Is 3-Amino-2,6-Dimethylphenol safe in cosmetics?
3-Amino-2,6-Dimethylphenol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
3-Amino-2,6-Dimethylphenol
Also known as: EINECS 230-268-6, UNII-KK52J0MQ7D
INCI: 3-AMINO-2,6-DIMETHYLPHENOL
3-Amino-2,6-Dimethylphenol (CAS 6994-64-5) is a cosmetic cosmetic ingredient functioning as Hair dyeing — oxidative hair dye precursor (COLIPA No. A162). NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 6994-64-5 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing — oxidative hair dye precursor (COLIPA No. A162)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-amino-2,6-dimethylphenol
InChIKey
XSBKXUJEVYHSNO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Coal tar hair dye exemption under FD&C Act §601(a)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Amino-2,6-Dimethylphenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 3-Amino-2,6-Dimethylphenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =0.08 mg/kg bw | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/d | dermal | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 3-Amino-2,6-Dimethylphenol across SCCS product categories, with measured dermal absorption where available.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in oxidative hair dye products.
BRIN Brazil/India Cosmetics
India: Restricted
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 2.0% | in_vitro | - | SCCS/0151 |
| measured | 1.0% | - | - | SCCS/0151 |
| measured | 72.0% | - | - | SCCS/0151 |
| measured | 1.1% | - | - | SCCS/0151 |
| measured | 73.0% | - | - | SCCS/0151 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "6994-64-5", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "other", "molecular_weight_Da": "137.18", "color_result_on_hair": "Brown modifier", "shade_range": "brown", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex", "sensitiza…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 3-Amino-2,6-Dimethylphenol.
Regulatory Flags
potential-allergen
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 3-Amino-2,6-Dimethylphenol by CAS number or substance name.
Studies
24
Lowest NOAEL
0.08
Highest NOAEL
2000
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg bw/d
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 2.0% | in_vitro | - |
| 1.0% | - | - |
| 72.0% | - | - |
| 1.1% | - | - |
| 73.0% | - | - |
Known Synonyms
EINECS 230-268-6
UNII-KK52J0MQ7D
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Frequently Asked Questions
Is 3-Amino-2,6-Dimethylphenol allowed in the EU?
3-Amino-2,6-Dimethylphenol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Amino-2,6-Dimethylphenol do in cosmetics?
3-Amino-2,6-Dimethylphenol functions as: Hair dyeing — oxidative hair dye precursor (COLIPA No. A162). It is classified as a cosmetic ingredient in our database. CAS number: 6994-64-5.
What is the NOAEL for 3-Amino-2,6-Dimethylphenol?
The NOAEL (No Observed Adverse Effect Level) for 3-Amino-2,6-Dimethylphenol is =0.08 mg/kg bw based on a developmental toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 3-Amino-2,6-Dimethylphenol used outside cosmetics?
3-Amino-2,6-Dimethylphenol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 3-Amino-2,6-Dimethylphenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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