Good Cosmetic Ingredient NOAEL Data GHS Classified

ZINC

CAS Number
7440-66-6
Function
Antioxidant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

1 study endpoint found for ZINC. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
UL =0.71 mg/kg/day oral human chronic SCCS

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; enviro;aqua
Hazard Statements
Catches fire spontaneously if exposed to air In contact with water releases flammable gases which may ignite spontaneously Very toxic to aquatic life with long lasting effects
Short-term Exposure Effects
May cause mechanical irritation to the eyes and respiratory tract. Inhalation of the respirable fraction may cause metal fume fever. This may result in influenza-like symptoms. The effects may be delayed up to 48 hours.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged inhalation may cause effects on the lungs. This may result in reduced lung function .
Routes of Exposure
The substance can be absorbed into the body by inhalation.

Expert Verdict

ZINC is listed in the EU CosIng database with functions: Antioxidant It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted antioxidant needs-enrichment endocrine_disruptor

Frequently Asked Questions

Is ZINC safe in cosmetics?

ZINC is listed in the EU CosIng database with functions: Antioxidant It is permitted in the EU without specific restrictions. The EU classifies ZINC as "Permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is ZINC allowed in the EU?

ZINC EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does ZINC do in cosmetics?

ZINC functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 7440-66-6.

What is the NOAEL for ZINC?

The NOAEL (No Observed Adverse Effect Level) for ZINC is =0.71 mg/kg/day based on a chronic study via oral route in human. Source: SCCS.

Is ZINC classified as hazardous under GHS?

ZINC carries a GHS signal word of "DANGER". Hazard statements: Catches fire spontaneously if exposed to air In contact with water releases flammable gases which may ignite spontaneously Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check ZINC compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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