SCCS/1510/13 4 NOAEL rows Safety conclusion

2-Chloro-p-phenylenediamine (A8)

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1510/13.

Opinion Number

SCCS/1510/13

NOAEL Rows

4

Substances Covered

1

Substance(s) Covered

2-Chloro-p-phenylenediamine (A8)

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
615-66-7 615-66-7	developmental toxicity	100 mg/kg bw/d	developmental toxicity rat developmental	Regulatory source p.18 SCCS Opinion
615-66-7 615-66-7	developmental toxicity	200 mg/kg bw/d	developmental toxicity rat developmental	Regulatory source p.18 SCCS Opinion
615-66-7 615-66-7	repeated dose toxicity	100 mg/kg bw/d	repeated dose toxicity rat subchronic	Regulatory source p.19 SCCS Opinion
615-66-7 615-66-7	repeated dose toxicity	200 mg/kg bw/d	repeated dose toxicity rat subchronic	Regulatory source p.19 SCCS Opinion

Safety Conclusion

sccs_opinions

not safe

Key concerns: genotoxicity potential; strong sensitiser

Opinion date: 19 September 2013

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en