Is Anisole (Methoxybenzene) safe in cosmetics?
Anisole (Methoxybenzene) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Anisole (Methoxybenzene)
Also known as: Benzene, methoxy, EINECS 202-876-1, Ether, methyl phenyl, FEMA No. 2097, FEMA Number 2097 (+8 more)
INCI: ANISOLE
Anisole (Methoxybenzene) (CAS 100-66-3) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 100-66-3 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; RIFM safety assessment confirms safe use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Anisole (Methoxybenzene).
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Anisole (Methoxybenzene).
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Anisole (Methoxybenzene) by CAS number or substance name.
Studies
3
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Benzene, methoxy
EINECS 202-876-1
Ether, methyl phenyl
FEMA No. 2097
FEMA Number 2097
UNII-B3W693GAZH
Anisol
Anisole, 8CI
Anizol
HSDB 44
Methoxy-Benzene
Methoxy-benzene (anisol)
Methyl phenyl-Ether
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ANISOLE
ChEMBL ID
CHEMBL278024
Frequently Asked Questions
Is Anisole (Methoxybenzene) allowed in the EU?
Anisole (Methoxybenzene) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Anisole (Methoxybenzene) do in cosmetics?
Anisole (Methoxybenzene) functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 100-66-3.
Is Anisole (Methoxybenzene) used outside cosmetics?
Anisole (Methoxybenzene) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Anisole (Methoxybenzene) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ANISOLE
Good
Chemical family
Perfuming
Anisic Acid
Good
Chemical family
Fragrance, Antimicrobial Preservation...
BENZALDEHYDE
Good
Chemical family
Denaturant, Flavouring, Fragrance, Pe...
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