SCCS/1513/13 16 NOAEL rows Safety conclusion

3-Benzylidene camphor, 3-Benzilydene camphor (S61)

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1513/13.

Opinion Number

SCCS/1513/13

NOAEL Rows

Substances Covered

Substance(s) Covered

3-Benzylidene camphor 3-Benzilydene camphor (S61)

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
3-Benzylidene camphor 15087-24-8	NOAEL	0.21 mg/kg bw	rat oral	Regulatory source p.24 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	2 %	rat	Regulatory source p.24 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	2 %	rat oral 4 week	Regulatory source p.26 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	7.5 mg/kg bw/d	rat oral	Regulatory source p.24 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	15 mg/kg bw/day	mouse oral 56 day	Regulatory source p.15 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	15 mg/kg bw/day	mouse oral 56 day	Regulatory source p.15 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	15 mg/kg bw/d	rat oral	Regulatory source p.24 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	18	human dermal	Regulatory source p.5 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	18	human dermal	Regulatory source p.5 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	25 mg/kg bw/d	guinea pig oral 15 days	Regulatory source p.12 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	50 mg/kg bw/day	45 d	Regulatory source p.15 SCCS Opinion
3-Benzylidene camphor 15087-24-8	NOAEL	50 %	rat oral	Regulatory source p.24 SCCS Opinion
3-Benzylidene camphor 15087-24-8	genotoxicity	40 mg/kg bw/day	genotoxicity 38 weeks	Regulatory source p.13 SCCS Opinion
3-Benzylidene camphor 15087-24-8	repeated dose toxicity	250 mg/kg bw/d	repeated dose toxicity rat oral sub-chronic	Regulatory source p.11 SCCS Opinion
3-Benzylidene camphor 15087-24-8	reproductive toxicity	15 mg/kg bw/day	reproductive toxicity rat	Regulatory source p.25 SCCS Opinion
3-Benzylidene camphor 15087-24-8	reproductive toxicity	20 mg/kg bw/day	reproductive toxicity rat oral 6 week	Regulatory source p.25 SCCS Opinion

Safety Conclusion

sccs_opinions Max Not safe at any recommended level

not safe (endocrine disrupting)

Key concerns: Estrogenic endocrine disruptor; not permitted in EU cosmetics (removed from Annex VI UV filters)

Opinion date: 18 June 2013

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en