Proline
CAS 147-85-3
Proline (CAS 147-85-3) is a Phase 2 pharmaceutical compound with 2 bioactivity targets and 5 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | GI50 | 99265.71810344828 nM | 58 | - |
| - | AC50 | 30000 nM | 31 | - |
| - | Potency | 22648.239999999998 nM | 5 | - |
| - | IC50 | 19050.873333333333 nM | 2 | - |
| - | Ki | 86000 nM | 1 | - |
| Angiotensin-converting enzyme Enzyme |
Ki | 4.07 | - | Homo sapiens |
| Glutamate receptor ionotropic, NMDA 1 Ion channel |
IC50 | 4.76 | - | Rattus norvegicus |
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Foetal growth restriction | 15 | 64.616 | 10070531 |
| Compartment syndrome | 10 | 49.24 | 10010121 |
| Device related sepsis | 10 | 46.307 | 10069802 |
| Vasoplegia syndrome | 9 | 46.3 | 10067080 |
| Infantile apnoea | 8 | 44.253 | 10077321 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| Proline | 8737 | SU | MTHSPL |
| PROLINE | 8737 | SU | MTHSPL |
| proline | 8737 | SU | MTHSPL |
| proline | 8737 | IN | RXNORM |
| L-proline | 8737 | SY | RXNORM |
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Proline used for in pharmaceutical contexts?
Proline (CAS 147-85-3) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Proline?
Proline has 5 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Foetal growth restriction, Compartment syndrome, Device related sepsis, Vasoplegia syndrome, Infantile apnoea. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Proline also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for L-Proline with EU status "permitted".
What clinical phase is Proline in?
Proline is rendered with ChEMBL max phase 2.
What bioactivity targets are documented for Proline?
Proline has 7 bioactivity rows in this page query. Rendered target entries include Angiotensin-converting enzyme, Glutamate receptor ionotropic, NMDA 1.