Is CITRULLINE safe in cosmetics?
CITRULLINE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
CITRULLINE
Also known as: L-Ornithine, N5-(aminocarbonyl)-, N5-(Aminocarbonyl)-L-ornithine, Ornithine, N5-carbamoyl-, L-, α-Amino-δ-ureidovaleric acid, δ-Ureidonorvaline (+6 more)
CITRULLINE (CAS 372-75-8) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 372-75-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-amino-5-(carbamoylamino)pentanoic acid
InChIKey
RHGKLRLOHDJJDR-BYPYZUCNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
amino_acid
{"cas_number": "372-75-8", "ingredient_class": "amino_acid", "source_origin": "fermentation", "molecular_weight_range_Da": "175", "amino_acid_composition_key": "pure_citrulline", "isoelectric_point": "5.9", "charge_at_pH_5_5": "zwitterionic", "water_solubility": "soluble", "oil_solubility": "insoluble", "film_forming_ability": "poor", "moisture_binding_capacity": "good", "NMF_component": "no", "sk…
anti_aging
{"anti_aging_claim": "barrier-repair, antioxidant-protection", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "5-10", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Int J C…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for CITRULLINE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
L-Ornithine, N5-(aminocarbonyl)-
N5-(Aminocarbonyl)-L-ornithine
Ornithine, N5-carbamoyl-, L-
α-Amino-δ-ureidovaleric acid
δ-Ureidonorvaline
L-(+)-Citrulline
L-Citrulline
Nδ-Carbamylornithine
N5-Carbamoyl-L-ornithine
Cit
NSC 27425
Chemical Function
Softener and conditioner
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
L-CITRULLINE
ChEMBL ID
CHEMBL444814
Max Phase
3
Adverse Event Associations
3
Frequently Asked Questions
Is CITRULLINE allowed in the EU?
CITRULLINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CITRULLINE do in cosmetics?
CITRULLINE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 372-75-8.
Is CITRULLINE used outside cosmetics?
CITRULLINE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CITRULLINE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
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Flavouring, Fragrance
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