sccs_opinions
Max 1.0%
safe
Key concerns: sensitisation potential not excluded
Opinion date: 16 December 2008
SCCS/1181/08
12 NOAEL rows
Safety conclusion
s with respect to their impact on consumer, Diethylene glycol (DEG)
Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1181/08.
Opinion Number
SCCS/1181/08
NOAEL Rows
12
Substances Covered
2
Substance(s) Covered
s with respect to their impact on consumer
Diethylene glycol (DEG)
NOAEL Values Extracted from This Opinion
| Substance | Endpoint | Value | Study | Source |
|---|---|---|---|---|
|
s with respect to their impact on consumer
111-46-6
|
NOAEL | 1.6 mg/kg bw/day |
dermal chronic |
Regulatory source
p.23
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
NOAEL | 10 | rat |
Regulatory source
p.10
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
NOAEL | 50 mg/kg bw/day |
rat oral 225 days |
Regulatory source
p.9
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
NOAEL | 200 mg/kg/day | rat |
Regulatory source
p.10
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
developmental toxicity | 559 mg/kg bw/day |
developmental toxicity rat oral developmental |
Regulatory source
p.13
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
developmental toxicity | 1118 mg/kg bw/day |
developmental toxicity rat oral developmental |
Regulatory source
p.14
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
genotoxicity | 50 mg/kg bw/day |
genotoxicity rat |
Regulatory source
p.10
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
genotoxicity | 200 mg/kg bw/day |
genotoxicity rat |
Regulatory source
p.10
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
genotoxicity | 200 mg/kg bw/day |
genotoxicity rat |
Regulatory source
p.10
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
repeated dose toxicity | 50 mg/kg bw/day |
repeated dose toxicity rat |
Regulatory source
p.19
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
reproductive toxicity | 50 mg/kg bw/day |
reproductive toxicity rat oral |
Regulatory source
p.22
SCCS Opinion
|
|
s with respect to their impact on consumer
111-46-6
|
reproductive toxicity | 612 mg/kg bw/day |
reproductive toxicity rat oral |
Regulatory source
p.22
SCCS Opinion
|