L-Citrulline
CAS 372-75-8
L-Citrulline (CAS 372-75-8) is a Phase 3 pharmaceutical compound with 3 bioactivity targets and 3 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | AC50 | 30000 nM | 31 | - |
| - | IC50 | 19976.309999999998 nM | 1 | - |
| - | Kd | 68000 nM | 1 | - |
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Hyperammonaemic crisis | 16 | 155.593 | 10073509 |
| Hyperammonaemia | 12 | 56.735 | 10020575 |
| Ammonia increased | 11 | 54.65 | 10001946 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
IUPHAR Ligand-Target Data
Curated ligand-target interaction rows with action, affinity, and literature identifiers.
| Target | Action | Affinity | PubMed |
|---|---|---|---|
| GPRC6 GPRC6A |
Full agonist | 3.6 pEC50 | 15576628 |
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| CITRULLINE | 2567 | SU | MTHSPL |
| citrulline | 2567 | IN | RXNORM |
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is L-Citrulline used for in pharmaceutical contexts?
L-Citrulline (CAS 372-75-8) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for L-Citrulline?
L-Citrulline has 3 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Hyperammonaemic crisis, Hyperammonaemia, Ammonia increased. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is L-Citrulline also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for CITRULLINE with EU status "permitted".
What clinical phase is L-Citrulline in?
L-Citrulline is rendered with ChEMBL max phase 3.