SCCS/1529/14 12 NOAEL rows Safety conclusion

3-amino-2,6-dimethylphenol, 3-amino-2,6-dimethylphenol (A162)

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1529/14.

Opinion Number

SCCS/1529/14

NOAEL Rows

Substances Covered

Substance(s) Covered

3-amino-2,6-dimethylphenol 3-amino-2,6-dimethylphenol (A162)

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
3-amino-2,6-dimethylphenol 6994-64-5	NOAEL	150 mg/kg bw/day	Not recorded	Regulatory source p.26 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	NOAEL	150 mg/kg bw/day	Not recorded	Regulatory source p.26 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	NOAEL	150 mg/kg bw/day	human	Regulatory source p.27 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	developmental toxicity	0.08 mg/kg bw	developmental toxicity rat dermal prenatal	Regulatory source p.34 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	developmental toxicity	60 mg/kg bw/d	developmental toxicity rat dermal prenatal	Regulatory source p.34 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	developmental toxicity	60 mg/kg bw/d	developmental toxicity rat oral prenatal	Regulatory source p.34 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	genotoxicity	70 mg/kg bw/day	genotoxicity rat Chronic	Regulatory source p.21 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	genotoxicity	70 mg/kg bw/day	genotoxicity rat Chronic	Regulatory source p.21 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	reproductive toxicity	60 mg/kg bw/day	reproductive toxicity rat oral 14 days	Regulatory source p.34 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	reproductive toxicity	60 mg/kg bw/day	reproductive toxicity rat oral 14 days	Regulatory source p.34 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	reproductive toxicity	70 mg/kg bw/day	reproductive toxicity rat oral 14 days	Regulatory source p.34 SCCS Opinion
3-amino-2,6-dimethylphenol 6994-64-5	reproductive toxicity	2000 mg/kg bw	reproductive toxicity rat oral 14 days	Regulatory source p.34 SCCS Opinion

Safety Conclusion

sccs_opinions Max 2.0%

safe

Key concerns: sensitisation potential not excluded

Opinion date: 18 June 2014

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en