SCCS/1591/17 58 NOAEL rows Safety conclusion

Butylphenyl methylpropional (p-BMHCA) - Submission II

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1591/17.

Opinion Number

SCCS/1591/17

NOAEL Rows

Substances Covered

Substance(s) Covered

Butylphenyl methylpropional (p-BMHCA) - Submission II

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
80-54-6 80-54-6	NOAEL	0.0281 mg/kg bw	rat oral	Regulatory source p.48 SCCS Opinion
80-54-6 80-54-6	NOAEL	0.0281 mg/kg bw	rat oral	Regulatory source p.48 SCCS Opinion
80-54-6 80-54-6	NOAEL	50 %	human oral	Regulatory source p.52 SCCS Opinion
80-54-6 80-54-6	NOAEL	50 %	human oral	Regulatory source p.52 SCCS Opinion
80-54-6 80-54-6	NOAEL	0.0281 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.48 SCCS Opinion
80-54-6 80-54-6	NOAEL	0.0281 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.48 SCCS Opinion
80-54-6 80-54-6	NOAEL	0.0281 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.48 SCCS Opinion
80-54-6 80-54-6	NOAEL	0.0281 mg/kg bw	NOAEL study rat oral	SCCS Opinion p.48 SCCS Opinion
80-54-6 80-54-6	NOAEL	40 mg/kg bw/day	developmental toxicity rat 2 weeks	SCCS Opinion p.35 SCCS Opinion
80-54-6 80-54-6	NOAEL	40 mg/kg bw/day	developmental toxicity rat 2 weeks	SCCS Opinion p.35 SCCS Opinion
80-54-6 80-54-6	NOAEL	40 mg/kg bw/day	developmental toxicity rat 2 weeks	SCCS Opinion p.35 SCCS Opinion
80-54-6 80-54-6	NOAEL	40 mg/kg bw/day	developmental toxicity rat 2 weeks	SCCS Opinion p.35 SCCS Opinion
80-54-6 80-54-6	developmental toxicity	10 mg/kg bw/d	developmental toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	developmental toxicity	10 mg/kg bw/d	developmental toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	developmental toxicity	10 mg/kg bw/d	developmental toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	developmental toxicity	10 mg/kg bw/d	developmental toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	developmental toxicity	40 mg/kg bw/day	developmental toxicity rat 2 weeks	Regulatory source p.35 SCCS Opinion
80-54-6 80-54-6	developmental toxicity	40 mg/kg bw/day	developmental toxicity rat 2 weeks	Regulatory source p.35 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	4.5 mg/kg bw/d	repeated dose toxicity rat oral developmental	Regulatory source p.41 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	4.5 mg/kg bw/d	repeated dose toxicity rat oral developmental	Regulatory source p.41 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	5 mg/kg bw/day	repeated dose toxicity rat oral 90 days	Regulatory source p.20 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	5 mg/kg bw/day	repeated dose toxicity rat 2 weeks	Regulatory source p.35 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	5 mg/kg bw/day	repeated dose toxicity rat 2 weeks	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	5 mg/kg bw/day	repeated dose toxicity rat oral 90 days	Regulatory source p.20 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	5 mg/kg bw/day	repeated dose toxicity rat 2 weeks	Regulatory source p.35 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	5 mg/kg bw/day	repeated dose toxicity rat 2 weeks	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	25 mg/kg bw/day	repeated dose toxicity rat 5 days	Regulatory source p.34 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	25 mg/kg bw/day	repeated dose toxicity rat oral 5 days	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	25 mg/kg bw/day	repeated dose toxicity rat 5 days	Regulatory source p.34 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	25 mg/kg bw/day	repeated dose toxicity rat oral 5 days	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	40 mg/kg bw/day	repeated dose toxicity rat 5 days	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	40 mg/kg bw/day	repeated dose toxicity rat 5 days	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	45 mg/kg bw/d	repeated dose toxicity rat Developmental	Regulatory source p.41 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	45 mg/kg bw/d	repeated dose toxicity rat Developmental	Regulatory source p.41 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	50 mg/kg bw/day	repeated dose toxicity rat oral subacute	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	repeated dose toxicity	50 mg/kg bw/day	repeated dose toxicity rat oral subacute	Regulatory source p.49 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	4.5 mg/kg bw/d	reproductive toxicity developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	4.5 mg/kg bw/d	reproductive toxicity developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral	Regulatory source p.50 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.50 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.50 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rabbit oral developmental	Regulatory source p.50 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity developmental	Regulatory source p.40 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rat oral	Regulatory source p.50 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.50 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity oral developmental	Regulatory source p.50 SCCS Opinion
80-54-6 80-54-6	reproductive toxicity	10 mg/kg bw/d	reproductive toxicity rabbit oral developmental	Regulatory source p.50 SCCS Opinion

Safety Conclusion

sccs_opinions Max N/A (banned from EU cosmetics)

Not safe (aggregate exposure MoS <100); banned in EU cosmetics from March 2022

Key concerns: Aggregate exposure exceeds safe threshold; skin sensitisation; CMR 1B (H360FD) reproductive toxicity; mutagenicity concerns

Opinion date: 10 May 2019

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en