Is Acid Yellow 1 safe in cosmetics?
Acid Yellow 1 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Acid Yellow 1
Also known as: 2-Naphthalenesulfonic acid, 8-hydroxy-5,7-dinitro-, sodium salt (1:2), 2-Naphthalenesulfonic acid, 5,7-dinitro-8-hydroxy-, disodium salt, C.I. Acid Yellow 1, disodium 5,7-dinitro-8-oxidonaphthalene-2-sulphonate, 1307 Yellow (+15 more)
INCI: CI 10316
Acid Yellow 1 (CAS 846-70-8) is a cosmetic cosmetic ingredient functioning as Colorant (nitro dye; Naphthol Yellow S). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 846-70-8 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant (nitro dye; Naphthol Yellow S)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
disodium;5,7-dinitro-8-oxidonaphthalene-2-sulfonate
InChIKey
CTIQLGJVGNGFEW-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Ext. D&C Yellow No. 7 — listed for externally applied drugs and cosmetics; certification required
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Yellow 1.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acid Yellow 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | - | pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | - | pig | developmental toxicity | SCCNFP_vision_codex |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Yellow
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 0,2%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0,2%
India: Permitted Colorant
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.096% | - | - | 2008-12-16 |
| measured_sccs_opinion | 0.078% | - | - | 2008-12-16 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "D&C Yellow No. 10", "Chemical_Name": "Quinoline Yellow", "CAS_Number": "8004-92-0", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "External use only", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.710", "Notes": "Not for mucous membranes"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Acid Yellow 1.
Regulatory Flags
colorant
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Yellow 1 by CAS number or substance name.
Studies
32
Lowest NOAEL
0
Highest NOAEL
50
Units vary across source rows: mg/kg bw/day, mg/kg bw
SCCS_vision_codex
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.096% | SCCS opinion extraction | - |
| 0.078% | SCCS opinion extraction | - |
Known Synonyms
2-Naphthalenesulfonic acid, 8-hydroxy-5,7-dinitro-, sodium salt (1:2)
2-Naphthalenesulfonic acid, 5,7-dinitro-8-hydroxy-, disodium salt
C.I. Acid Yellow 1
disodium 5,7-dinitro-8-oxidonaphthalene-2-sulphonate
1307 Yellow
1422 Yellow
A.F. Yellow No. 1
Acid Leather Yellow NYS
Amacid Yellow S
Calcocid Yellow S
Dolkwal Naphthol Yellow S
Edicol Supra Yellow Y
EINECS 212-690-2
Ext D and C Yellow No. 7
Ext D&C Yellow 7
FD and C Yellow No. 1
Flavianic acid disodium salt
Hispacid Yellow NSF
Japan Yellow 403-1
Japan Yellow No. 403-1
Chemical Function
Dye
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Acid Yellow 1 allowed in the EU?
Acid Yellow 1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Yellow 1 do in cosmetics?
Acid Yellow 1 functions as: Colorant (nitro dye; Naphthol Yellow S). It is classified as a cosmetic ingredient in our database. CAS number: 846-70-8.
What is the NOAEL for Acid Yellow 1?
The NOAEL (No Observed Adverse Effect Level) for Acid Yellow 1 is =0 mg/kg bw/day based on a developmental toxicity study via oral route in guinea pig. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is Acid Yellow 1 used outside cosmetics?
Acid Yellow 1 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acid Yellow 1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
CI 10316 (Ext. D&C Yellow No. 7)
Moderate
Chemical family
Colorant. Synthetic nitro dye (Disodi...
ACID RED 27
Moderate
Browse nearby
Hair Dyeing
ACID RED 51
Moderate
Browse nearby
Colorant, Hair Dyeing
Is Acid Yellow 1 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Acid Yellow 1 in your formulation.