Excellent Cosmetic Ingredient NOAEL Data GHS Classified

Anisole (Methoxybenzene)

INCI: ANISOLE

CAS Number
100-66-3
Function
Perfuming
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted by FDA; RIFM safety assessment confirms safe use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Anisole (Methoxybenzene). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1230 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 1230 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation.

Expert Verdict

Not genotoxic; not PBT; not phototoxic or photoallergenic; very low volume of use globally (<0.1 metric tons/year)

⚠️
Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Anisole (Methoxybenzene) safe in cosmetics?

Not genotoxic; not PBT; not phototoxic or photoallergenic; very low volume of use globally (<0.1 metric tons/year) The EU classifies Anisole (Methoxybenzene) as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Anisole (Methoxybenzene) allowed in the EU?

Anisole (Methoxybenzene) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Anisole (Methoxybenzene) do in cosmetics?

Anisole (Methoxybenzene) functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 100-66-3.

What is the Margin of Safety for Anisole (Methoxybenzene)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Anisole (Methoxybenzene)?

The NOAEL (No Observed Adverse Effect Level) for Anisole (Methoxybenzene) is 1230 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Anisole (Methoxybenzene) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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