SCCS/1365/10 4 NOAEL rows Safety conclusion

1,5-Naphthalenediol

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1365/10.

Opinion Number
SCCS/1365/10
NOAEL Rows
4
Substances Covered
1

Substance(s) Covered

1,5-Naphthalenediol

NOAEL Values Extracted from This Opinion

Substance Endpoint Value Study Source
83-56-7
83-56-7
 NOAEL 360 mg/kg bw/day NOAEL study
human
SCCS Opinion
p.20
83-56-7
83-56-7
 NOAEL 360 mg/kg bw/day NOAEL study
human
SCCS Opinion
p.20
83-56-7
83-56-7
 NOAEL 360 mg/kg bw/day NOAEL study
human
SCCS Opinion
p.20
83-56-7
83-56-7
 NOAEL 360 mg/kg bw/day NOAEL study
human
SCCS Opinion
p.20

Safety Conclusion

sccs_opinions Max 1%
The SCCP is of the opinion that 1,5-Naphthalenediol as an ingredient in oxidative and non-oxidative hair dye formulations at a maximum on-head concentration of 1% does not pose a risk to the health of the consumer, apart from its sensitising potential.

Key concerns: Sensitising potential. No mutagenic potential in vivo; genotoxicity/mutagenicity studies in finished formulations should be undertaken per SCCNFP/SCCP opinions and Notes of Guidance.

Opinion date: 21 September 2010

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en