What is the NOAEL for Anisole?
Anisole has 28 NOAEL studies in the database. The lowest reported value is 20 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Anisole
Also known as: Benzene, methoxy, EINECS 202-876-1, Ether, methyl phenyl, FEMA No. 2097, FEMA Number 2097 (+8 more)
CAS 100-66-3
Anisole (CAS 100-66-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
28
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Anisole
CAS Number
100-66-3
DTXSID
DTXSID4041608
Molecular Formula
C7H8O
InChI Key
RDOXTESZEPMUJZ-UHFFFAOYSA-N
Monoisotopic Mass
108.057515
Synonyms
Benzene, methoxyEINECS 202-876-1Ether, methyl phenylFEMA No. 2097FEMA Number 2097UNII-B3W693GAZHAnisolAnisole, 8CIAnizolHSDB 44Methoxy-BenzeneMethoxy-benzene (anisol)
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 28 of 28 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =20 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| B3W693GAZH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B3W693GAZH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B3W693GAZH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B3W693GAZH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >6.51 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =3700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =118.3 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =1500 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| 1230 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =5.7 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =5.7 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| >32 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v52je16 |
| >32 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =40 | mg/kg bw/day | NOEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =40 | mg/kg bw/day | NOEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =120 | mg/kg bw/day | NOEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =120 | mg/kg bw/day | NOEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =196 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =196 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v52je16 |
| >250 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| >250 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =300 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v52je16 |
| =300 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v52je16 |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 28 of 28 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Anisole | 202-876-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ANISOLE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Anisole?
Anisole appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Anisole used in cosmetics?
Yes, Anisole is also indexed as a cosmetic ingredient under the name Anisole (Methoxybenzene). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Anisole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Anisole used outside industrial chemicals?
Anisole also appears in cosmetics, pharmaceutical, food safety, cannabis databases.