Is 3-Amino-2,6-Dimethylphenol safe in cosmetics?
3-Amino-2,6-Dimethylphenol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
3-Amino-2,6-Dimethylphenol
Also known as: EINECS 230-268-6, UNII-KK52J0MQ7D
INCI: 3-AMINO-2,6-DIMETHYLPHENOL
3-Amino-2,6-Dimethylphenol (CAS 6994-64-5) is a cosmetic cosmetic ingredient functioning as Hair dyeing — oxidative hair dye precursor (COLIPA No. A162). NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Function
Hair dyeing — oxidative hair dye precursor (COLIPA No. A162)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
3-amino-2,6-dimethylphenol
InChIKey
XSBKXUJEVYHSNO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Coal tar hair dye exemption under FD&C Act §601(a)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Amino-2,6-Dimethylphenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 3-Amino-2,6-Dimethylphenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =60 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =60 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS Opinion |
| NOAEL | =60 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =60 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS Opinion |
| NOAEL | =60 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =60 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS Opinion |
Pre-Calculated Safety Assessment
Conditional — safe only within SCCS limits: oxidative hair dye; intended max on-head 2.0%; sensitisation potential cannot be excluded
Pre-calculated NOAEL → SED → MoS audit trail for 3-Amino-2,6-Dimethylphenol across SCCS product categories, with measured dermal absorption where available.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in oxidative hair dye products.
BRIN Brazil/India Cosmetics
India: Restricted
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 2.0% | in_vitro | - | SCCS/0151 |
| measured | 1.0% | - | - | SCCS/0151 |
| measured | 72.0% | - | - | SCCS/0151 |
| measured | 1.1% | - | - | SCCS/0151 |
| measured | 73.0% | - | - | SCCS/0151 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for 3-Amino-2,6-Dimethylphenol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 3-Amino-2,6-Dimethylphenol by CAS number or substance name.
Studies
24
Lowest NOAEL
0.08
Highest NOAEL
2000
Units vary across source rows: mg/kg bw, mg/kg bw/d, mg/kg bw/day
SCCS Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 2.0% | in_vitro | - |
| 1.0% | - | - |
| 72.0% | - | - |
| 1.1% | - | - |
| 73.0% | - | - |
Known Synonyms
EINECS 230-268-6
UNII-KK52J0MQ7D
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Frequently Asked Questions
Is 3-Amino-2,6-Dimethylphenol allowed in the EU?
3-Amino-2,6-Dimethylphenol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Amino-2,6-Dimethylphenol do in cosmetics?
3-Amino-2,6-Dimethylphenol functions as: Hair dyeing — oxidative hair dye precursor (COLIPA No. A162). It is classified as a cosmetic ingredient in our database. CAS number: 6994-64-5.
What is the NOAEL for 3-Amino-2,6-Dimethylphenol?
The NOAEL (No Observed Adverse Effect Level) for 3-Amino-2,6-Dimethylphenol is =0.08 mg/kg bw based on a developmental toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Is 3-Amino-2,6-Dimethylphenol used outside cosmetics?
3-Amino-2,6-Dimethylphenol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 3-Amino-2,6-Dimethylphenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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