SCCS/1650/23 49 NOAEL rows Safety conclusion

Silver Zinc Zeolite, codes ........................................................... 12

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1650/23.

Opinion Number

SCCS/1650/23

NOAEL Rows

Substances Covered

Substance(s) Covered

Silver Zinc Zeolite codes ........................................................... 12

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
Silver Zinc Zeolite 130328-20-0	NOAEL	0.0045 mg/kg bw/d	human inhalation 90-day	Regulatory source p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	0.0065 mg/kg bw/d	human oral 70 years	Regulatory source p.24 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	0.04	inhalation	Regulatory source p.18 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	3.3	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	3.3	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	3.5	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	3.5	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	4.5	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	5 %	rat oral 24 months	Regulatory source p.24 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	5 %	rat oral 24 months	Regulatory source p.24 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	5	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31.52 mg/kg bw	human oral	Regulatory source p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31.52 mg/kg bw	human oral	Regulatory source p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31.52 mg/kg bw	human oral	Regulatory source p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	275	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	2017	dermal	Regulatory source p.31 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31.52 mg/kg bw	NOAEL study human oral	SCCS Opinion p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31.52 mg/kg bw	NOAEL study human oral	SCCS Opinion p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31.52 mg/kg bw	NOAEL study human oral	SCCS Opinion p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	NOAEL	31.52 mg/kg bw	NOAEL study human oral	SCCS Opinion p.25 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	developmental toxicity	100 mg/kg bw/d	developmental toxicity rat developmental	Regulatory source p.26 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	repeated dose toxicity	0.0045 mg/kg bw/d	repeated dose toxicity rat inhalation chronic	Regulatory source p.33 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	repeated dose toxicity	50 mg/kg bw/day	repeated dose toxicity rat subchronic	Regulatory source p.23 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	repeated dose toxicity	250 mg/kg bw/d	repeated dose toxicity dog subchronic	Regulatory source p.23 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	reproductive toxicity	20	reproductive toxicity oral developmental	Regulatory source p.26 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	reproductive toxicity	200 mg/kg bw/d	reproductive toxicity human oral	Regulatory source p.30 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	reproductive toxicity	1000 mg/kg bw	reproductive toxicity oral developmental	Regulatory source p.33 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	reproductive toxicity	1000 mg/kg bw	reproductive toxicity oral developmental	Regulatory source p.33 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	reproductive toxicity	1109 mg/kg bw	reproductive toxicity rat oral	Regulatory source p.26 SCCS Opinion
Silver Zinc Zeolite 130328-20-0	reproductive toxicity	2011	reproductive toxicity oral developmental	Regulatory source p.26 SCCS Opinion
codes ........................................................... 12 7440-22-4	NOAEL	0.0045 mg/kg bw/d	rat oral 12 months	Regulatory source p.30 SCCS Opinion
codes ........................................................... 12 7440-22-4	NOAEL	0.0045 mg/kg bw/d	rat oral 12 months	Regulatory source p.30 SCCS Opinion
codes ........................................................... 12 7440-22-4	NOAEL	0.0045 mg/kg bw/d	rat oral 12 months	Regulatory source p.30 SCCS Opinion
codes ........................................................... 12 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 9-year	SCCS Opinion p.25 SCCS Opinion
codes ........................................................... 12 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 9-year	SCCS Opinion p.25 SCCS Opinion
codes ........................................................... 12 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 9-year	SCCS Opinion p.25 SCCS Opinion
codes ........................................................... 12 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 9-year	SCCS Opinion p.25 SCCS Opinion
codes ........................................................... 12 7440-22-4	repeated dose toxicity	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 9-year	Regulatory source p.25 SCCS Opinion
codes ........................................................... 12 7440-22-4	repeated dose toxicity	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 9-year	Regulatory source p.25 SCCS Opinion
codes ........................................................... 12 7440-22-4	repeated dose toxicity	0.0045 mg/kg bw/d	repeated dose toxicity rat chronic	Regulatory source p.33 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.0045 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.25 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.25 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.25 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion
7440-22-4 7440-22-4	NOAEL	0.25 mg/kg bw/d	repeated dose toxicity rat oral 12 months	SCCS Opinion p.25 SCCS Opinion

Safety Conclusion

sccs_opinions Max Spray deodorant: 1% (max 2.5% silver content); Powder foundation: 1% (max 2.5% silver content)

Safe with restrictions — safe only in spray deodorant and powder foundation at specified concentration

Key concerns: Toxic for reproduction Cat. 2 (zinc); argyria risk (silver); inhalation concern for sprays addressed by insolubility of particles

Opinion date: 21 December 2023

safety_opinions

unknown

Opinion date: 21 December 2023

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en