NOAEL Studies
Cosmetic Ingredient
Vinyl Chloride NOAEL Studies
INCI: VINYL CHLORIDE
CAS: 75-01-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =0.09 | mg/kg/day | Rat (Wistar; M/F) | oral | chronic; 149 weeks | chronic | ATSDR MRLs; row_hash=946d358bccf59a41; source_hash=ToxValhc_0b3fed0652fc4eed6abc0399b5c767d5; raw_endpoint_type=NOAEL (HED); raw_endpoint_subtype=; raw_value=0.09; raw_unit=mg/kg/day; method=diet; effect=liver cell polymorphisms; effect_category=nonneoplastic histopathology; file=toxval_ATSDR_MRLs.xlsx; long_ref=Til HP, Immel HR, Feron VJ. 1983. Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. Civo Institutes, TNO. Report No. V 93.285/291099. ; Til HP, Feron VJ, Immel HR. 1991. Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41 |
| Regulatory source | NOAEL | =0.17 | mg/kg/day | Rat (Wistar; M/F) | oral | chronic; 149 weeks | chronic | ATSDR MRLs; row_hash=5ff8b1750ff4aab2; source_hash=ToxValhc_4c7ac4976d7bbcff9d6741e4f428b753; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.17; raw_unit=mg/kg/day; method=diet; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Til HP, Immel HR, Feron VJ. 1983. Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. Civo Institutes, TNO. Report No. V 93.285/291099. ; Til HP, Feron VJ, Immel HR. 1991. Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41 |
| Regulatory source | NOAEL | =38.3438 | mg/m3 | Mouse (CF1; M/F) | inhalation | short-term (developmental); 10 days | developmental | ATSDR MRLs; row_hash=adb2b5ac690b5b41; source_hash=ToxValhc_b479e08e1bc3461c06727964ef45f10e; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=15; raw_unit=ppm; method=whole body; effect=developmental; effect_category=development; file=toxval_ATSDR_MRLs.xlsx; long_ref=John JA, Smith FA, Leong BKJ, et al. 1977. The effects of maternally inhaled vinyl chloride on embryonal and fetal development in mice, rats, and rabbits. Toxicol Appl Pharmacol 39:497-513. ; John JA, Smith FA, Schwetz BA. 1981. Vinyl chloride: Inhalation teratology study in mice, rats, and rabbits. Environ Health Perspect 41:171-177.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41 |
| Regulatory source | NOAEL | =127.812 | mg/m3 | Mouse (CF1; M/F) | inhalation | short-term (developmental); 10 days | developmental | ATSDR MRLs; row_hash=a2481df3b52112df; source_hash=ToxValhc_d5aab4aaf138e2565f1e453387dc13a5; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=50; raw_unit=ppm; method=whole body; effect=developmental; effect_category=development; file=toxval_ATSDR_MRLs.xlsx; long_ref=John JA, Smith FA, Leong BKJ, et al. 1977. The effects of maternally inhaled vinyl chloride on embryonal and fetal development in mice, rats, and rabbits. Toxicol Appl Pharmacol 39:497-513. ; John JA, Smith FA, Schwetz BA. 1981. Vinyl chloride: Inhalation teratology study in mice, rats, and rabbits. Environ Health Perspect 41:171-177.; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41 |
| Regulatory source | NOAEL (HEC) | =2.5 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=be656030d678a4d7; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 2.5 mg/m^3; system=Hepatic; basis=Liver cell polymorphism; point_of_departure=NOAEL (HEC): 2.5 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID8021434; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; rfc_last_updated=08/07/2000; rfc_pdf_url=https://iris.epa.gov/static/pdfs/1001_summary.pdf |
| Regulatory source | RfC | =0.1 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=2a0a74ee6499edcb; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=1e-1; system=Hepatic; basis=Liver cell polymorphism; point_of_departure=NOAEL (HEC): 2.5 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID8021434; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; rfc_last_updated=08/07/2000; rfc_pdf_url=https://iris.epa.gov/static/pdfs/1001_summary.pdf |
| Regulatory source | NOAEL (HED) | =0.09 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=26ba359093b47098; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HED): 9e-2 mg/kg-day; system=Hepatic; basis=Liver cell polymorphism; point_of_departure=NOAEL (HED): 9e-2 mg/kg-day; composite_uf=30; confidence=Medium; dtxsid=DTXSID8021434; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; rfd_last_updated=08/07/2000; rfd_pdf_url=https://iris.epa.gov/static/pdfs/1001_summary.pdf |
| Regulatory source | RfD | =0.003 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=d13caba522466a8d; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-3; system=Hepatic; basis=Liver cell polymorphism; point_of_departure=NOAEL (HED): 9e-2 mg/kg-day; composite_uf=30; confidence=Medium; dtxsid=DTXSID8021434; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; rfd_last_updated=08/07/2000; rfd_pdf_url=https://iris.epa.gov/static/pdfs/1001_summary.pdf |
California Proposition 65 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | LC3 | ug/day | - | - | 1987-02-27 | No significant risk level | - |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 1987-02-27 | California Proposition 65 listing | - |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 1 | IARC group | - | - | 2009 | IARC Monographs | - |
WHO/JECFA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | =0.13 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=e51e4ad3a11b2e18; raw_unit=mg/kg body weight; context=The NOAEL was 0.13 mg/kg body weight. |
| WHO/JECFA | NOAEL | =130 | mg/m3 | Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=6bb2f8246420e9fe; raw_unit=mg/m 3; context=Chez des rats et des souris exposés par la voie respiratoire la dose sans effet nocif observable (NOAEL) est inférieure à 130 mg/m 3 pour ce qui est des effets cancérogènes. |
| WHO/JECFA | NOAEL | =13 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=04037c11a7d1ff49; raw_unit=mg/kg; context=La NOAEL était égale à 0,13 mg/kg de poids corporel. |
| WHO/JECFA | NOEL | =30 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=19b1812db72bdb42; raw_unit=mg/kg body weight; context=The NOEL was given as 30 mg/kg body weight (Feron et al., 1975). |
| WHO/JECFA | NOEL | =130 | mg/m3 | Rat; Mouse | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=9ee89e720e50d7ab; raw_unit=mg/m 3; context=Thus NOEL for rats or mice concerning non-neoplastic effects could not be derived, since effects were observed at the lowest levels studied (130 mg/m 3 ). |
| WHO/JECFA | NOEL | range:0.5-55 | ppm | - | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=0440dbf54eec89ac; raw_unit=ppm; context=2.4 Storm & Rozman (1997) Storm & Rozman (1997) use a no-threshold (LMS model and benchmark dose approach with linear extrapolation) and threshold (NOEL/LOEL and benchmark dose uncertainty factor approaches) models and compare them with the present occupational exposure limits in the 0.5 to 5 ppm range (Table 59). |
| WHO/JECFA | NOEL | =13 | mg/m3 | Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=062a991f08326fb1; raw_unit=mg/m 3; context=A NOEL of 13 mg/m 3 (5 ppm) was derived from the Maltoni et al. (1981) bioassay in rats. |
| WHO/JECFA | NOEL | range:0.4-44 | ppm | Human; Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc215; title=Vinyl Chloride (EHC 215, 1999); path=mirror/documents/ehc/ehc/ehc215.htm; row_hash=103089d8b14306f0; raw_unit=ppm; context=Estimations based on the rat NOEL approach gave values of 0.4 to 4 ppm, respectively, for humans more and less sensitive than rats. |
| WHO/JECFA | NOAEL | =0.13 | mg/kg bw | Rat | - | - | Toxicology study | document_id=hsg_hsg_hsg109; title=Vinyl Chloride (HSG 109, 1999); path=mirror/documents/hsg/hsg/hsg109.htm; row_hash=361774c581e5ec9c; raw_unit=mg/kg body weight; context=In rats, liver cell polymorphism (variation in size and shape of hepatocytes and their nuclei) could be seen at levels as low as 1.3 mg/kg body weight, and the NOAEL was 0.13 mg/kg body weight. |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 383.1971 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4379; Record_ID=acute_inhalation_1829; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=383.1971; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE acute inhalation | LC50 | 390 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4378; Record_ID=acute_inhalation_679; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=390; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16163/7/3/3/?documentUUID=976994f1-38dd-4d17-8e1a-051c95413e48; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE acute inhalation | LC50 | 459.8365 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4380; Record_ID=acute_inhalation_2787; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=459.8365; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9979; row=13299; data_type=In Vivo; mixture=Chemical; chemical_name=Vinyl chloride; preferred_name=Vinyl chloride; dtxsid=DTXSID8021434; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 147.3 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3127; Record_ID=adme_parameters_1223; Data_Type=Measured; DTXSID=DTXSID8021434; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=147.3; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE adme parameters | Clint | 147.3 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=3128; Record_ID=adme_parameters_1223; Data_Type=Measured; DTXSID=DTXSID8021434; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=147.3; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE adme parameters | Fu | 0.4183 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=3129; Record_ID=adme_parameters_1223; Data_Type=Measured; DTXSID=DTXSID8021434; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.4183; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE adme parameters | Fu | 0.5924 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3130; Record_ID=adme_parameters_1223; Data_Type=Measured; DTXSID=DTXSID8021434; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.5924; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
NTP ICE cancer 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 1 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=9004; Record_ID=cancer_3654; Data_Type=WOE; Formulation_Name=Vinyl chloride; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=1; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/115; http://publications.iarc.fr/123; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE cancer | Inhalation risk unit | 0.0000044 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=9008; Record_ID=cancer_3656; Data_Type=WOE; Formulation_Name=Vinyl chloride; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=4.4000000000000002E-6; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/1001_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE cancer | Inhalation risk unit | 0.0000088 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=9009; Record_ID=cancer_3656; Data_Type=WOE; Formulation_Name=Vinyl chloride; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=8.8000000000000004E-6; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/1001_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE cancer | Oral slope factor | 0.72 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=9003; Record_ID=cancer_3657; Data_Type=WOE; Formulation_Name=Vinyl chloride; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=0.72; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/1001_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE cancer | Oral slope factor | 0.75 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=9012; Record_ID=cancer_3657; Data_Type=WOE; Formulation_Name=Vinyl chloride; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=0.75; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/1001_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE cancer | Oral slope factor | 1.4 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=9013; Record_ID=cancer_3657; Data_Type=WOE; Formulation_Name=Vinyl chloride; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=1.4; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/1001_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
| NTP ICE cancer | Oral slope factor | 1.5 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=9011; Record_ID=cancer_3657; Data_Type=WOE; Formulation_Name=Vinyl chloride; Mixture=Chemical; DTXSID=DTXSID8021434; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=1.5; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/1001_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021434 |
ToxValDB ATSDR MRLs 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | BMCL (10) | =5.24031 | mg/m3 | Rat | inhalation | chronic; 19 weeks | chronic | LONG_REF=Thornton SR, Schroeder RE, Robison RL, et al. 2002. Embryo-fetal developmental and reproductive toxicology of vinyl chloride in rats. Toxicol Sci 68:207-219.; TITLE=Embryo-fetal developmental and reproductive toxicology of vinyl chloride in rats; AUTHOR=Thornton SR; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp20.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447897:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b2b677d4c479339a61ab973e452acd62 |
| ToxValDB ATSDR MRLs | BMCL (HEC) | =1.27813 | mg/m3 | Rat | inhalation | chronic; 19 weeks | reproduction developmental | LONG_REF=Thornton SR, Schroeder RE, Robison RL, et al. 2002. Embryo-fetal developmental and reproductive toxicology of vinyl chloride in rats. Toxicol Sci 68:207-219.; TITLE=Embryo-fetal developmental and reproductive toxicology of vinyl chloride in rats; AUTHOR=Thornton SR; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp20.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ATSDR MRLs:15447896:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_66e2621899f5c877c190b8d78ed0fb42 |
| ToxValDB ATSDR MRLs | MRL | =0.051125 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=hepatic in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447310_15447311:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0bb267d8e07af34e519bd7e4d650c44e |
| ToxValDB ATSDR MRLs | MRL | =1.27813 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=developmental in male/female mice; STUDY_GROUP=ATSDR MRLs_dup_-_15447310_15447311:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c7db6e78130f70aa73997dcc1da9b5d |
| ToxValDB ATSDR MRLs | NOAEL | =0.17 | mg/kg bw/day | Rat | oral | chronic; 149 weeks | chronic | LONG_REF=Til HP, Immel HR, Feron VJ. 1983. Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. Civo Institutes, TNO. Report No. V 93.285/291099. ; Til HP, Feron VJ, Immel HR. 1991. Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp20.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs_dup_-_15447898_15447899:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4c7ac4976d7bbcff9d6741e4f428b753 |
| ToxValDB ATSDR MRLs | NOAEL | =127.812 | mg/m3 | Mouse | inhalation | short-term (developmental); 10 days | developmental | LONG_REF=John JA, Smith FA, Leong BKJ, et al. 1977. The effects of maternally inhaled vinyl chloride on embryonal and fetal development in mice, rats, and rabbits. Toxicol Appl Pharmacol 39:497-513. ; John JA, Smith FA, Schwetz BA. 1981. Vinyl chloride: Inhalation teratology study in mice, rats, and rabbits. Environ Health Perspect 41:171-177.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp20.pdf; TOXICOLOGICAL_EFFECT=developmental; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ATSDR MRLs_dup_-_15447894_15447895:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d5aab4aaf138e2565f1e453387dc13a5 |
| ToxValDB ATSDR MRLs | NOAEL (HEC) | =38.3438 | mg/m3 | Mouse | inhalation | short-term (developmental); 10 days | developmental | LONG_REF=John JA, Smith FA, Leong BKJ, et al. 1977. The effects of maternally inhaled vinyl chloride on embryonal and fetal development in mice, rats, and rabbits. Toxicol Appl Pharmacol 39:497-513. ; John JA, Smith FA, Schwetz BA. 1981. Vinyl chloride: Inhalation teratology study in mice, rats, and rabbits. Environ Health Perspect 41:171-177.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp20.pdf; TOXICOLOGICAL_EFFECT=developmental; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ATSDR MRLs_dup_-_15447894_15447895:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b479e08e1bc3461c06727964ef45f10e |
| ToxValDB ATSDR MRLs | NOAEL (HED) | =0.09 | mg/kg bw/day | Rat | oral | chronic; 149 weeks | chronic | LONG_REF=Til HP, Immel HR, Feron VJ. 1983. Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. Civo Institutes, TNO. Report No. V 93.285/291099. ; Til HP, Feron VJ, Immel HR. 1991. Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp20.pdf; TOXICOLOGICAL_EFFECT=liver cell polymorphisms; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ATSDR MRLs_dup_-_15447898_15447899:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b3fed0652fc4eed6abc0399b5c767d5 |
ToxValDB Alaska DEC 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfC | =0.1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445679:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=a118c046990d399f0da80e0906dca49a |
| ToxValDB Alaska DEC | RfD | =0.003 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445673:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=059b175766471c7f97bda9a4bb5e4495 |
| ToxValDB Alaska DEC | RfD | =0.0286 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445676:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=2c5d57d4464fc29b53c14037e36708d6 |
ToxValDB Cal OEHHA REL derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =667.181 | mg/m3 | Human | inhalation | acute; 7.5 hours | clinical | LONG_REF=Baretta ED, Stewart RD, Mutchler JE. Monitoring exposures to vinyl chloride vapor: breath analysis and continuous air sampling. Am Ind Hyg Assoc J 1969;30:537-544.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=subjective reports of mild headaches and dryness of eyes and nose (groups 2 and 3); no effects reported by group 1; STUDY_GROUP=Cal OEHHA REL derivations:15951989:-:-healthy volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_421f8aa6b66427ded450b90ea8e641a2 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =97137.5 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15521063:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25fafc832dab214c1ab2e8f737cf48ea |
ToxValDB DOE Wildlife Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =1.7 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511728_15511729:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_83794d4b2d62a90c8b17c91a2880aa63 |
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =0.17 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511728_15511729:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b3c81bc23ffb963c52c6d954e731e98 |
ECHA 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | >=255625 | mg/m3 | Guinea Pig | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61b50e4b096bca876d9e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/3/3?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15795691:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8ed2f5db8dcb3694ce0e520055604cc |
| ECHA | LOAEC | =127.812 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c836e4b0a7c65d217587; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/8?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15817036:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66721931343bec542d660a0e263dd9ed |
| ECHA | LOAEC | =12781.2 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c836e4b0a7c65d217595; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/8?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15817606:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f455e105168e52207c2ae10229d5767 |
| ECHA | LOAEC | =51125 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/3?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15827999:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_14309cfc17b8e0dfdc52a1e31d76f7b5 |
| ECHA | LOAEC | =127812 | mg/m3 | Rat | inhalation | short-term; 19 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/3?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15828815:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c4ce91102dfdd5a66bdd0ec861facb6 |
| ECHA | LOAEL | =1.7 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4493; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/8?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816779_15819358:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0616319054c0be561c231985d365027c |
| ECHA | LOEC | =260 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/3?documentUUID=a70bcddf-cbcf-4729-99fe-3edd966ec4ec; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827771_15827772:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac90f887f0d7112a9b42ee9cb3094d40 |
| ECHA | NOAEC | =25.5625 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c93ee4b0a7c65d21c2ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/9/2?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15857692:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd042431d19f46cb3a4c35e683531d4d |
| ECHA | NOAEC | =127.812 | mg/m3 | Rat | inhalation | acute; 4 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/3?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15829168:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b68f6a52cb34dc7b0dcedecca92ad810 |
| ECHA | NOAEC | =255.625 | mg/m3 | Rabbit | inhalation | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/3?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15828129:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5097211b35b18ca33f7e5f74190f05aa |
| ECHA | NOAEC | =511.25 | mg/m3 | Dog | inhalation | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/3?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15828207:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99a72105a12aad1f2a22ff4370557b71 |
| ECHA | NOAEC | =2811.88 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c93ee4b0a7c65d21c2ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/9/2?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15859644:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_95bb2dd423eede64d16a1c06f84fe380 |
| ECHA | NOAEL | =0.13 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4495; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/8?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816779_15819358:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_33f065ddb071fe7aa309567f0ec15f48 |
| ECHA | NOAEL | =30 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb7e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/2?documentUUID=6a149599-4c1c-4a66-8357-f9154b62598f; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=ECHA IUCLID:15842130:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2527a51c2144e3f790c1210cd452f9df |
| ECHA | NOEC | =130 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1841/7/6/3?documentUUID=a70bcddf-cbcf-4729-99fe-3edd966ec4ec; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827771_15827772:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e151596c87ec17aba4add307a68325a |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =25 | ppm | Mouse | oral | short-term; 3 days | short-term | LONG_REF=Toxicology249(2/3): 176-183 Eun,J.W., S.Y. Ryu, J.H. Noh, M.J. Lee, J.J. Jang, J.C. Ryu, K.H. Jung, J.K. Kim, H.J. Bae, H. Xie, S.Y. Kim, S.H. Lee, Discriminating the Molecular Basis of Hepatotoxicity Using the Large-Scale Characteristic Molecular Signatures of Toxicants by Expression Profiling Analysis 2008; TITLE=Discriminating the Molecular Basis of Hepatotoxicity Using the Large-Scale Characteristic Molecular Signatures of Toxicants by Expression Profiling Analysis; AUTHOR=Eun,J.W., S.Y. Ryu, J.H. Noh, M.J. Lee, J.J. Jang, J.C. Ryu, K.H. Jung, J.K. Kim, H.J. Bae, H. Xie, S.Y. Kim, S.H. Lee,; DOI=10.1016/j.tox.2008.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111454; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597101_15597102:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4a8fb281fc63c62440f141817b2fd0e0 |
| ToxValDB ECOTOX | NOEL | =50 | ppm | Mouse | oral | short-term; 3 days | short-term | LONG_REF=Toxicology249(2/3): 176-183 Eun,J.W., S.Y. Ryu, J.H. Noh, M.J. Lee, J.J. Jang, J.C. Ryu, K.H. Jung, J.K. Kim, H.J. Bae, H. Xie, S.Y. Kim, S.H. Lee, Discriminating the Molecular Basis of Hepatotoxicity Using the Large-Scale Characteristic Molecular Signatures of Toxicants by Expression Profiling Analysis 2008; TITLE=Discriminating the Molecular Basis of Hepatotoxicity Using the Large-Scale Characteristic Molecular Signatures of Toxicants by Expression Profiling Analysis; AUTHOR=Eun,J.W., S.Y. Ryu, J.H. Noh, M.J. Lee, J.J. Jang, J.C. Ryu, K.H. Jung, J.K. Kim, H.J. Bae, H. Xie, S.Y. Kim, S.H. Lee,; DOI=10.1016/j.tox.2008.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111454; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Biochemistry: Bilirubin|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597101_15597102:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6fde6be133a3a8697f9b321e882d981b |
ToxValDB HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =127.812 | mg/m3 | Mouse | inhalation | short-term; 10 days | reproduction developmental | LONG_REF=John, J. A. et al. (1977). Toxicol. Appl. Pharmacol., 39:497-513.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Jan. 31, 2007.; QUALITY=2; EXTERNAL_SOURCE_ID=59246; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642705:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f1d5e072e54624f8476de81981ab7ce7 |
| ToxValDB HPVIS | NOAEL | =1278.12 | mg/m3 | Mouse | inhalation | short-term; 10 days | developmental | LONG_REF=John, J. A. et al. (1977). Toxicol. Appl. Pharmacol., 39:497-513.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Jan. 31, 2007.; QUALITY=2; EXTERNAL_SOURCE_ID=58413; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642450:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce2687c254490e3ca7b3d2e05f1514fb |
| ToxValDB HPVIS | NOAEL | =6390.62 | mg/m3 | Rabbit | inhalation | short-term; 13 days | developmental | LONG_REF=John, J. A. et al. (1977). Toxicol. Appl. Pharmacol., 39:497-513.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Jan. 31, 2007.; QUALITY=2; EXTERNAL_SOURCE_ID=58416; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642453:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_178b682a16d4cb76f941a7d929a65b47 |
ToxValDB IRIS 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =1.3 | mg/kg bw/day | Rat | oral | chronic; 149 weeks | chronic | LONG_REF=Til, HP, Immel, HR, Feron, VJ. (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. CIVO Institutes. TNO Report No. V 83.285/291099, TSCATS Document FYI-AX-0184-0353, Fiche No. 0353. ; Til, HP, Feron, VJ, Immel, HR. (1991) Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a45e4b045b9ff7a5e66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; TOXICOLOGICAL_EFFECT=liver cell polymorphism; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15645545_15645558_15645559_15645560:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_465df7dbe186fa9f2728f6b7fe71c927 |
| ToxValDB IRIS | LOAEL (HEC) | =25.3 | mg/m3 | Rat | oral | - | chronic | LONG_REF=Til, HP, Immel, HR, Feron, VJ. (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. CIVO Institutes. TNO Report No. V 83.285/291099, TSCATS Document FYI-AX-0184-0353, Fiche No. 0353. ; Til, HP, Feron, VJ, Immel, HR. (1991) Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a45e4b045b9ff7a5e66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; TOXICOLOGICAL_EFFECT=liver cell polymorphism; STUDY_GROUP=IRIS_dup_IRIS Summary_15645563_15645564:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f6f03ea0696c5da0185691149b2c847f |
| ToxValDB IRIS | LOAEL (HED) | =0.9 | mg/kg bw/day | Rat | oral | chronic; 149 weeks | chronic | LONG_REF=Til, HP, Immel, HR, Feron, VJ. (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. CIVO Institutes. TNO Report No. V 83.285/291099, TSCATS Document FYI-AX-0184-0353, Fiche No. 0353. ; Til, HP, Feron, VJ, Immel, HR. (1991) Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a45e4b045b9ff7a5e66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; TOXICOLOGICAL_EFFECT=liver cell polymorphism; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15645545_15645558_15645559_15645560:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_590e1cb261a40cdf18c4e7da0321db81 |
| ToxValDB IRIS | NOAEL (HEC) | =2.5 | mg/m3 | Rat | oral | - | chronic | LONG_REF=Til, HP, Immel, HR, Feron, VJ. (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. CIVO Institutes. TNO Report No. V 83.285/291099, TSCATS Document FYI-AX-0184-0353, Fiche No. 0353. ; Til, HP, Feron, VJ, Immel, HR. (1991) Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a45e4b045b9ff7a5e66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; TOXICOLOGICAL_EFFECT=liver cell polymorphism; STUDY_GROUP=IRIS_dup_IRIS Summary_15645563_15645564:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5bb1f1bda9da2292b5007f3c4d5d02b6 |
| ToxValDB IRIS | RfC | =0.1 | mg/m3 | Human | oral | - | Toxicity Value | LONG_REF=Til, HP, Immel, HR, Feron, VJ. (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. CIVO Institutes. TNO Report No. V 83.285/291099, TSCATS Document FYI-AX-0184-0353, Fiche No. 0353. ; Til, HP, Feron, VJ, Immel, HR. (1991) Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a45e4b045b9ff7a5e66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001; TOXICOLOGICAL_EFFECT=Liver cell polymorphism in male/female rats; STUDY_GROUP=IRIS:15645565:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bac5292212ba265de17e58501e65f96b |
ToxValDB MN MDH HHBW 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB MN MDH HHBW | NOAEL | =10 | ppm | Rat | oral | - | repeat dose other | LONG_REF=U.S. Environmental Protection Agency (USEPA) - Integrated Risk Information System (IRIS). (2000a). IRIS Vinyl Chloride Assessment. Retrieved from https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=1001. U.S. Environmental Protection Agency (USEPA) - Integrated Risk Information System (IRIS). (2000b). Toxicological Review of Vinyl Chloride. Retrieved from https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/1001tr.pdf; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4ddd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/gw/vinylchloride.pdf; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Increased liver weight, hypertrophy, and hepatocellular foci; STUDY_GROUP=MN MDH HHBW:15952962:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2e5552f248258ae065a564ec63387eac |
ToxValDB TX TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | BMCL (10) | =6.953 | mg/m3 | Rat | inhalation | (developmental) | reproduction developmental | LONG_REF=Thornton SR, Schroeder RE, Robison RL, et al. 2002. Embryo-fetal developmental and reproductive toxicology of vinyl chloride in rats. Toxicol Sci 68:207-219.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ab3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/vinyl_chloride.pdf; YEAR=2009 Accessible 2013; ORIGINAL_YEAR=2009 Accessible 2013; TOXICOLOGICAL_EFFECT=Centrilobular hypertrophy in the liver; STUDY_GROUP=TX TCEQ:15954731:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_91f9d7a171143434453005ac6620ecde |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | WD06X94M2D | UNII | - | - | - | chemical | - |