Also known as: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, Isoflavone, 4',5,7-trihydroxy-, 4',5,7-Trihydroxyisoflavone, genistein (+15 more)
INCI: SOY ISOFLAVONES
Soy Isoflavones (CAS 446-72-0) is a cosmetic active ingredient functioning as 5-alpha-reductase inhibitor; phytoestrogen blend; ER modulator;. NOAEL 4 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 4 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
View industrial chemical safety profile for CAS 446-72-0 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Soy Isoflavones.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Soy Isoflavones. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =4 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =4 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =4 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =4 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =5 mg/kg bw/d | - | human | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg bw/d | - | human | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg bw/d | - | human | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | reproductive toxicity | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
Pre-calculated NOAEL → SED → MoS audit trail for Soy Isoflavones across SCCS product categories, with measured dermal absorption where available.
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Source list: II (former)
agonist (ERα, ERβ, PPARγ); antagonist (AR)
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| UK | restricted | - | - |
| ASEAN | restricted | Updated concentration limits per 2025–2026 ACD revision | Cosmetic products as active |
| MY | restricted (updated limits) | Updated per ACD 2025 revision — lower than previous | All cosmetic products using as active |
Expert safety assessment and concern-level summary for Soy Isoflavones.
Public NOAEL study rows linked to Soy Isoflavones by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg
Same-CAS public records found in pharmaceutical and food safety data.
Same-CAS rows from the pharmaceutical spoke database.
Same-CAS food additive or FDA GRAS records from the core public database.
Soy Isoflavones has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Soy Isoflavones EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Soy Isoflavones functions as: 5-alpha-reductase inhibitor; phytoestrogen blend; ER modulator; anti-androgenic; antioxidant; hair-growth active. It is classified as a Active Ingredient in our database. CAS number: 446-72-0.
The NOAEL (No Observed Adverse Effect Level) for Soy Isoflavones is =4 mg/kg bw/day based on a NOAEL study study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Soy Isoflavones also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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