Hexachlorophene
CAS 70-30-4
Hexachlorophene (CAS 70-30-4) is a Phase 4 pharmaceutical compound with 38 bioactivity targets and 22 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | Potency | 22265.248815165876 nM | 154 | - |
| - | IC50 | 10775.842093023257 nM | 85 | - |
| - | AC50 | 13373.530769230769 nM | 39 | - |
| - | EC50 | 13398.07142857143 nM | 14 | - |
| - | MIC | 0.45249999999999996 ug.mL-1 | 12 | - |
| - | Ki | 2293.46 nM | 10 | - |
| - | MIC | 8135 nM | 8 | - |
| Acetylcholinesterase Enzyme |
IC50 | 5.521 | - | Homo sapiens |
| Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel |
IC50 | 5.212 | - | Sus scrofa |
| Prostaglandin G/H synthase 2 Enzyme |
IC50 | 6.191 | - | Homo sapiens |
| Adenosine receptor A2a GPCR |
Ki | 6.043 | - | Homo sapiens |
| Alpha-2A adrenergic receptor GPCR |
Ki | 5.686 | - | Homo sapiens |
| Sodium-dependent serotonin transporter Transporter |
Ki | 5.636 | - | Homo sapiens |
| 5-hydroxytryptamine receptor 2B GPCR |
Ki | 5.441 | - | Homo sapiens |
| 5-hydroxytryptamine receptor 2C GPCR |
Ki | 5.618 | - | Homo sapiens |
| Alpha-2C adrenergic receptor GPCR |
Ki | 5.994 | - | Homo sapiens |
| Adenosine receptor A3 GPCR |
Ki | 6.442 | - | Homo sapiens |
| Estrogen receptor Nuclear hormone receptor |
IC50 | 5.67 | - | Homo sapiens |
| Estrogen receptor beta Nuclear hormone receptor |
IC50 | 7.01 | - | Homo sapiens |
| Cytochrome P450 1A2 Enzyme |
IC50 | 5.882 | - | Homo sapiens |
| Epidermal growth factor receptor Kinase |
IC50 | 6.126 | - | Homo sapiens |
| Cytochrome P450 2C19 Enzyme |
IC50 | 5.911 | - | Homo sapiens |
| D-lactate dehydrogenase Enzyme |
- | - | - | Escherichia coli (strain K12) |
| Tyrosine-protein kinase Lck Kinase |
IC50 | 5.614 | - | Homo sapiens |
| Tyrosine-protein kinase Fyn Kinase |
IC50 | 5.459 | - | Homo sapiens |
| Receptor tyrosine-protein kinase erbB-2 Kinase |
IC50 | 5.479 | - | Homo sapiens |
| Thromboxane-A synthase Enzyme |
IC50 | 5.51 | - | Homo sapiens |
| Mitogen-activated protein kinase 3 Kinase |
IC50 | 5.605 | - | Homo sapiens |
| Mitogen-activated protein kinase 14 Kinase |
IC50 | 7.057 | - | Homo sapiens |
| Substance-K receptor GPCR |
Ki | 5.86 | - | Homo sapiens |
| Androgen receptor Transcription factor |
Ki | 5.479 | - | Rattus norvegicus |
| Mitogen-activated protein kinase 1 Kinase |
IC50 | 6.708 | - | Homo sapiens |
| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Enzyme |
INHIBITOR | - | - | Escherichia coli (strain K12) |
| Zinc finger protein mex-5 Cytosolic other |
EC50 | 4.72 | - | Caenorhabditis elegans |
| Transitional endoplasmic reticulum ATPase Enzyme |
IC50 | 5.26 | - | Homo sapiens |
| Heat shock cognate 71 kDa protein Unclassified |
IC50 | 4.56 | - | Homo sapiens |
| Heat shock 70 kDa protein 1A Unclassified |
IC50 | 4.72 | - | Homo sapiens |
| M1-family alanyl aminopeptidase Enzyme |
IC50 | 4.24 | - | Plasmodium falciparum (isolate 3D7) |
| Cytoplasmic zinc-finger protein Unclassified |
EC50 | 4.34 | - | Caenorhabditis elegans |
| Envelope glycoprotein gp160 Viral envelope protein |
IC50 | 5.14 | - | Human immunodeficiency virus 1 |
| Macrophage migration inhibitory factor Unclassified |
Ki | 5.26 | - | Homo sapiens |
| N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D Unclassified |
IC50 | 5.01 | - | Homo sapiens |
| 78 kDa glucose-regulated protein Unclassified |
IC50 | 5.04 | - | Homo sapiens |
| Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 Unclassified |
IC50 | 5.14 | - | Human immunodeficiency virus 1 |
| N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-PLD, NAPE-hydrolyzing phospholipase D, EC 3.1.4.54 Unclassified |
IC50 | 4.96 | - | Mus musculus |
IUPHAR Ligand-Target Data
Curated ligand-target interaction rows with action, affinity, and literature identifiers.
| Target | Action | Affinity | PubMed |
|---|---|---|---|
| N -Acylphosphatidylethanolamine-phospholipase D NAPEPLD |
Inhibition | 5.010000228881836 pIC50 | 32284327 |
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| hexachlorophene | 5293 | IN | RXNORM |
Side Effects
SIDER side-effect terms mapped to the drug or same-CAS compound identity.
| Side Effect | Drug Name | MedDRA Type | Concept ID |
|---|---|---|---|
| Dermatitis | hexachlorophene | LLT | C0011603 |
| Dermatitis | hexachlorophene | PT | C0011603 |
| Erythema | hexachlorophene | PT | C0041834 |
| Photosensitivity | hexachlorophene | LLT | C0349506 |
| Photosensitivity reaction | hexachlorophene | PT | C0162830 |
| Redness | hexachlorophene | LLT | C0332575 |
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Hexachlorophene used for in pharmaceutical contexts?
Hexachlorophene (CAS 70-30-4) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Hexachlorophene?
Hexachlorophene has 22 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Discomfort, Disturbance in attention, Dizziness, Drug ineffective, Drug ineffective for unapproved indication. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Hexachlorophene also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Hexachlorophene with EU status "restricted".
What clinical phase is Hexachlorophene in?
Hexachlorophene is rendered with ChEMBL max phase 4 (approved).
What bioactivity targets are documented for Hexachlorophene?
Hexachlorophene has 45 bioactivity rows in this page query. Rendered target entries include Acetylcholinesterase, Sodium/potassium-transporting ATPase subunit alpha-2, Prostaglandin G/H synthase 2, Adenosine receptor A2a, Alpha-2A adrenergic receptor.