NOAEL Studies Cosmetic Ingredient

ZINC NOAEL Studies

CAS: 7440-66-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ATSDR_toxval_ATSDR_MRLs.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =0.83 mg/kg/day Human (F) oral subchronic; 10 weeks clinical ATSDR MRLs; row_hash=0bda407b494840f5; source_hash=ToxValhc_4924d7bdcc80bb8c3c91388ec2affbcc; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.83; raw_unit=mg/kg/day; method=capsule; effect=hematological; effect_category=hematology; file=toxval_ATSDR_MRLs.xlsx; long_ref=Yadrick MK, Kenney MA, Winterfelt EA. 1989. Iron, copper, and zinc status: Response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr 49:145-150; stored_source_record=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c49
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =50 mg/day Human - - study with volunteers ENDPOINTSTUDY_ID 695448; TOX_ID 6071 - OP_ID 2170 - EFSA FEEDAP - 2013 - Scientific Opinion on the safety and efficacy of methionine-zinc, technically pure as amino acid for ruminants, and as compound of trace element for all species - doi:10.2903/j.efsa.2013.3038
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =53 mg/day Human - 90 days study with volunteers ENDPOINTSTUDY_ID 699391; TOX_ID 10632 - OP_ID 2969 - EFSA FEEDAP - 2017 - Safety and efficacy of zinc chelate of methionine sulfate for all animal species - doi:10.2903/j.efsa.2017.4859
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =40 mg/day Human oral: feed 98 days study with volunteers ENDPOINTSTUDY_ID 699393; TOX_ID 10634 - OP_ID 2969 - EFSA FEEDAP - 2017 - Safety and efficacy of zinc chelate of methionine sulfate for all animal species - doi:10.2903/j.efsa.2017.4859
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =50 mg/day Human - - study with volunteers ENDPOINTSTUDY_ID 695448; TOX_ID 6071 - OP_ID 2170 - EFSA FEEDAP - 2013 - Scientific Opinion on the safety and efficacy of methionine-zinc, technically pure as amino acid for ruminants, and as compound of trace element for all species - doi:10.2903/j.efsa.2013.3038
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =53 mg/day Human - 90 days study with volunteers ENDPOINTSTUDY_ID 699391; TOX_ID 10632 - OP_ID 2969 - EFSA FEEDAP - 2017 - Safety and efficacy of zinc chelate of methionine sulfate for all animal species - doi:10.2903/j.efsa.2017.4859
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =40 mg/day Human oral: feed 98 days study with volunteers ENDPOINTSTUDY_ID 699393; TOX_ID 10634 - OP_ID 2969 - EFSA FEEDAP - 2017 - Safety and efficacy of zinc chelate of methionine sulfate for all animal species - doi:10.2903/j.efsa.2017.4859
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA_IRIS_iris_rfd_systems.csv LOAEL =0.91 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=fb5852cb0471e464; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL : 0.91 mg/kg-day; system=Immune, Hematologic; basis=Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers; point_of_departure=LOAEL : 0.91 mg/kg-day; composite_uf=3; confidence=Medium/High; dtxsid=DTXSID7035012; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=426; rfd_last_updated=08/03/2005; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0426_summary.pdf
EPA_IRIS_iris_rfd_systems.csv RfD =0.3 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=3798869b515fa27b; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-1; system=Immune, Hematologic; basis=Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers; point_of_departure=LOAEL : 0.91 mg/kg-day; composite_uf=3; confidence=Medium/High; dtxsid=DTXSID7035012; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=426; rfd_last_updated=08/03/2005; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0426_summary.pdf
INCHEM_WHO_ehc_ehc_ehc221 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_ehc_ehc_ehc221 NOEL =2.3 mg/m3 Guinea pig; Pig - 5 days Toxicology study document_id=ehc_ehc_ehc221; title=Zinc (EHC 221, 2001); path=mirror/documents/ehc/ehc/ehc221.htm; row_hash=96d070a12b623292; raw_unit=mg/m 3; context=NOEL, 2.3 mg/m 3 Conner et al. (1988) Guinea-pigs (male Hartley, 5–8 per group) 0, 2.7or 7 mg/m 3 , 3 h/day for 5 days zinc oxide (median diameter 0.05 um) oedema, decrease in total lung capacity and diffusing capacity for CO at 7 mg/m 3 , oedema; no effects observed at 2.7 m
INCHEM_WHO_ehc_ehc_ehc221 NOEL <0.1 mg/g Mouse; Dog oral 14 months Toxicology study document_id=ehc_ehc_ehc221; title=Zinc (EHC 221, 2001); path=mirror/documents/ehc/ehc/ehc221.htm; row_hash=9a9a50b404ed9b00; raw_unit=ug/g; unit_normalization=converted from micrograms; context=NOEL, <100 ug/g Hagan et al. (1953) Mice 0.5 g/litre in drinking-water for 14 months zinc sulfate pancreatic hypertrophy, pituitary gland hypertrophy Aughey et al. (1977) Dogs 200 mg/kg body weight per day in diet reduced to 50 mg/kg body weight/day by week 35 zinc sulfate e
INCHEM_WHO_ehc_ehc_ehc221 NOEL =1500 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc221; title=Zinc (EHC 221, 2001); path=mirror/documents/ehc/ehc/ehc221.htm; row_hash=ddcaf2f26f68b220; raw_unit=mg/kg; context=NOEL, 1500 mg/kg Aulerich et al.
INCHEM_WHO_ehc_ehc_ehc221 NOEL =100 mg/kg bw Rat - - Toxicology study document_id=ehc_ehc_ehc221; title=Zinc (EHC 221, 2001); path=mirror/documents/ehc/ehc/ehc221.htm; row_hash=f65c04976ac98d0f; raw_unit=mg/kg; context=La dose sans effet observable (NOEL)- en prenant en compte l'effet sur la croissance et l'anémie imputables à la présence de sulfate de zinc dans l'alimentation- a été trouvée inférieure à 100 mg/kg chez le rat.
ToxValDB_ATSDR_MRLs 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ATSDR_MRLs MRL =0.3 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=hematological; STUDY_GROUP=ATSDR MRLs_dup_-_15447319_15447320:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1cd9138782b907a274f0a68241c5d0ef
ToxValDB_ATSDR_MRLs NOAEL =0.83 mg/kg bw/day Human oral subchronic; 10 weeks clinical LONG_REF=Yadrick MK, Kenney MA, Winterfelt EA. 1989. Iron, copper, and zinc status: Response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr 49:145-150; TITLE=Iron, copper, and zinc status: Response to supplementation with zinc or zinc and iron in adult females; AUTHOR=Yadrick MK; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f518e4b063812d585c49; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp60.pdf; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ATSDR MRLs:15447906:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4924d7bdcc80bb8c3c91388ec2affbcc
ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEC =0.55 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1803/7/6/3?documentUUID=93089a17-9c2c-4eaf-8903-70c9beb87b12; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15827225:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38e2d2c421cce320e6d145c6d3dbf989
ToxValDB_ECHA_IUCLID LOAEC =4.45 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1803/7/6/3?documentUUID=93089a17-9c2c-4eaf-8903-70c9beb87b12; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827979_15827980:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f221d683944679a8cd2e58636ebd7391
ToxValDB_ECHA_IUCLID LOAEL =53.8 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c886e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10228/7/6/2?documentUUID=819bf807-93be-4ebf-8cda-44ec703048cc; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830261_15832582_15834052_15834762_15838612_15838613_15843235_15843818_15843819_15844699:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03434560c6d26d85a132f28829fdd1f8
ToxValDB_ECHA_IUCLID NOAEC =1.48 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1803/7/6/3?documentUUID=93089a17-9c2c-4eaf-8903-70c9beb87b12; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827979_15827980:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03d25711e9495c8222aa15abb2647b42
ToxValDB_ECHA_IUCLID NOAEC =1.96 mg/m3 Rat inhalation short-term; 10 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1803/7/6/3?documentUUID=93089a17-9c2c-4eaf-8903-70c9beb87b12; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15828015:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a29c6de7209e6ed6d2a63c9010c8ac4
ToxValDB_ECHA_IUCLID NOAEC =0.47 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1803/7/6/3?documentUUID=93089a17-9c2c-4eaf-8903-70c9beb87b12; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15829447:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4e367a1f6239fdd36cfcc8886976719
ToxValDB_ECHA_IUCLID NOAEL =31.52 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf23e4b0a7c65d1ccaa8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25097/7/6/2?documentUUID=02025d7c-40e7-4687-8d39-a8c7c2a76ca0; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830261_15832582_15834052_15834762_15838612_15838613_15843235_15843818_15843819_15844699:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_07605fd27bd01c06b49af4c52fa105e0
ToxValDB_ECOTOX 22 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =350 ppm Rat oral short-term; 28 days short-term LONG_REF=J. Nutr. Biochem.6:48-54 Reeves,P.G. Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein 1995; TITLE=Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein; AUTHOR=Reeves,P.G.; DOI=10.1016/0955-2863(94)00008-A; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86643; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594185_15597480:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=af164971c14f3baba38dc00aa5e59c2a
ToxValDB_ECOTOX LOEL =3 mg/kg bw/day Rat injection short-term; 28 days short-term LONG_REF=Life Sci.78(7): 746-752 Baltaci,A.K., R. Mogulkoc, and A. Ozturk Testosterone and Zinc Supplementation in Castrated Rats: Effects on Plasma Leptin Levels and Relation with LH, FSH and Testosterone 2006; TITLE=Testosterone and Zinc Supplementation in Castrated Rats: Effects on Plasma Leptin Levels and Relation with LH, FSH and Testosterone; AUTHOR=Baltaci,A.K., R. Mogulkoc, and A. Ozturk; DOI=10.1016/j.lfs.2005.05.098; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=90096; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Hormone(s): Follicle stimulating hormone|Hormone(s): Leptin|Hormone(s): Luteinizing hormone|Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595280_15599243:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b615048ec1d029d63b8e30b43fd63e74
ToxValDB_ECOTOX LOEL =900 ppm Rat oral short-term; 9 days short-term LONG_REF=J. Inorg. Biochem.11:57-66 Hall,A.C., B.W. Young, and I. Bremner Intestinal Metallothionein and the Mutual Antagonism Between Copper and Zinc in the Rat 1979; TITLE=Intestinal Metallothionein and the Mutual Antagonism Between Copper and Zinc in the Rat; AUTHOR=Hall,A.C., B.W. Young, and I. Bremner; DOI=10.1016/s0162-0134(00)80054-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=102659; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Physiology: Copper uptake; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596168_15596169:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2cc62238a7856325b2d600c2ae1bd6a0
ToxValDB_ECOTOX LOEL =0.4 % Rat oral short-term; 21 days short-term LONG_REF=Nutr. Rep. Int.5(1): 61-66 Chu,R.C., and D.H. Cox Zinc, Iron, Copper, Calcium, Cytochrome Oxidase, and Phospholipid in Rats of Lactating Mothers Fed Excess Zinc 1972; TITLE=Zinc, Iron, Copper, Calcium, Cytochrome Oxidase, and Phospholipid in Rats of Lactating Mothers Fed Excess Zinc; AUTHOR=Chu,R.C., and D.H. Cox; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=89210; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Calcium content|Biochemistry: Copper (Cu) content|Biochemistry: Iron content|Biochemistry: Phosphatide phosphorus|Enzyme(s): Cytochrome C-oxidase|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596309_15601378:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a46e17c77a760e41ce8e01adeea12e6
ToxValDB_ECOTOX LOEL =150 ppm Rat oral short-term; 18 days short-term LONG_REF=Nutr. Rep. Int.13(1): 33-36 Kumar,S. Effect of Zinc Supplementation on Rats During Pregnancy 1976; TITLE=Effect of Zinc Supplementation on Rats During Pregnancy; AUTHOR=Kumar,S.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86639; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15597407:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=717b217a11d1b37f17473c003ccc3507
ToxValDB_ECOTOX LOEL =28.8 mg/kg bw/day Rat oral subchronic; 56 days subchronic LONG_REF=Chem.-Biol. Interact.29(3): 369-372 Bonner,F.W., L.J. King, and D.V. Parke Cadmium-Induced Reduction of Bone Alkaline Phosphatase and Its Prevention by Zinc 1980; TITLE=Cadmium-Induced Reduction of Bone Alkaline Phosphatase and Its Prevention by Zinc; AUTHOR=Bonner,F.W., L.J. King, and D.V. Parke; DOI=10.1016/0009-2797(80)90155-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=60337; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Cadmium content|Enzyme(s): Alkaline phosphatase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15601953:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b40577996116b4c0b7c08ac3504b7eb
ToxValDB_ECOTOX LOEL =0.5 % Rat oral short-term; 28 days short-term LONG_REF=J. Hypertens.22(3): 543-550 Yanagisawa,H., M. Sato, M. Nodera, and O. Wada Excessive Zinc Intake Elevates Systemic Blood Pressure Levels in Normotensive Rats - Potential Role of Superoxide-Induced Oxidative Stress 2004; TITLE=Excessive Zinc Intake Elevates Systemic Blood Pressure Levels in Normotensive Rats - Potential Role of Superoxide-Induced Oxidative Stress; AUTHOR=Yanagisawa,H., M. Sato, M. Nodera, and O. Wada; DOI=10.1097/00004872-200403000-00017; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101270; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15605594:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=27829796b145242fb63701979005114b
ToxValDB_ECOTOX LOEL =11.7 ppm Rat multiple subchronic; 49 days subchronic LONG_REF=Nutr. Res.9:161-171 Hunt,J.R., P.E. Johnson, and P.B. Swan Effect of Dietary Zinc on 65-Zn Absorption and Turnover in Rats 1989; TITLE=Effect of Dietary Zinc on 65-Zn Absorption and Turnover in Rats; AUTHOR=Hunt,J.R., P.E. Johnson, and P.B. Swan; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=79315; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15610679:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ea1c1fe852229efd511148f0d361bc8c
ToxValDB_ECOTOX LOEL =5000 mg/kg bw/day Mouse oral short-term; 14 days short-term LONG_REF=Toxicol. Lett.161(2): 115-123 Wang,B., W.Y. Feng, T.C. Wang, G. Jia, M. Wang, J.W. Shi, F. Zhang, Y.L. Zhao, and Z.F. Chai Acute Toxicity of Nano- and Micro-Scale Zinc Powder in Healthy Adult Mice 2006; TITLE=Acute Toxicity of Nano- and Micro-Scale Zinc Powder in Healthy Adult Mice; AUTHOR=Wang,B., W.Y. Feng, T.C. Wang, G. Jia, M. Wang, J.W. Shi, F. Zhang, Y.L. Zhao, and Z.F. Chai; DOI=10.1016/j.toxlet.2005.08.007; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=97888; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Albumin|Biochemistry: Blood urea nitrogen|Biochemistry: Cholesteryl ester|Biochemistry: Creatinine|Biochemistry: Hematocrit (anemia)|Biochemistry: Hemoglobin|Biochemistry: Protein, total|Cell(s): Diameter|Cell(s): Thrombocytes|Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Alkaline phosphatase|Enzyme(s): alpha-Hydroxybutyrate dehydrogenase|Enzyme(s): Aspartate aminotransferase|Enzyme(s): Lactate dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|hematology|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ECOTOX:15611772:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=4f25a66399c73d14ad17cf9515926c7a
ToxValDB_ECOTOX LOEL =48 mg/kg bw/day Rat oral subchronic; 42 days subchronic LONG_REF=Trace Elem. Med.6(2): 86-92 Sinha,A., R.S. Bedwal, and R.S. Mathur Biochemical Study of Female Reproductive Organs in Swiss Albino Rats on a High Zinc Diet 1989; TITLE=Biochemical Study of Female Reproductive Organs in Swiss Albino Rats on a High Zinc Diet; AUTHOR=Sinha,A., R.S. Bedwal, and R.S. Mathur; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81204; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Enzyme(s): Acid phosphatase|Enzyme(s): Alkaline phosphatase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity; STUDY_GROUP=ECOTOX:15611900:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=1afc0421cc182baf7c5b9d2a4d0aca02
ToxValDB_ECOTOX LOEL =500 mg/kg bw/day Rat oral short-term; 30 days short-term LONG_REF=Arh. Hig. Rada Toksikol.51(3): 279-286 Rana,S.V.S., and A. Kumar Metallothionein Induced by Cadmium or Zinc Inhibits Lipid Peroxidation in Rats Exposed to Dimethylnitrosamine 2000; TITLE=Metallothionein Induced by Cadmium or Zinc Inhibits Lipid Peroxidation in Rats Exposed to Dimethylnitrosamine; AUTHOR=Rana,S.V.S., and A. Kumar; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=84818; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15612404:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=b6290c1ca1899e2cd679841ae80d5972
ToxValDB_ECOTOX NOEL =23.4 mg/kg bw/day Rat oral chronic; 112 days chronic LONG_REF=Chem.-Biol. Interact.29(3): 369-372 Bonner,F.W., L.J. King, and D.V. Parke Cadmium-Induced Reduction of Bone Alkaline Phosphatase and Its Prevention by Zinc 1980; TITLE=Cadmium-Induced Reduction of Bone Alkaline Phosphatase and Its Prevention by Zinc; AUTHOR=Bonner,F.W., L.J. King, and D.V. Parke; DOI=10.1016/0009-2797(80)90155-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=60337; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594154_15596682:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=91aef64b9e3e91f4d346162715a29a68
ToxValDB_ECOTOX NOEL =33.6 mg/kg bw/day Rat oral subchronic; 35 days subchronic LONG_REF=J. Nutr. Biochem.6:48-54 Reeves,P.G. Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein 1995; TITLE=Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein; AUTHOR=Reeves,P.G.; DOI=10.1016/0955-2863(94)00008-A; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86643; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Copper (Cu) content|Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594186_15604677_15610816_15610825:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f778490e79b8af6ba73147774eae3bd1
ToxValDB_ECOTOX NOEL =1000 ppm Rat oral acute; 1 days acute LONG_REF=Diabetologia31(9): 703-707 Mooradian,A.D., D.C. Norman, and J.E. Morley The Effect of Zinc Status on the Immune Function of Diabetic Rats 1988; TITLE=The Effect of Zinc Status on the Immune Function of Diabetic Rats; AUTHOR=Mooradian,A.D., D.C. Norman, and J.E. Morley; DOI=10.1007/BF00278755; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86004; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15594843:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=710c468831aef493c992b89db1d3bd1b
ToxValDB_ECOTOX NOEL =100 ppm Rat oral short-term; 7 days short-term LONG_REF=J. Nutr. Biochem.6:48-54 Reeves,P.G. Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein 1995; TITLE=Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein; AUTHOR=Reeves,P.G.; DOI=10.1016/0955-2863(94)00008-A; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86643; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Copper (Cu) content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594187_15595119_15596344_15600005:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fc344fa255aca17fd453f529c55b15c3
ToxValDB_ECOTOX NOEL =200 ppm Mouse oral short-term; 14 days reproduction developmental LONG_REF=Behav. Brain Res.186(2): 230-238 Summers,B.L., C.M.A. Henry, A.M. Rofe, and P. Coyle Dietary Zinc Supplementation During Pregnancy Prevents Spatial and Object Recognition Memory Impairments Caused by Early Prenatal Ethanol Exposure 2008; TITLE=Dietary Zinc Supplementation During Pregnancy Prevents Spatial and Object Recognition Memory Impairments Caused by Early Prenatal Ethanol Exposure; AUTHOR=Summers,B.L., C.M.A. Henry, A.M. Rofe, and P. Coyle; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101711; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15595804:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f3d5b40ec23e76c4e9669cacbfcef9a3
ToxValDB_ECOTOX NOEL =450 ppm Rat oral short-term; 9 days short-term LONG_REF=J. Inorg. Biochem.11:57-66 Hall,A.C., B.W. Young, and I. Bremner Intestinal Metallothionein and the Mutual Antagonism Between Copper and Zinc in the Rat 1979; TITLE=Intestinal Metallothionein and the Mutual Antagonism Between Copper and Zinc in the Rat; AUTHOR=Hall,A.C., B.W. Young, and I. Bremner; DOI=10.1016/s0162-0134(00)80054-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=102659; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Physiology: Copper uptake; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596168_15596169:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=aa89e1445e68b819cce3fc344f3b8615
ToxValDB_ECOTOX NOEL =60 ppm Rat oral short-term; 28 days short-term LONG_REF=J. Musculoskelet. Neuronal Interact.4(4): 428-435 Ovesen,J., G. Danscher, J.S. Thomsen, L. Mosekilde, and B. Moller-Madsen Autometallographic Tracing of Zinc Ions in Growing Bone 2004; TITLE=Autometallographic Tracing of Zinc Ions in Growing Bone; AUTHOR=Ovesen,J., G. Danscher, J.S. Thomsen, L. Mosekilde, and B. Moller-Madsen; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100806; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Height|Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15596714:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4a2d346559f2d1067c874e056bb1a600
ToxValDB_ECOTOX NOEL =0.5 % Rat oral subchronic; 56 days subchronic LONG_REF=J. Hypertens.22(3): 543-550 Yanagisawa,H., M. Sato, M. Nodera, and O. Wada Excessive Zinc Intake Elevates Systemic Blood Pressure Levels in Normotensive Rats - Potential Role of Superoxide-Induced Oxidative Stress 2004; TITLE=Excessive Zinc Intake Elevates Systemic Blood Pressure Levels in Normotensive Rats - Potential Role of Superoxide-Induced Oxidative Stress; AUTHOR=Yanagisawa,H., M. Sato, M. Nodera, and O. Wada; DOI=10.1097/00004872-200403000-00017; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101270; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Genetics: nitric oxide synthase mRNA; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596846_15597209:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f815b1e398b9677611e2162878c22826
ToxValDB_ECOTOX NOEL =22.656 mg/kg bw/day Rat oral subchronic; 56 days subchronic LONG_REF=Folia Med.47(1): 42-46 Dimitrova,A.A., D.S. Strashimirov, A.L. Russeva, P.A. Andreeva-Gateva, E.T. Lakova, and K.N. Tzachev Effect of Zinc on the Activity of Cu/Zn Superoxide Dismutase and Lipid Profile in Wistar Rats 2005; TITLE=Effect of Zinc on the Activity of Cu/Zn Superoxide Dismutase and Lipid Profile in Wistar Rats; AUTHOR=Dimitrova,A.A., D.S. Strashimirov, A.L. Russeva, P.A. Andreeva-Gateva, E.T. Lakova, and K.N. Tzachev; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=102016; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Cholesterol|Biochemistry: High density lipoprotein cholesterol|Biochemistry: Triglycerides|Enzyme(s): Copper zinc superoxide dismutase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598153_15607264:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e52f145fd04cc58a8c79672b0a3b1559
ToxValDB_ECOTOX NOEL =0.0018 mmol Rat injection acute; 0.0417 days acute LONG_REF=J. Lab. Clin. Med.82(3): 399-405 Perry,H.M.,Jr., and M.W. Erlanger Elevated Circulating Renin Activity in Rats Following Doses of Cadmium Known to Induce Hypertension 1973; TITLE=Elevated Circulating Renin Activity in Rats Following Doses of Cadmium Known to Induce Hypertension; AUTHOR=Perry,H.M.,Jr., and M.W. Erlanger; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=87935; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1973; ORIGINAL_YEAR=1973; TOXICOLOGICAL_EFFECT=Enzyme(s): Renin; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX:15600731:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5926542caba178c00a70fded70f9892b
ToxValDB_ECOTOX NOEL =100 mg/kg bw/day Rat oral subchronic; 35 days subchronic LONG_REF=J. Nutr. Biochem.6:48-54 Reeves,P.G. Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein 1995; TITLE=Adaptation Responses in Rats to Long-Term Feeding of High-Zinc Diets: Emphasis on Intestinal Metallothionein; AUTHOR=Reeves,P.G.; DOI=10.1016/0955-2863(94)00008-A; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86643; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Copper (Cu) content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594186_15604677_15610816_15610825:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5856a3af4835a823784cb0fe492bba95
ToxValDB_Health_Canada 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Health_Canada LOAEL =60 mg/day Human oral subchronic; 10 weeks clinical LONG_REF=IOM, 2001 (adult data based on Yadrick et al., 1989; infants and children data based on Walravens and Hambidge, 1976); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=reduced iron and copper status; STUDY_GROUP=Health Canada:15637591:-:-adult; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3a1e042cb31461944321aca780fff91
ToxValDB_Health_Canada NOAEL =4.5 mg/day Human oral chronic; 6 months clinical LONG_REF=Walravens and Hambidge, 1976; AUTHOR=Walravens and Hambidge; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=increased growth of infant: length, weight, and head circumference; STUDY_GROUP=Health Canada:15637592:-:-infants and children; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_625d9357bf8d9ee95f9637e75aecb154
ToxValDB_IRIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_IRIS LOAEL =0.91 mg/kg bw/day Human oral - clinical LONG_REF=Yadrick, MK; Kenney, MA; Winterfeldt, EA. (1989) Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr 49:145-150. ; Fischer, PW; Giroux, A; L'Abbe, MR. (1984) Effect of zinc supplementation on copper status in adult man. Am J Clin Nutr 40:743-746. ; Davis, CD; Milne, DB; Nielsen, FH. (2000) Changes in dietary zinc and copper affect zinc?status indicators of postmenopausal women, notably, extracellular superoxide dismutase and amyloid precursor proteins. Am J Clin Nutr 71:781-788. ; Milne, DB; Davis, CD; Nielsen, FH. (2001) Low dietary zinc alters indices of copper function and status in postmenopausal women. Nutrition 17:701-708.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5ab3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=426; TOXICOLOGICAL_EFFECT=decreased erythrocyte cu, zn-superoxide dismutase (esod) activity in healthy adult male and female volunteers; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS:15645587:M/F:-adult; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_19b2ed8b54f28347eef25101ce2378e9
ToxValDB_WHO_JECFA_Tox_Studies 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_Tox_Studies NOAEL =220 mg/day Human oral - clinical LONG_REF=Brewer, R., Mihaldzie, N. & Dietz, A. (1967). The effect of oral zinc sulfate on the healing of decubitus ulcers in spinal cord injured patients, Proc. Annu. Clin. Spinal Cord Inj. Conf., 16, 70-72.; Carruthers, R. (1969). Oral zinc sulphate in leg ulcers, Lacet, 1, 1264.; Cohen, C. (1969). Oral zinc sulphate in leg ulcers, Lancet, 1, 1213.; Husain, S. (1969). Oral zinc sulphate in leg ulcers, Lancet, II, 1069-1073.; Serjeant, G., Galloway, R. & Gueri, M. (1970). Oral zinc sulphate in sickle-cell ulcers, Lancet, II, 891-893.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b04a7e4b0d99f5a88a79f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/4197; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=No significant adverse effects; STUDY_GROUP=WHO JECFA Tox Studies:15716195:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2ffe0be2d75b2ef3f4f839bed393cd11
ToxValDB_WHO_JECFA_Tox_Studies NOAEL =600 mg/day Human oral - clinical LONG_REF=Brewer, R., Mihaldzie, N. & Dietz, A. (1967). The effect of oral zinc sulfate on the healing of decubitus ulcers in spinal cord injured patients, Proc. Annu. Clin. Spinal Cord Inj. Conf., 16, 70-72.; Carruthers, R. (1969). Oral zinc sulphate in leg ulcers, Lacet, 1, 1264.; Cohen, C. (1969). Oral zinc sulphate in leg ulcers, Lancet, 1, 1213.; Husain, S. (1969). Oral zinc sulphate in leg ulcers, Lancet, II, 1069-1073.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b04a7e4b0d99f5a88a79f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/4197; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=No significant adverse effects; STUDY_GROUP=WHO JECFA Tox Studies:15716196:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b2cd8213db38a849a96092c06140cea4
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier J41CSQ7QDS UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"J41CSQ7QDS"}
openFDA substances FDA UNII substance identifier J41CSQ7QDS UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"J41CSQ7QDS"}
openFDA substances FDA UNII substance identifier J41CSQ7QDS UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"J41CSQ7QDS"}
openFDA substances FDA UNII substance identifier J41CSQ7QDS UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"J41CSQ7QDS"}