SCCS/0881/05 54 NOAEL rows Safety conclusion

Glyoxal (INCI name), Glyoxal

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/0881/05.

Opinion Number

SCCS/0881/05

NOAEL Rows

54

Substances Covered

2

Substance(s) Covered

Glyoxal (INCI name) Glyoxal

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
Glyoxal (INCI name) 107-22-2	NOAEL	0.4	rat inhalation 29 days	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	rat oral	Regulatory source p.38 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	24	Not recorded	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	24	rat inhalation 29 days	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	40 mg/kg bw/day	rat oral 28-day	Regulatory source p.52 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	40 %	rat 28-day	Regulatory source p.55 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	40 mg/kg bw/day	rat 28-day	Regulatory source p.55 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	100 mg/kg bw/day	Not recorded	Regulatory source p.20 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	100 mg/kg bw	rat oral 28 day	Regulatory source p.49 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	100 mg/kg bw	rat oral 28 day	Regulatory source p.49 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	100 mg/kg bw	rat oral 28 days	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	107 mg/kg bw	Not recorded	Regulatory source p.22 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	107 mg/kg bw	rat oral 90 days	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	115 mg/kg bw	rat oral 90 days	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	115 mg/kg bw	dog oral 90 days	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	132 mg/kg bw	rat oral 90 days	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name)	DERMAL_ABSORPTION	100 %	in vitro dermal	SCCS Opinion p.53 SCCS Opinion
Glyoxal (INCI name)	DERMAL_ABSORPTION	100 %	in vitro dermal	SCCS Opinion p.53 SCCS Opinion
Glyoxal (INCI name)	DERMAL_ABSORPTION	100 %	in vitro dermal	SCCS Opinion p.53 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	881	developmental toxicity rabbit oral Developmental	SCCS Opinion p.44 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	881	developmental toxicity rabbit oral Developmental	SCCS Opinion p.44 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	881	developmental toxicity rabbit oral Developmental	SCCS Opinion p.44 SCCS Opinion
Glyoxal (INCI name) 107-22-2	NOAEL	881	developmental toxicity rabbit oral Developmental	SCCS Opinion p.44 SCCS Opinion
Glyoxal (INCI name) 107-22-2	carcinogenicity	40 %	carcinogenicity rat oral 28-day	Regulatory source p.52 SCCS Opinion
Glyoxal (INCI name) 107-22-2	developmental toxicity	40 %	developmental toxicity rat oral developmental	Regulatory source p.44 SCCS Opinion
Glyoxal (INCI name) 107-22-2	developmental toxicity	881	developmental toxicity rabbit oral Developmental	Regulatory source p.44 SCCS Opinion
Glyoxal (INCI name) 107-22-2	genotoxicity	5 mg/kg bw	genotoxicity rat oral	Regulatory source p.39 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	25 mg/kg bw	repeated dose toxicity prenatal	Regulatory source p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	25 mg/kg bw	repeated dose toxicity 90 days	Regulatory source p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	25 mg/kg bw	repeated dose toxicity rat 90-day	Regulatory source p.52 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	25 mg/kg bw	repeated dose toxicity rat oral 90-day	Regulatory source p.55 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	40 %	repeated dose toxicity rat oral 90-day	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	40 %	repeated dose toxicity rat oral 90-day	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	115 mg/kg bw	repeated dose toxicity rat oral 90-day	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	115 mg/kg bw	repeated dose toxicity rat oral 90-day	Regulatory source p.24 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	125 mg/kg bw	repeated dose toxicity prenatal	Regulatory source p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	125 mg/kg bw	repeated dose toxicity prenatal	Regulatory source p.46 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	125 mg/kg bw	repeated dose toxicity rat 90-day	Regulatory source p.52 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	125 mg/kg bw	repeated dose toxicity rat 90-day	Regulatory source p.55 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	127 mg/kg bw/day	repeated dose toxicity rat 28-day	Regulatory source p.52 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	127 mg/kg bw/day	repeated dose toxicity rat 28-day	Regulatory source p.55 SCCS Opinion
Glyoxal (INCI name) 107-22-2	repeated dose toxicity	1000 mg/kg bw	repeated dose toxicity rat oral 90-day	Regulatory source p.24 SCCS Opinion

Safety Conclusion

sccs_opinions Max 1.0%

safe

Key concerns: secondary amine; nitrosamine <50ppb; sensitisation not excluded

Opinion date: 17 March 2006

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en