Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for L-Proline. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2772.9 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1693 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
Dermal Penetration Profile
Skin absorption and penetration characteristics of L-Proline, relevant to systemic exposure and MoS calculations.
Source: Cosmetic Science
Expert Verdict
Structural collagen amino acid with excellent safety profile and no regulatory restrictions in EU or US at cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is L-Proline safe in cosmetics?
Structural collagen amino acid with excellent safety profile and no regulatory restrictions in EU or US at cosmetic use levels. The EU classifies L-Proline as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.
Is L-Proline allowed in the EU?
L-Proline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Proline do in cosmetics?
L-Proline functions as: Dominant residue in collagen Gly-X-Y repeat. Major structural component of collagen; among the most common amino acids in cosmetic formulations.. It is classified as a Active Ingredient in our database. CAS number: 147-85-3.
What is the Margin of Safety for L-Proline?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Proline?
The NOAEL (No Observed Adverse Effect Level) for L-Proline is 50 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check L-Proline compliance across multiple jurisdictions:
Related Ingredients
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