oral | mouse | oral | REACH |
| NOAEL | 98 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 202 mg/kg bw/day | oral | mouse | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Free monomer is IARC Group 2B (possibly carcinogenic). Ensure polymer-grade material with residual monomer < 1 ppm. Always request monomer residue COA
Regulatory Flags
Frequently Asked Questions
Is Vinyl Acetate safe in cosmetics?
Free monomer is IARC Group 2B (possibly carcinogenic). Ensure polymer-grade material with residual monomer < 1 ppm. Always request monomer residue COA The EU classifies Vinyl Acetate as "permitted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is Vinyl Acetate allowed in the EU?
Vinyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Vinyl Acetate do in cosmetics?
Vinyl Acetate functions as: Film forming (monomer used in copolymer synthesis). It is classified as a cosmetic ingredient in our database. CAS number: 108-05-4.
What is the Margin of Safety for Vinyl Acetate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Vinyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Vinyl Acetate is 5000 ppm based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Is Vinyl Acetate classified as hazardous under GHS?
Vinyl Acetate carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Toxic if inhaled May be harmful if swallowed or in contact with skin Suspected of causing cancer May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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