Moderate Cosmetic Ingredient NOAEL Data

BENZOPHENONE-3

CAS Number
131-57-7
Function
Light Stabilizer, Uv Absorber, Uv Filter
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Restricted
EU Max Conc. VI/4
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR: S - JACT 2(5):35-77, 1983

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Toxicological Studies

7 study endpoints found for BENZOPHENONE-3. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 240 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 544 mg/kg bw/day oral mouse Subchronic COSMOS_DB
LOAEL 1248 mg/kg bw/day oral mouse Subchronic COSMOS_DB
NOAEL 6250 ppm oral rat oral REACH
NOAEL 200 mg/kg bw/day dermal code:3544 dermal REACH
NOAEL 25000 ppm oral mouse oral REACH
NOAEL >10000 ppm oral rat oral REACH

Expert Verdict

BENZOPHENONE-3 is listed in the EU CosIng database with functions: Light Stabilizer, Uv Absorber, Uv Filter It is restricted under EU Cosmetics Regulation. Restriction: VI/4.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted uv-filter needs-enrichment ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is BENZOPHENONE-3 safe in cosmetics?

BENZOPHENONE-3 is listed in the EU CosIng database with functions: Light Stabilizer, Uv Absorber, Uv Filter It is restricted under EU Cosmetics Regulation. Restriction: VI/4. The EU classifies BENZOPHENONE-3 as "Restricted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.

Is BENZOPHENONE-3 allowed in the EU?

BENZOPHENONE-3 EU regulatory status: Restricted. Maximum allowed concentration: VI/4. This is based on EU Regulation 1223/2009 and its amendments.

What does BENZOPHENONE-3 do in cosmetics?

BENZOPHENONE-3 functions as: Light Stabilizer, Uv Absorber, Uv Filter. It is classified as a cosmetic ingredient in our database. CAS number: 131-57-7.

What is the NOAEL for BENZOPHENONE-3?

The NOAEL (No Observed Adverse Effect Level) for BENZOPHENONE-3 is 240 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.

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