Cosmetic cross-reference

Serotonin

CAS 50-67-9

Serotonin (CAS 50-67-9) is a Phase 3 pharmaceutical compound with 9 bioactivity targets and 1 adverse event association.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral

Adverse signals

SOURCE IUPHAR/BPS

PubMed IDs

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Serotonin

CAS Number

50-67-9

UNII

333DO1RDJY

InChIKey

QZAYGJVTTNCVMB-UHFFFAOYSA-N

ChEMBL ID

CHEMBL39

Molecule Type

Small molecule

Source Match

EMBL-EBI ChEMBL (INCHIKEY)

natural product

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Clinical Development Phase

Highest clinical development phase rendered from the matched compound identifier rows.

Phase 3

Late-stage clinical development phase from the compound identifier source.

ChEMBL CHEMBL39 | Small molecule

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE EMBL-EBI ChEMBL 9 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
-	Ki	1310.289581042654 nM	208	-
-	EC50	2551.6228772272725 nM	186	-
-	IC50	2902.0074725274726 nM	90	-
-	Potency	16462.146666666664 nM	19	-
-	MIC	56.4 ug.mL-1	5	-
-	AC50	12181.266 nM	4	-
-	Kd	4846.99 nM	2	-
-	EC50	0.0083 ug.mL-1	1	-
-	MIC	1134900 nM	1	-

SOURCE IUPHAR/BPS 37 interactions

IUPHAR Ligand-Target Data

Curated ligand-target interaction rows with action, affinity, and literature identifiers.

Target	Action	Affinity	PubMed
5-HT 1A receptor HTR1A	Full agonist	9.1 pKi	1386736\|9760039\|10431754\|9550290\|9205951\|15628665
5-HT 1B receptor HTR1B	Full agonist	7.4 pKi	10431754\|1565658\|9208142\|9776361\|11040052\|8957260
5-HT 1B receptor HTR1B	Full agonist	7.5 pKd	1565658\|8863519
5-HT 1B receptor Htr1b	Full agonist	8.1 pKi	1557407
5-HT 1D receptor HTR1D	Full agonist	8.0 pKi	10431754\|1565658\|9208142\|9776361\|8957260\|8967979\|1652050
5-HT 1F receptor HTR1F	Full agonist	8.0 pKd	8380639
5-HT 1F receptor HTR1F	Full agonist	7.7 pKi	15900510\|8380639\|9225282
5-HT 1F receptor Htr1f	Full agonist	7.2 pIC50	8384716
5-HT 2A receptor HTR2A	Full agonist	8.9 pKd	8534270
5-HT 2A receptor HTR2A	Full agonist	6.0 pKi	15322733\|8534270\|12954071\|2233697\|8114677\|8663249
5-HT 2A receptor Htr2a	Full agonist	6.0 pKi	11040033\|11104741\|9655845
5-HT 2B receptor HTR2B	Full agonist	7.9 pKi	15322733\|12954071\|11104741\|8078486\|15466450
5-HT 2B receptor Htr2b	Full agonist	8.0 pKi	8450835
5-HT 2C receptor HTR2C	Full agonist	6.8 pKi	15322733\|12954071\|10217294\|10611640\|14709324
5-HT 2C receptor Htr2c	Full agonist	6.7 pKi	11104741\|9282936
5-HT 3 A HTR3A	Agonist	5.5 pEC50	9950429\|8848005\|7565620\|10521471\|9463477\|16081679\|10825381
5-HT 3 A HTR3A	Agonist	6.5 pKi	9463477\|11489465\|8818349\|11104834
5-HT 3 AB HTR3A\|HTR3B	Agonist	6.0 pKi	11489465
5-HT 3 AB HTR3A\|HTR3B	Agonist	4.800000190734863 pEC50	9950429\|10521471\|16081679\|10825381
5-HT 4 receptor Htr4	Full agonist	6.7 pKi	7796807\|8813606\|9225293
5-HT 4 receptor Htr4	Full agonist	7.2 pKi	8946946
5-HT 4 receptor Htr4	Full agonist	7.699999809265137 pKd	8813606
5-HT 4 receptor HTR4	Full agonist	5.9 pKi	15466450\|9349523\|9603189\|9351641\|10646498\|11218067\|10683202\|11030734\|10821780\|15351779
5-HT 4 receptor HTR4	Full agonist	8.399999618530273 pKd	10646498
5-HT 5A receptor Htr5a	Full agonist	6.6 pKi	7682702
5-HT 5A receptor HTR5A	Full agonist	6.7 pKi	7988681\|11343685
5-HT 5A receptor Htr5a	Full agonist	6.0 pKi	8450829\|11343685\|8549774
5-HT 6 receptor Htr6	Full agonist	7.900000095367432 pKd	9225298
5-HT 6 receptor HTR6	Full agonist	6.8 pKi	8522988\|9730917\|9284367
5-HT 6 receptor Htr6	Full agonist	6.6 pKi	7680751\|9225298\|9798944\|9730917
5-HT 7 receptor Htr7	Full agonist	8.3 pKi	8394987
5-HT 7 receptor HTR7	Full agonist	8.1 pKi	12527336\|11414657\|9298538\|8226867\|9720804
5-HT 7 receptor Htr7	Full agonist	8.699999809265137 pKi	8394362\|8397408
5-ht 1e receptor HTR1E	Full agonist	8.0 pKi	1608964\|8380639\|14744596\|15110837
D 1 receptor DRD1	Partial agonist	5.0 pKi	1826762
D 5 receptor DRD5	Full agonist	5.5 pKi	1826762
Proton-coupled Amino acid Transporter 1 SLC36A1	Inhibition	2.2 pKi	16126914

SOURCE PharmGKB 2 phenotype rows

Pharmacogenomics

Drug-gene phenotype annotations and evidence levels from PharmGKB-mapped rows.

ERICH3 (PA142672422) rs696692

Allele T is associated with decreased concentrations of serotonin in people with Depressive Disorder as compared to allele C.

Evidence: -; PMID 26903268

TSPAN5 (PA134864098) rs11947402

Allele G is associated with decreased concentrations of serotonin in people with Depressive Disorder as compared to allele A.

Evidence: -; PMID 26903268

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Serotonin used for in pharmaceutical contexts?

Serotonin (CAS 50-67-9) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Serotonin?

Serotonin has 1 DrugCentral/FAERS adverse event association. Rendered reaction terms include Complication of device insertion. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Serotonin also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for Serotonin with EU status "prohibited".

What clinical phase is Serotonin in?

Serotonin is rendered with ChEMBL max phase 3.