SCCS/1120/07 13 NOAEL rows Safety conclusion

5-Amino-4-chloro-o-cresol HCl

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1120/07.

Opinion Number

SCCS/1120/07

NOAEL Rows

13

Substances Covered

1

Substance(s) Covered

5-Amino-4-chloro-o-cresol HCl

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
5-Amino-4-chloro-o-cresol HCl 110102-85-7	NOAEL	500 mg/kg bw/day	developmental toxicity human oral	SCCS Opinion p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	NOAEL	500 mg/kg bw/day	developmental toxicity human oral	SCCS Opinion p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	NOAEL	500 mg/kg bw/day	developmental toxicity human oral	SCCS Opinion p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	NOAEL	500 mg/kg bw/day	developmental toxicity human oral	SCCS Opinion p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	dermal absorption	0.19 mg/kg	dermal absorption rat oral 90-day	Regulatory source p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	dermal absorption	180 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	dermal absorption	180 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	developmental toxicity	500 mg/kg bw/day	developmental toxicity human oral	Regulatory source p.19 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	genotoxicity	180 mg/kg bw/day	genotoxicity rat Chronic	Regulatory source p.14 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	genotoxicity	180 mg/kg bw/day	genotoxicity rat Chronic	Regulatory source p.14 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	irritation	180 mg/kg bw/day	irritation rat 90-day	Regulatory source p.20 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	irritation	180 mg/kg bw/day	irritation rat 90-day	Regulatory source p.20 SCCS Opinion
5-Amino-4-chloro-o-cresol HCl 110102-85-7	irritation	180 mg/kg bw/day	irritation rat 90-day	Regulatory source p.20 SCCS Opinion

Safety Conclusion

sccs_opinions Max 1.0%

safe

Key concerns: secondary amine; nitrosamine <50ppb; sensitisation not excluded

Opinion date: 18 December 2007

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en