Moderate Active Ingredient SCCS/CIR Reviewed

Octinoxate

INCI: ETHYLHEXYL METHOXYCINNAMATE

CAS Number
5466-77-3
Function
Oil-soluble UVB UV filter; peak absorption ~311 nm; undergoes trans-to-cis photoisomerization under UV exposure causing progressive SPF loss
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 10%
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Historically marketed in the US; FDA states existing data is not sufficient to determine GRASE. Regulatory limbo alongside seven other chemical filters. Banned by local legislation in Hawaii (2021), US Virgin Islands, and other coastal jurisdictions due to coral reef toxicity. Final GRASE determination pending additional safety data.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

sccs SCCS/1671/24 26 June 2025
Verdict: safe
NOAEL: 450 mg/kg bw/day (oral)
Max Concentration: 10% in general

otential endocrine disrupting properties of EHMC, the SCCS is of the opinion that EHMC is safe when used as a UV filter up to a maximum concentration of 10% in sunscreen lotion, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination.

sccs SCCS/1671/24 26 June 2025
Verdict: safe
NOAEL: 450 mg/kg bw/day (oral)
Max Concentration: 10% in spray/aerosol

otential endocrine disrupting properties of EHMC, the SCCS is of the opinion that EHMC is safe when used as a UV filter up to a maximum concentration of 10% in sunscreen lotion, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination.

sccs SCCS/1671/24 26 June 2025
Verdict: safe
NOAEL: 450 mg/kg bw/day (not specified)
Max Concentration: 10% in general

otential endocrine disrupting properties of EHMC, the SCCS is of the opinion that EHMC is safe when used as a UV filter up to a maximum concentration of 10% in sunscreen lotion, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination.

sccs SCCS/1671/24 26 June 2025
Verdict: safe
NOAEL: 450 mg/kg bw/day (not specified)
Max Concentration: 10% in spray/aerosol

otential endocrine disrupting properties of EHMC, the SCCS is of the opinion that EHMC is safe when used as a UV filter up to a maximum concentration of 10% in sunscreen lotion, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination.

sccs SCCS/1671/24 26 June 2025
Verdict: safe
NOAEL: 1000 mg/kg bw/day (not specified)
Max Concentration: 10% in general

otential endocrine disrupting properties of EHMC, the SCCS is of the opinion that EHMC is safe when used as a UV filter up to a maximum concentration of 10% in sunscreen lotion, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination.

Expert Verdict

One of the most globally used UVB filters; SCCS 2025 confirmed safety at โ‰ค10% including for children with 1-2% dermal absorption and high margin of safety despite confirmed endocrine-disrupting and anti-androgenic properties. US remains in regulatory limbo; banned in Hawaii, US Virgin Islands, Palau, and 20+ coastal jurisdictions for coral reef toxicity. Photounstable trans-to-cis isomerization reduces SPF and generates potential sensitizers over time. EU-permitted but formulators face growing substitution pressure from reef-ban expansion and endocrine concerns.

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Concern Level: Moderate

Regulatory Flags

uv-filter uvb oil-soluble photounstable trans-cis-isomerization fda-limbo systemic-absorption endocrine-disruption-concern anti-androgenic reef-toxic banned-hawaii banned-palau banned-us-virgin-islands coral-bleaching photocontact-allergen sccs-2025-safe-at-10pct ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is Octinoxate safe in cosmetics?

One of the most globally used UVB filters; SCCS 2025 confirmed safety at โ‰ค10% including for children with 1-2% dermal absorption and high margin of safety despite confirmed endocrine-disrupting and anti-androgenic properties. US remains in regulatory limbo; banned in Hawaii, US Virgin Islands, Palau, and 20+ coastal jurisdictions for coral reef toxicity. Photounstable trans-to-cis isomerization reduces SPF and generates potential sensitizers over time. EU-permitted but formulators face growing substitution pressure from reef-ban expansion and endocrine concerns. The EU classifies Octinoxate as "permitted". Safety rating: MODERATE. This ingredient has been reviewed by sccs.

Is Octinoxate allowed in the EU?

Octinoxate EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.

What does Octinoxate do in cosmetics?

Octinoxate functions as: Oil-soluble UVB UV filter; peak absorption ~311 nm; undergoes trans-to-cis photoisomerization under UV exposure causing progressive SPF loss. It is classified as a Active Ingredient in our database. CAS number: 5466-77-3.

What is the Margin of Safety for Octinoxate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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