Genistein
CAS 446-72-0
Genistein (CAS 446-72-0) is a Phase 2 pharmaceutical compound with 11 bioactivity targets and 7 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | IC50 | 28063.807942386833 nM | 239 | - |
| - | Potency | 18807.401734104045 nM | 113 | - |
| - | GI50 | 56884.346836734694 nM | 98 | - |
| - | EC50 | 21480.20388888889 nM | 36 | - |
| - | Ki | 18497.199739130436 nM | 23 | - |
| - | MIC | 136.7 ug.mL-1 | 20 | - |
| - | IC50 | 14.096875 ug.mL-1 | 15 | - |
| - | MIC | 50000 nM | 7 | - |
| - | Kd | 26442.68 nM | 5 | - |
| - | AC50 | 7058.03 nM | 4 | - |
| - | EC50 | 13.9 ug.mL-1 | 1 | - |
IUPHAR Ligand-Target Data
Curated ligand-target interaction rows with action, affinity, and literature identifiers.
| Target | Action | Affinity | PubMed |
|---|---|---|---|
| CFTR CFTR |
Potentiation | - | - |
| Estrogen receptor-β ESR2 |
Agonist | 8.2 pKi | 9048584 |
| Estrogen-related receptor-α ESRRA |
Agonist | - | 14638870 |
| Estrogen-related receptor-β ESRRB |
Agonist | - | 14638870 |
| Estrogen-related receptor-γ ESRRG |
Agonist | - | 14638870 |
| TAS2R14 TAS2R14 |
Agonist | 4.190000057220459 pEC50 | 30009876 |
| TAS2R39 TAS2R39 |
Agonist | 4.309999942779541 pEC50 | 21942422 |
| TRPC5 TRPC5 |
Activator | - | 20233211 |
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| GENISTEIN | 25696 | SU | MTHSPL |
| genistein | 25696 | IN | RXNORM |
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Genistein used for in pharmaceutical contexts?
Genistein (CAS 446-72-0) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Genistein?
Genistein has 7 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Death, Dizziness, Heart rate irregular, Incorrect dose administered. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Genistein also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Soy Isoflavones with EU status "permitted".
What clinical phase is Genistein in?
Genistein is rendered with ChEMBL max phase 2.