Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Soy Isoflavones. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.3 mg/kg/day | oral | rat (Sprague-Dawley) | reproductive | SCCS |
| NOAEL | >50 mg/kg/day | oral | rat | subchronic | SCCS |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
e and justified than the data from oral studies. The SCCS considers that the calculation of margin of safety (MoS) for daidzein based on the data from subcutaneous route would provide a more reliable indicator of SCCS/1641/22 Final version Corrigendum October 2022 Opinion on genistein and daidzein
Expert Verdict
Soy isoflavones (genistein, daidzein, equol) inhibit 5ฮฑ-reductase and modulate estrogen receptors, relevant to postmenopausal hair loss; evidence is primarily in vitro and observational. Cosmetic classification is maintained at standard concentrations, but claims referencing hormonal or DHT mechanisms require careful framing under EU cosmetics law. Safety profile is good at cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is Soy Isoflavones safe in cosmetics?
Soy isoflavones (genistein, daidzein, equol) inhibit 5ฮฑ-reductase and modulate estrogen receptors, relevant to postmenopausal hair loss; evidence is primarily in vitro and observational. Cosmetic classification is maintained at standard concentrations, but claims referencing hormonal or DHT mechanisms require careful framing under EU cosmetics law. Safety profile is good at cosmetic use levels. The EU classifies Soy Isoflavones as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is Soy Isoflavones allowed in the EU?
Soy Isoflavones EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Soy Isoflavones do in cosmetics?
Soy Isoflavones functions as: 5-alpha-reductase inhibitor; phytoestrogen blend; ER modulator; anti-androgenic; antioxidant; hair-growth active. It is classified as a Active Ingredient in our database. CAS number: 446-72-0.
What is the Margin of Safety for Soy Isoflavones?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Soy Isoflavones?
The NOAEL (No Observed Adverse Effect Level) for Soy Isoflavones is =0.3 mg/kg/day based on a reproductive study via oral route in rat (Sprague-Dawley). A total of 2 study endpoints are available. Source: SCCS.
Compliance Tools
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Related Ingredients
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