SCCS/1425/11 9 NOAEL rows Safety conclusion

2,6-Dihydroxyethylaminotoluene

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1425/11.

Opinion Number

SCCS/1425/11

NOAEL Rows

Substances Covered

Substance(s) Covered

2,6-Dihydroxyethylaminotoluene

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
2,6-Dihydroxyethylaminotoluene 149330-25-6	NOAEL	200 mg/kg bw	rat oral	Regulatory source p.21 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	NOAEL	200 mg/kg bw	rat oral	Regulatory source p.24 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	NOAEL	100 mg/kg bw/d	genotoxicity Chronic	SCCS Opinion p.15 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	NOAEL	100 mg/kg bw/d	genotoxicity Chronic	SCCS Opinion p.15 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	NOAEL	100 mg/kg bw/d	genotoxicity Chronic	SCCS Opinion p.15 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	NOAEL	100 mg/kg bw/d	genotoxicity Chronic	SCCS Opinion p.15 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	genotoxicity	100 mg/kg bw/d	genotoxicity Chronic	Regulatory source p.15 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	reproductive toxicity	0 mg/kg bw	reproductive toxicity rat oral 90 day	Regulatory source p.24 SCCS Opinion
2,6-Dihydroxyethylaminotoluene 149330-25-6	reproductive toxicity	200 mg/kg bw/d	reproductive toxicity rat oral 90 day	Regulatory source p.24 SCCS Opinion

Safety Conclusion

sccs_opinions Max None established (cannot be assessed)

insufficient data

Key concerns: Insufficient dermal toxicity data; low oral bioavailability indicated; secondary amine prone to nitrosation; no inhalation data; 90-day dermal toxicity study required

Opinion date: 22 March 2011

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en