Is CITRULLINE safe in cosmetics?
CITRULLINE has a safety rating of "GOOD" in our database. EU status: permitted.
GOOD
Cosmetic Ingredient
CITRULLINE
Also known as: L-Ornithine, N5-(aminocarbonyl)-, N5-(Aminocarbonyl)-L-ornithine, Ornithine, N5-carbamoyl-, L-, α-Amino-δ-ureidovaleric acid, δ-Ureidonorvaline (+6 more)
CITRULLINE (CAS 372-75-8) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Skin Conditioning
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(2S)-2-amino-5-(carbamoylamino)pentanoic acid
InChIKey
RHGKLRLOHDJJDR-BYPYZUCNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Editorial summary
Preliminary editorial summary for CITRULLINE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
L-Ornithine, N5-(aminocarbonyl)-
N5-(Aminocarbonyl)-L-ornithine
Ornithine, N5-carbamoyl-, L-
α-Amino-δ-ureidovaleric acid
δ-Ureidonorvaline
L-(+)-Citrulline
L-Citrulline
Nδ-Carbamylornithine
N5-Carbamoyl-L-ornithine
Cit
NSC 27425
Chemical Function
Softener and conditioner
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
L-CITRULLINE
ChEMBL ID
CHEMBL444814
Max Phase
3
Adverse Event Associations
3
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
L-Citrulline
Food Category
sports_nutrition
Frequently Asked Questions
Is CITRULLINE allowed in the EU?
CITRULLINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CITRULLINE do in cosmetics?
CITRULLINE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 372-75-8.
Is CITRULLINE used outside cosmetics?
CITRULLINE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CITRULLINE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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GOOD
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
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Similar safety
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(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
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Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
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Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
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Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
GOOD
Similar safety
Antioxidant
CITRUS AURANTIFOLIA FLOWER EXTRACT
MODERATE
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Flavouring, Fragrance
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