NOAEL Studies
Cosmetic Ingredient
ZINC ACETATE NOAEL Studies
CAS: 557-34-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
SCCS Opinion 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.1 | % | - | oral | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =0.43 | - | - | oral | - | NOAEL study | p.9 |
| SCCS Opinion | NOAEL | =1 | % | - | oral | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =6 | - | - | oral | 6 year | NOAEL study | p.15 |
| SCCS Opinion | NOAEL | =10 | - | - | - | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =16 | - | - | - | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =17 | - | - | oral | - | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =24 | - | - | - | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =37 | - | - | - | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =50 | - | - | - | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =53 | - | - | - | - | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =1657 | - | - | oral | - | NOAEL study | p.17 |
ECHA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =136 | mg/kg bw/day | Mouse | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17716/7/10/2?documentUUID=a81c8668-011c-4386-863a-f63c77d30a06; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15825519:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d85152cf70b2779125ea1c3d49520ead |
| ECHA | NOAEL | >=8 | mg/kg bw/day | Rat | injection | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c905e4b0a7c65d21b381; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17716/7/9/2?documentUUID=a81c8668-011c-4386-863a-f63c77d30a06; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15857517:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fc6d72bf89ba796dbea210c8281bdbf4 |
| ECHA | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab0de4b0a7c65d1b8a3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17716/7/9/2?documentUUID=a81c8668-011c-4386-863a-f63c77d30a06; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15855869:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_976cd0c72a6399d682574160a0131416 |
| ECHA | NOAEL | >=372 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab0de4b0a7c65d1b8a3a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17716/7/9/2?documentUUID=a81c8668-011c-4386-863a-f63c77d30a06; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15862060:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a28eb206cbb024e68b24a742dd382e94 |
ToxValDB ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.1 | mg/mL | Mouse | oral | short-term; 2 weeks | short-term | LONG_REF=- | J. Infect.50(5): 417-424 Tran,C.D., M.A.F. Campbell, Y. Kolev, S. Chamberlain, H.Q. Huynh, and R.N. Butler Short-Term Zinc Supplementation Attenuates Helicobacter felis-Induced Gastritis in the Mouse 2005; TITLE=Short-Term Zinc Supplementation Attenuates Helicobacter felis-Induced Gastritis in the Mouse; AUTHOR=Tran,C.D., M.A.F. Campbell, Y. Kolev, S. Chamberlain, H.Q. Huynh, and R.N. Butler; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100807; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Histology: Histological changes in stomach; STUDY_GROUP=ECOTOX:15613158:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=d87abb08ff3732f563637ab33b4809a5 |
| ToxValDB ECOTOX | LOEL | =20 | % w/v | Mouse | dermal | short-term; 5 days | short-term | LONG_REF=Food Chem. Toxicol.29(1): 57-64 Lansdown,A.B.G. Interspecies Variations in Response to Topical Application of Selected Zinc Compounds 1991; TITLE=Interspecies Variations in Response to Topical Application of Selected Zinc Compounds; AUTHOR=Lansdown,A.B.G.; DOI=10.1016/0278-6915(91)90063-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=85721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608793:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9717510e56a08a01fa115b740ffbd785 |
| ToxValDB ECOTOX | LOEL | =5000 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=- | Toxicol. Lett.29(1): 1-4 Rana,S.V.S., R. Prakash, A. Kumar, and C.B. Sharma A Study of Glycogen in the Liver of Metal-fed Rats 1985; TITLE=A Study of Glycogen in the Liver of Metal-fed Rats; AUTHOR=Rana,S.V.S., R. Prakash, A. Kumar, and C.B. Sharma; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=73682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Glycogen, increase; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613368:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=ad76450946ad7ac0835d32d27dc9efa5 |
| ToxValDB ECOTOX | NOEL | =444 | ppm | Rat | oral | short-term; 11 days | short-term | LONG_REF=Toxicol. Appl. Pharmacol.48:229-235 Khera,K.S., and B.G. Shah Failure of Zinc Acetate to Reduce Ethylenethiourea-Induced Fetal Anomalies in Rats 1979; TITLE=Failure of Zinc Acetate to Reduce Ethylenethiourea-Induced Fetal Anomalies in Rats; AUTHOR=Khera,K.S., and B.G. Shah; DOI=10.1016/0041-008x(79)90028-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=67806; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Early resorbed embryos|Reproduction: Late resorbed embryos|Reproduction: Pregnant, Paris or Gravid|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15596308:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=18b729ac19fb9b27c61109665f7a5326 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =4.71 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635761:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4b9a5b2d4c4688b33573219c56e9598 |
Regulatory source 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0.1 | % | - | oral | - | - | p.16 |
| Regulatory source | - | 0.43 | - | - | oral | - | - | p.9 |
| Regulatory source | - | 1 | % | - | oral | - | - | p.16 |
| Regulatory source | - | 6 | - | - | oral | 6 year | - | p.15 |
| Regulatory source | - | 10 | - | - | - | - | - | p.16 |
| Regulatory source | - | 16 | - | - | - | - | - | p.16 |
| Regulatory source | - | 17 | - | - | oral | - | - | p.17 |
| Regulatory source | - | 24 | - | - | - | - | - | p.16 |
| Regulatory source | - | 37 | - | - | - | - | - | p.16 |
| Regulatory source | - | 50 | - | - | - | - | - | p.16 |
| Regulatory source | - | 53 | - | - | - | - | - | p.16 |
| Regulatory source | - | 1657 | - | - | oral | - | - | p.17 |
openFDA substances 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | FM5526K07A | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | H2ZEY72PME | UNII | - | - | - | chemical | - |