NOAEL Studies
Cosmetic Ingredient
Xylene NOAEL Studies
INCI: XYLENE
CAS: 1330-20-7 (mixed isomers)
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=80a31e1b-e47f-40ba-b766-bafbf620e8ad_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=80a31e1b-e47f-40ba-b766-bafbf620e8ad/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=863bdcd2-4a5b-43d1-b6d1-7863cf993967 |
| ECHA | LOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=462ffc52-e87d-4224-9ea5-2ac898976f78_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=462ffc52-e87d-4224-9ea5-2ac898976f78/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=95eb4dbd-57a6-40bf-8cf8-477a21923134 |
| ECHA | LOAEL | >=100 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=b92efc94-1bc8-416f-be6b-8226a70b0345_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=b92efc94-1bc8-416f-be6b-8226a70b0345/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=clinical signs; key_result=true; entry_uuid=27ca51d8-8ad4-40d3-bdac-7051fe1af14f |
| ECHA | LOAEL | 600 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=9ded2699-0c07-4b85-8d00-1cb3593a51ac_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=9ded2699-0c07-4b85-8d00-1cb3593a51ac/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-10-22; basis=clinical signs; key_result=true; entry_uuid=219e166e-5c8d-4395-8356-20b122b7e75b |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=639b6d6b-0149-4896-8c4f-2f23bf7a7a1a_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=639b6d6b-0149-4896-8c4f-2f23bf7a7a1a/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-02-24; basis=clinical signs; key_result=true; entry_uuid=00fbed9b-5d8d-49b5-8226-8e39e26c6fc2 |
| ECHA | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=639b6d6b-0149-4896-8c4f-2f23bf7a7a1a_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=639b6d6b-0149-4896-8c4f-2f23bf7a7a1a/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-02-24; basis=behaviour (functional findings); key_result=true; entry_uuid=9c66da65-e8cb-469c-8f87-69ac656b11e7 |
| ECHA | NOAEL | >1000 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=04d9a4d1-daff-4ea1-a2e7-15e8668364b3_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=04d9a4d1-daff-4ea1-a2e7-15e8668364b3/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=94fdc0db-bf2b-47bc-87cb-a02cc388e7c6 |
| ECHA | NOAEL | >500 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=45d1468c-ed21-471f-b4da-e48657222b89_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=45d1468c-ed21-471f-b4da-e48657222b89/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=bb12633b-a569-40ef-b066-fffed978a5d6 |
| ECHA | NOAEL | ca.200 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=a0094fe2-7326-4fe6-b290-e22097bc8311_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=a0094fe2-7326-4fe6-b290-e22097bc8311/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-05-27; basis=body weight and weight gain; key_result=true; entry_uuid=f62fa61a-cea9-4194-86ab-993aa3bef543 |
| ECHA | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=34e12be2-ae49-4981-bd40-adf6628b33d6_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=34e12be2-ae49-4981-bd40-adf6628b33d6/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=d641dcc5-870c-4627-a2bb-396e17ed7c8d |
| ECHA | NOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=49f1a982-c9a5-498d-9274-55abe28a3a49.i6z; document=462ffc52-e87d-4224-9ea5-2ac898976f78_49f1a982-c9a5-498d-9274-55abe28a3a49.i6d; document_key=462ffc52-e87d-4224-9ea5-2ac898976f78/49f1a982-c9a5-498d-9274-55abe28a3a49; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=cff208ed-0e86-4416-9934-40d5926534d3 |