SCCS/1671/24 12 NOAEL rows Safety conclusion

Ethylhexyl Methoxycinnamate (EHMC), Opinion on

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1671/24.

Opinion Number

SCCS/1671/24

NOAEL Rows

Substances Covered

Substance(s) Covered

Ethylhexyl Methoxycinnamate (EHMC) Opinion on

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	450 mg/kg bw/day	NOAEL study	SCCS Opinion p.46 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	450 mg/kg bw/day	NOAEL study	SCCS Opinion p.46 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	450 mg/kg bw/day	NOAEL study	SCCS Opinion p.46 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	450 mg/kg bw/day	NOAEL study	SCCS Opinion p.46 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	900 mg/kg bw/day	NOAEL study rat dermal	SCCS Opinion p.43 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	900 mg/kg bw/day	NOAEL study rat dermal	SCCS Opinion p.43 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	900 mg/kg bw/day	NOAEL study rat dermal	SCCS Opinion p.43 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	900 mg/kg bw/day	NOAEL study rat dermal	SCCS Opinion p.43 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	1500 mg/kg bw/day	NOAEL study rat	SCCS Opinion p.44 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	1500 mg/kg bw/day	NOAEL study rat	SCCS Opinion p.44 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	1500 mg/kg bw/day	NOAEL study rat	SCCS Opinion p.44 SCCS Opinion
Ethylhexyl Methoxycinnamate (EHMC) 5466-77-3	NOAEL	1500 mg/kg bw/day	NOAEL study rat	SCCS Opinion p.44 SCCS Opinion

Safety Conclusion

sccs_opinions Max up to 10%

safe with restrictions

Key concerns: Endocrine-active substance (estrogenic activity and weak anti-androgenic activity in vitro and in vivo); environmental safety not assessed

Opinion date: 26 June 2025

safety_opinions general Max 10

safe

otential endocrine disrupting properties of EHMC, the SCCS is of the opinion that EHMC is safe when used as a UV filter up to a maximum concentration of 10% in sunscreen lotion, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination.

Opinion date: 26 June 2025

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en