Serotonin

INCI: SEROTONIN

CAS Number
50-67-9
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not specifically listed as a prohibited cosmetic ingredient by FDA; however, its pharmacological activity as a neurotransmitter creates a potential drug-cosmetic boundary issue.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potent vasoactive neurotransmitter with potential for vasodilation, flushing, and edema at high dermal doses; significant drug-cosmetic boundary risk; no SCCS or CIR safety opinion available; requires robust safety assessment.

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Concern Level: High

Frequently Asked Questions

Is Serotonin safe in cosmetics?

Potent vasoactive neurotransmitter with potential for vasodilation, flushing, and edema at high dermal doses; significant drug-cosmetic boundary risk; no SCCS or CIR safety opinion available; requires robust safety assessment. The EU classifies Serotonin as "prohibited". Safety rating: MODERATE.

Is Serotonin allowed in the EU?

Serotonin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Serotonin do in cosmetics?

Serotonin functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 50-67-9.

What is the Margin of Safety for Serotonin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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