SCCS/1520/13 29 NOAEL rows Safety conclusion

s. Hair dye products containing these substances must be, Thioglycolic acid and its salts (TGA)

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1520/13.

Opinion Number

SCCS/1520/13

NOAEL Rows

Substances Covered

Substance(s) Covered

s. Hair dye products containing these substances must be Thioglycolic acid and its salts (TGA)

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
s. Hair dye products containing these substances must be 68-11-1	NOAEL	1.66 mg/kg bw	rat dermal 5 year	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	11 %	rat dermal 13 weeks	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	129 mg/kg bw/d	rat dermal 13 weeks	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	180 mg/kg bw/d	rat dermal 5 year	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	65 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	65 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	65 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	65 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	100 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	100 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	100 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	NOAEL	100 mg/kg bw/day	reproductive toxicity rat oral developmental	SCCS Opinion p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	dermal absorption	0.044 mg/kg bw	dermal absorption rat dermal 13 weeks	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	dermal absorption	129 mg/kg bw/d	dermal absorption rat dermal 5 days	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	dermal absorption	129 mg/kg bw/d	dermal absorption rat dermal 13 weeks	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	dermal absorption	180 mg/kg bw/d	dermal absorption rat dermal 13 weeks	Regulatory source p.32 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	7 mg/kg bw/d	repeated dose toxicity rat oral 7 days	Regulatory source p.23 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	11.25 mg/kg bw/d	repeated dose toxicity rat dermal 90 days	Regulatory source p.23 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	11.25 mg/kg bw/d	repeated dose toxicity rat oral 5 days	Regulatory source p.33 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	20 mg/kg bw/d	repeated dose toxicity rat oral 7 days	Regulatory source p.23 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	20 mg/kg bw/d	repeated dose toxicity rat dermal developmental	Regulatory source p.29 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	45 mg/kg bw/d	repeated dose toxicity rat oral 5 days	Regulatory source p.23 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	80 mg/kg bw/d	repeated dose toxicity rat dermal developmental	Regulatory source p.29 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	80 mg/kg bw/d	repeated dose toxicity rat dermal developmental	Regulatory source p.29 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	180 mg/kg bw/d	repeated dose toxicity rat dermal 90 days	Regulatory source p.23 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	repeated dose toxicity	180 mg/kg bw/d	repeated dose toxicity rat oral 5 days	Regulatory source p.33 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	reproductive toxicity	20 mg/kg bw/d	reproductive toxicity developmental	Regulatory source p.29 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	reproductive toxicity	65 mg/kg bw/day	reproductive toxicity rat oral developmental	Regulatory source p.30 SCCS Opinion
s. Hair dye products containing these substances must be 68-11-1	reproductive toxicity	100 mg/kg bw/day	reproductive toxicity rat oral developmental	Regulatory source p.30 SCCS Opinion

Safety Conclusion

sccs_opinions Max Hair products: 11% (as TGA); Cold wave: 11% (professional); General cosmetics: 8%

safe with restrictions

Key concerns: Skin irritation potential; thioglycolic acid is caustic; concentration limits differ for professional vs consumer use

Opinion date: 11 November 2013

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en