SCCS/1106/07 12 NOAEL rows Safety conclusion

codes............................................7, s with respect to their impact on consumer, Ethyl lauroyl arginate HCl (COLIPA P95)

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1106/07.

Opinion Number

SCCS/1106/07

NOAEL Rows

Substances Covered

Substance(s) Covered

codes............................................7 s with respect to their impact on consumer Ethyl lauroyl arginate HCl (COLIPA P95)

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
codes............................................7 60372-77-2	NOAEL	0.442 mg/kg bw/day	NOAEL study oral 9 years	SCCS Opinion p.18
codes............................................7 60372-77-2	NOAEL	0.442 mg/kg bw/day	NOAEL study oral 9 years	SCCS Opinion p.18
codes............................................7 60372-77-2	NOAEL	0.442 mg/kg bw/day	NOAEL study oral 9 years	SCCS Opinion p.18
codes............................................7 60372-77-2	NOAEL	0.442 mg/kg bw/day	NOAEL study oral 9 years	SCCS Opinion p.18
codes............................................7 60372-77-2	NOAEL	56 mg/kg bw/day	NOAEL study rat oral 13-week	SCCS Opinion p.18
codes............................................7 60372-77-2	NOAEL	56 mg/kg bw/day	NOAEL study rat oral 13-week	SCCS Opinion p.18
codes............................................7 60372-77-2	NOAEL	56 mg/kg bw/day	NOAEL study rat oral 13-week	SCCS Opinion p.18
codes............................................7 60372-77-2	NOAEL	56 mg/kg bw/day	NOAEL study rat oral 13-week	SCCS Opinion p.18
s with respect to their impact on consumer 60372-77-2	NOAEL	271 mg/kg bw/day	NOAEL study oral 28 day	SCCS Opinion p.31
s with respect to their impact on consumer 60372-77-2	NOAEL	271 mg/kg bw/day	NOAEL study oral 28 day	SCCS Opinion p.31
s with respect to their impact on consumer 60372-77-2	NOAEL	271 mg/kg bw/day	NOAEL study oral 28 day	SCCS Opinion p.31
s with respect to their impact on consumer 60372-77-2	NOAEL	271 mg/kg bw/day	NOAEL study oral 28 day	SCCS Opinion p.31

Safety Conclusion

sccs_opinions Max 0.4% as preservative; 0.8% in soap, anti-dandruff shampoos, non-spray deodorants

The SCCP considers, with the additional data provided, that Ethyl Lauroyl Arginate HCl is safe for the consumers, when used: - up to a maximum authorised concentration of 0.4 % as a preservative in cosmetic products, but excluding products for the lips, oral hygiene products and spray products - up to a maximum authorised concentration of 0.8 % in soap, anti-dandruff shampoos, and non-spray deodorants.

Key concerns: Opinion based only on use in the specified cosmetic products; takes no account of other possible/probable consumer exposure sources to the substance.

Opinion date: 2008-04-15

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en