SCCS/0881/05 12 NOAEL rows Safety conclusion

Glyoxal (INCI name), Glyoxal

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/0881/05.

Opinion Number

SCCS/0881/05

NOAEL Rows

12

Substances Covered

2

Substance(s) Covered

Glyoxal (INCI name) Glyoxal

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38
Glyoxal (INCI name) 107-22-2	NOAEL	5 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.38
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46
Glyoxal (INCI name) 107-22-2	NOAEL	25 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46
Glyoxal (INCI name) 107-22-2	NOAEL	125 mg/kg bw	repeated dose toxicity prenatal	SCCS Opinion p.46

Safety Conclusion

sccs_opinions Max 1.0%

safe

Key concerns: secondary amine; nitrosamine <50ppb; sensitisation not excluded

Opinion date: 17 March 2006

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en