Moderate Preservative Sensitization Data

Hexachlorophene

INCI: HEXACHLOROPHENE

CAS Number
70-30-4
Function
Preservative
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Exempt from CIR review due to existing FDA regulation. CIR has reviewed related compounds chlorophene and dichlorophene (data insufficient for safety).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Hexachlorophene based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis

Source: IVDK; SCCS

Expert Verdict

Hexachlorophene is a restricted preservative permitted in the US but subject to concentration limits in the EU due to moderate safety concerns.

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Concern Level: Moderate

Regulatory Flags

EU Restricted endocrine_disruptor eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Hexachlorophene safe in cosmetics?

Hexachlorophene is a restricted preservative permitted in the US but subject to concentration limits in the EU due to moderate safety concerns. The EU classifies Hexachlorophene as "restricted". Safety rating: MODERATE.

Is Hexachlorophene allowed in the EU?

Hexachlorophene EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexachlorophene do in cosmetics?

Hexachlorophene functions as: Preservative. It is classified as a Preservative in our database. CAS number: 70-30-4.

What is the Margin of Safety for Hexachlorophene?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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