SCCS/1625/20 63 NOAEL rows Safety conclusion

, and this warrants further, Benzophenone-3

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1625/20.

Opinion Number

SCCS/1625/20

NOAEL Rows

Substances Covered

Substance(s) Covered

, and this warrants further Benzophenone-3

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
, and this warrants further 131-57-7	NOAEL	0.5 %	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	3	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	6 %	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	6 %	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	6 %	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	6 %	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	6 %	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	6 %	Not recorded	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	62	Not recorded	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	67.9 mg/kg bw/d	oral	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	67.9 mg/kg bw/d	oral	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	67.9 mg/kg bw/d	oral	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	>99 %	mouse 5 weeks	Regulatory source p.40 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	364 mg/kg bw/day	mouse dermal	Regulatory source p.67 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	411 mg/kg/ day	rat oral 39 days	Regulatory source p.65 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	411 mg/kg/ day	rat oral	Regulatory source p.65 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1000 ppm	Not recorded	Regulatory source p.39 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1625	rat	Regulatory source p.48 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	3448.2 mg/kg/day	Not recorded	Regulatory source p.63 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1000 mg/kg bw/day	developmental toxicity rat oral Prenatal	SCCS Opinion p.62 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1000 mg/kg bw/day	developmental toxicity rat oral Prenatal	SCCS Opinion p.62 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1000 mg/kg bw/day	developmental toxicity rat oral Prenatal	SCCS Opinion p.62 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1000 mg/kg bw/day	developmental toxicity rat oral Prenatal	SCCS Opinion p.62 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1625	NOAEL study rat	SCCS Opinion p.48 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1625	NOAEL study rat	SCCS Opinion p.48 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1625	NOAEL study rat	SCCS Opinion p.48 SCCS Opinion
, and this warrants further 131-57-7	NOAEL	1625	NOAEL study rat	SCCS Opinion p.48 SCCS Opinion
, and this warrants further 131-57-7	dermal absorption	67.9 mg/kg bw/d	dermal absorption dermal	Regulatory source p.51 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	6 %	developmental toxicity rat oral prenatal	Regulatory source p.47 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	200 mg/kg bw/d	developmental toxicity rat oral	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	200 mg/kg bw/d	developmental toxicity rat oral	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	200 mg/kg bw/d	developmental toxicity mouse oral 2 years	Regulatory source p.64 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	200 mg/kg bw/d	developmental toxicity mouse oral 2 years	Regulatory source p.64 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	200 mg/kg bw/d	developmental toxicity mouse oral 2 years	Regulatory source p.64 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	200 mg/kg bw/d	developmental toxicity rat oral Prenatal	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	242 mg/kg bw/d	developmental toxicity rat oral	Regulatory source p.63 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	242 mg/kg bw/d	developmental toxicity rat oral	Regulatory source p.63 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	242 mg/kg bw/d	developmental toxicity rat oral	Regulatory source p.63 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	660 mg/kg	developmental toxicity rat oral 105 weeks	Regulatory source p.64 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	1000 mg/kg bw/day	developmental toxicity rat oral Prenatal	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	1000 ppm	developmental toxicity rat oral	Regulatory source p.63 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	1000 mg/kg bw/day	developmental toxicity rat oral Prenatal	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	3000 ppm	developmental toxicity developmental	Regulatory source p.27 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	3000 ppm	developmental toxicity developmental	Regulatory source p.27 SCCS Opinion
, and this warrants further 131-57-7	developmental toxicity	3689 mg/kg	developmental toxicity rat oral	Regulatory source p.63 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	1 %	repeated dose toxicity rat oral Sub-chronic	Regulatory source p.66 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	100 mg/kg bw/day	repeated dose toxicity rat oral Sub-chronic	Regulatory source p.66 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	100 mg/kg bw/day	repeated dose toxicity rat oral Sub-chronic	Regulatory source p.66 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	200 mg/kg bw/day	repeated dose toxicity rat oral 90d	Regulatory source p.25 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	200 mg/kg bw/day	repeated dose toxicity rat oral developmental	Regulatory source p.50 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	200 mg/kg bw/day	repeated dose toxicity rat oral developmental	Regulatory source p.50 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	200 mg/kg bw/day	repeated dose toxicity rat dermal Sub-chronic	Regulatory source p.67 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	200 mg/kg bw/day	repeated dose toxicity rat dermal Sub-chronic	Regulatory source p.67 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	200 mg/kg bw/day	repeated dose toxicity rat dermal Sub-chronic	Regulatory source p.67 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	364 mg/kg bw/day	repeated dose toxicity rat dermal Sub-chronic	Regulatory source p.67 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	411 mg/kg bw/day	repeated dose toxicity rat oral 90d	Regulatory source p.25 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	1246 mg/kg bw /day	repeated dose toxicity rat oral Sub-chronic	Regulatory source p.67 SCCS Opinion
, and this warrants further 131-57-7	repeated dose toxicity	50000 ppm	repeated dose toxicity mouse oral Sub-chronic	Regulatory source p.67 SCCS Opinion
, and this warrants further 131-57-7	reproductive toxicity	0 ppm	reproductive toxicity	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	reproductive toxicity	0 ppm	reproductive toxicity rat	Regulatory source p.62 SCCS Opinion
, and this warrants further 131-57-7	reproductive toxicity	200 mg/kg bw/day	reproductive toxicity rat Chronic	Regulatory source p.26 SCCS Opinion
, and this warrants further 131-57-7	reproductive toxicity	200 mg/kg bw/day	reproductive toxicity rat Chronic	Regulatory source p.26 SCCS Opinion
, and this warrants further 131-57-7	reproductive toxicity	1000 ppm	reproductive toxicity rat dermal	Regulatory source p.51 SCCS Opinion

Safety Conclusion

sccs_opinions Max 6% in face cream, hand cream, lipstick; 2.2% in body cream and spray products; 0.5% as product formulation protectant

safe with restrictions

Key concerns: Potential endocrine disrupting properties; systemic absorption concerns at full-body application; photostability concerns; restricted due to insufficient MoS for body application

Opinion date: 30-31 March 2021

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en