SCCS/1390/10 24 NOAEL rows Safety conclusion

Toluene-2,5-diamine and its sulfate

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1390/10.

Opinion Number
SCCS/1390/10
NOAEL Rows
24
Substances Covered
1

Substance(s) Covered

Toluene-2,5-diamine and its sulfate

NOAEL Values Extracted from This Opinion

Substance Endpoint Value Study Source
95-70-5
95-70-5
 NOAEL 2.5 mg/kg bw/d rat
oral
12-week
Regulatory source
p.32
SCCS Opinion
95-70-5
95-70-5
 NOAEL 2.5 mg/kg bw/d rat
oral
28-day
Regulatory source
p.33
SCCS Opinion
95-70-5
95-70-5
 NOAEL 2.5 mg/kg rat
oral
Regulatory source
p.58
SCCS Opinion
95-70-5
95-70-5
 NOAEL 10 mg/kg bw/d 3-day
Regulatory source
p.33
SCCS Opinion
95-70-5
95-70-5
 NOAEL 10 mg/kg bw/d oral
28-day
Regulatory source
p.34
SCCS Opinion
95-70-5
95-70-5
 NOAEL 10 mg/kg rat
oral
91-day
Regulatory source
p.59
SCCS Opinion
95-70-5
95-70-5
 NOAEL 10 mg/kg rat
oral
91-day
Regulatory source
p.62
SCCS Opinion
95-70-5
95-70-5
 NOAEL 50 mg/kg bw/d rat
oral
Regulatory source
p.49
SCCS Opinion
95-70-5
95-70-5
 NOAEL 50 mg/kg bw/d rat
Regulatory source
p.50
SCCS Opinion
95-70-5
95-70-5
 NOAEL 60 mg/kg bw/d Not recorded
Regulatory source
p.31
SCCS Opinion
95-70-5
95-70-5
 carcinogenicity 10 mg/kg bw/d carcinogenicity
rat
oral
90-day
Regulatory source
p.63
SCCS Opinion
95-70-5
95-70-5
 carcinogenicity 69 % carcinogenicity
rat
oral
90-day
Regulatory source
p.63
SCCS Opinion
95-70-5
95-70-5
 dermal absorption 0.67 mg/kg dermal absorption
rat
oral
90-day
Regulatory source
p.60
SCCS Opinion
95-70-5
95-70-5
 dermal absorption 10 mg/kg dermal absorption
rat
oral
91-day
Regulatory source
p.59
SCCS Opinion
95-70-5
95-70-5
 dermal absorption 10 mg/kg dermal absorption
rat
oral
90-day
Regulatory source
p.60
SCCS Opinion
95-70-5
95-70-5
 dermal absorption 10 mg/kg dermal absorption
rat
oral
90-day
Regulatory source
p.60
SCCS Opinion
95-70-5
95-70-5
 dermal absorption 10 mg/kg dermal absorption
rat
oral
91-day
Regulatory source
p.62
SCCS Opinion
95-70-5
95-70-5
 dermal absorption 69 % dermal absorption
rat
oral
90-day
Regulatory source
p.60
SCCS Opinion
95-70-5
95-70-5
 reproductive toxicity 10 mg/kg bw/d reproductive toxicity
rat
oral
90-day
Regulatory source
p.61
SCCS Opinion
95-70-5
95-70-5
 reproductive toxicity 20 mg/kg bw/d reproductive toxicity
rat
oral
90-day
Regulatory source
p.61
SCCS Opinion
95-70-5
95-70-5
 reproductive toxicity 45 mg/kg bw/d reproductive toxicity
rabbit
oral
Regulatory source
p.48
SCCS Opinion
95-70-5
95-70-5
 reproductive toxicity 45 mg/kg reproductive toxicity
rat
oral
90-day
Regulatory source
p.61
SCCS Opinion
95-70-5
95-70-5
 reproductive toxicity 50 mg/kg bw/d reproductive toxicity
rat
oral
90-day
Regulatory source
p.61
SCCS Opinion
95-70-5
95-70-5
 reproductive toxicity 50 mg/kg bw/d reproductive toxicity
rat
oral
90-day
Regulatory source
p.61
SCCS Opinion

Safety Conclusion

sccs_opinions Max 1.25%
safe with restrictions

Key concerns: sensitising potential; use with caution in persons with thyroid conditions

Opinion date: 23 March 2010

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en