SCCS/1160/08 20 NOAEL rows Safety conclusion

Acid Yellow 1

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1160/08.

Opinion Number

SCCS/1160/08

NOAEL Rows

Substances Covered

Substance(s) Covered

Acid Yellow 1

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
Acid Yellow 1 846-70-8	NOAEL	0.0011 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	NOAEL	0.0011 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	NOAEL	0.0011 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	NOAEL	0.0011 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	NOAEL	30 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	NOAEL	30 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	NOAEL	30 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	NOAEL	30 mg/kg bw	dermal absorption rat oral 90-day	SCCS Opinion p.23 SCCS Opinion
Acid Yellow 1 846-70-8	dermal absorption	0.0009 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	dermal absorption	0.0011 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	dermal absorption	30 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	dermal absorption	30 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	dermal absorption	30 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	dermal absorption	30 mg/kg bw	dermal absorption rat oral 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	developmental toxicity	30 mg/kg bw/day	developmental toxicity human 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	developmental toxicity	30 mg/kg bw/day	developmental toxicity human 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	developmental toxicity	50 mg/kg bw/day	developmental toxicity human developmental	Regulatory source p.22 SCCS Opinion
Acid Yellow 1 846-70-8	developmental toxicity	50 mg/kg bw/day	developmental toxicity human 90-day	Regulatory source p.23 SCCS Opinion
Acid Yellow 1 846-70-8	genotoxicity	30 mg/kg bw/day	genotoxicity Chronic	Regulatory source p.17 SCCS Opinion
Acid Yellow 1 846-70-8	genotoxicity	30 mg/kg bw/day	genotoxicity Chronic	Regulatory source p.17 SCCS Opinion

Safety Conclusion

sccs_opinions Max 1.0% on-head (oxidative); 0.2% on-head (non-oxidative)

The SCCP is of the opinion that, apart from the risks associated with the use of a sensitiser, the use of Acid Yellow 1 as an ingredient in oxidative hair dye formulations at a maximum on-head concentration of 1.0% and in non-oxidative hair dye formulations at a maximum on-head concentration of 0.2% does not pose a risk to the health of the consumer.

Key concerns: Considered a potent skin sensitiser. The stability of Acid Yellow 1 in oxidative hair dye formulations has not been demonstrated.

Opinion date: 2008-12-16

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en