Food Safety Substance
Anisole
Anisole is a food additive with PUBLISHED in the EU, FDA EAFUS in the US, and data from 9 regulatory sources.
CAS 100-66-3
Indexable evidence set
FDA
FDA EAFUS
ADI / TDI
EFSA ADI = 1 mg/kg bw
Codex
32 row(s)
SOURCE
D1 identity resolution
e number aliases | Food Additives | dsstox identifiers | 9 matched regulatory source group(s)
Substance Identity
Resolved identifiers used to render this food-safety record.
Substance name
Anisole
CAS
100-66-3
DTXSID
DTXSID4041608
PubChem CID
7519
Evidence tier
Indexable evidence set (16)
SOURCE
EU Commission
FDA | Health Canada | Codex Alimentarius
Multi-Jurisdiction Comparison
Side-by-side status rows for the same resolved substance across public food regulators.
| Jurisdiction | Authority | Status | Evidence |
|---|---|---|---|
| European Union | EU Commission | PUBLISHED | EU additive listing; Annex II entry |
| Canada | Health Canada | Listed | Preservative |
| Codex | Codex Alimentarius | Listed | Antioxidant |
SOURCE
EU Commission
EU Food Additives | EU Food Additives Database
EU Food Additive Status
EU Commission food-additive listing rows from eu_food_additives.
| Jurisdiction | E-number | Status | Type | Name | Note |
|---|---|---|---|---|---|
| European Union | E320 | PUBLISHED | substanceFAD | Butylated hydroxyanisole (BHA) | - |
SOURCE
EU Commission
EU Annex II Authorised | EU Food Additives Database
EU Annex II Authorised Uses
Authorised additive rows and use conditions from EU Annex II tables.
| Jurisdiction | E-number | Name | INS | Policy item | Note |
|---|---|---|---|---|---|
| European Union | E320 | Butylated hydroxyanisole (BHA) | - | POL-FAD-IMPORT-3093 | - |
SOURCE
Codex Alimentarius
Codex GSFA
Codex GSFA Status
Codex Alimentarius GSFA permissions and maximum-use rows.
| Jurisdiction | INS / E-number | Function | Food category | Max level | Notes |
|---|---|---|---|---|---|
| Codex | 320 | Antioxidant | 01.3.2 Beverage whiteners | 100 mg/kg | Excluding products conforming to the Standard for a Blend of Sweetened Condensed Skimmed Milk and Vegetable Fat (CODEX STAN 252-2006).; On the fat or oil basis.; Singly or in... |
| Codex | 320 | Antioxidant | 01.5.1 Milk powder and cream powder (plain) | 100 mg/kg | Singly or in combination: butylated hydroxyanisole (BHA, INS 320), butylated hydroxytoluene (BHT, INS 321) and propyl gallate (INS 310).; On the fat or oil basis except for use in... |
| Codex | 320 | Antioxidant | 01.5.2 Milk and cream powder analogues | 100 mg/kg | On the fat or oil basis.; For use in products conforming to the Standard for a Blend of Skimmed Milk and Vegetable Fat in Powdered Form (CXS 251-2006), singly or in combination:... |
| Codex | 320 | Antioxidant | 02.1.1 Butter oil, anhydrous milkfat, ghee | 175 mg/kg | Excluding anhydrous milkfat.; Any combination of butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), and propyl gallate (INS 310) at 200 mg/kg, provided that... |
| Codex | 320 | Antioxidant | 02.1.2 Vegetable oils and fats | 200 mg/kg | Excluding products conforming to the Standard for Olive Oils and Olive Pomace Oils (CODEX STAN 33-1981).; Excluding products conforming to the Regional Standard for Unrefined Shea... |
| Codex | 320 | Antioxidant | 02.1.3 Lard, tallow, fish oil, and other animal fats | 200 mg/kg | On the fat or oil basis.; Except for use in products conforming to the Standard for Edible Fats and Oils not Covered by Individual Standards (CXS 19-1981) and the Standard for... |
| Codex | 320 | Antioxidant | 02.2.2 Fat spreads, dairy fat spreads and blended spreads | 200 mg/kg | Except for use in products conforming to the Standard for Dairy Fat Spreads (CXS 253-2006), only intended for cooking purposes: propyl gallate (INS 310) at 200 mg/kg, butylated... |
| Codex | 320 | Antioxidant | 02.3 Fat emulsions mainly of type oil-in-water, including mixed and/or flavoured products based on fat emulsions | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
| Codex | 320 | Antioxidant | 02.4 Fat-based desserts excluding dairy-based dessert products of food category 01.7 | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
| Codex | 320 | Antioxidant | 03.0 Edible ices, including sherbet and sorbet | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (BHA, INS 320), butylated hydroxytoluene (BHT, INS 321) and tertiary butylhydroquinone (TBHQ, INS 319). |
| Codex | 320 | Antioxidant | 04.2.2.2 Dried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (BHA, INS 320), butylated hydroxytoluene (BHT, INS 321) and propyl gallate (INS 310).; Except for... |
| Codex | 320 | Antioxidant | 05.1.4 Cocoa and chocolate products | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
| Codex | 320 | Antioxidant | 05.2 Confectionery including hard and soft candy, nougats, etc. other than food categories 05.1, 05.3 and 05.4 | 200 mg/kg | On the fat or oil basis.; Excluding products conforming to the Codex Regional Standard for Halawa Tehenia (CODEX STAN 309R-211).; Singly or in combination: butylated... |
| Codex | 320 | Antioxidant | 05.3 Chewing gum | 400 mg/kg | Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl gallate (INS 310). |
| Codex | 320 | Antioxidant | 05.4 Decorations (e.g. for fine bakery wares), toppings (non-fruit) and sweet sauces | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
| Codex | 320 | Antioxidant | 06.3 Breakfast cereals, including rolled oats | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (BHA, INS 320), butylated hydroxytoluene (BHT, INS 321) and propyl gallate (INS 310). |
| Codex | 320 | Antioxidant | 06.4.3 Pre-cooked pastas and noodles and like products | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
| Codex | 320 | Antioxidant | 07.0 Bakery wares | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (BHA, INS 320) and butylated hydroxytoluene (BHT, INS 321). |
| Codex | 320 | Antioxidant | 08.2 Processed meat, poultry, and game products in whole pieces or cuts | 200 mg/kg | On the fat or oil basis.; Excluding products conforming to the Standard for Cooked Cured Ham (CODEX STAN 96-1981).; Excluding products conforming to the Standard for Cooked Cured... |
| Codex | 320 | Antioxidant | 08.3 Processed comminuted meat, poultry, and game products | 200 mg/kg | Excluding products conforming to the Standard for Corned Beef (CODEX STAN 88-1981).; On the fat or oil basis.; Excluding products conforming to the Standard for Cooked Cured... |
| Codex | 320 | Antioxidant | 09.2.1 Frozen fish, fish fillets, and fish products, including mollusks, crustaceans, and echinoderms | 200 mg/kg | Excluding products conforming to the Standard for Quick Frozen Shrimps and Prawns (CODEX STAN 92-1981).; Excluding products conforming to the Standard for Quick Frozen Raw Squid... |
| Codex | 320 | Antioxidant | 09.2.2 Frozen battered fish, fish fillets, and fish products, including mollusks, crustaceans, and echinoderms | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (BHA, INS 320) and butylated hydroxytoluene (BHT, INS 321).; Excluding products conforming to the... |
| Codex | 320 | Antioxidant | 09.2.5 Smoked, dried, fermented, and/or salted fish and fish products, including mollusks, crustaceans, and echinoderms | 200 mg/kg | Excluding products conforming to the Standard for Salted Atlantic Herring and Salted Sprat (CODEX STAN 244-2004).; Excluding products conforming to the Standard for Crackers from... |
| Codex | 320 | Antioxidant | 09.3 Semi-preserved fish and fish products, including mollusks, crustaceans, and echinoderms | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (BHA, INS 320) and butylated hydroxytoluene (BHT, INS 321).; Excluding products conforming to the... |
| Codex | 320 | Antioxidant | 09.4 Fully preserved, including canned or fermented fish and fish products, including mollusks, crustaceans, and echinoderms | 200 mg/kg | Excluding products conforming to the Standard for Canned Salmon (CODEX STAN 3-1981).; Excluding products conforming to the Standard for Canned Crab Meat (CODEX STAN 90-1981).;... |
| Codex | 320 | Antioxidant | 12.2 Herbs, spices, seasonings and condiments (e.g. seasoning for instant noodles) | 200 mg/kg | Excluding products conforming to the SStandard for dried floral parts: Cloves (CXS 344-2021).; Excluding products conforming to the Standard for dried or dehydrated garlic (CXS... |
| Codex | 320 | Antioxidant | 12.5 Soups and broths | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
| Codex | 320 | Antioxidant | 12.6 Sauces and like products | 200 mg/kg | Except for use at 100 mg/kg in products conforming to the Standard for Chili Sauce (CXS 306-2011).; On the fat or oil basis.; Excluding products conforming to the Standard for... |
| Codex | 320 | Antioxidant | 12.8 Yeast and like products | 200 mg/kg | On the fat or oil basis. |
| Codex | 320 | Antioxidant | 13.6 Food supplements | 400 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (BHA, INS 320), butylated hydroxytoluene (BHT, INS 321) and propyl gallate (INS 310). |
| Codex | 320 | Antioxidant | 15.1 Snacks - potato, cereal, flour or starch based (from roots and tubers, pulses and legumes) | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
| Codex | 320 | Antioxidant | 15.2 Processed nuts, including coated nuts and nut mixtures (with e.g. dried fruit) | 200 mg/kg | On the fat or oil basis.; Singly or in combination: butylated hydroxyanisole (INS 320), butylated hydroxytoluene (INS 321), tertiary butylated hydroquinone (INS 319), and propyl... |
SOURCE
Health Canada
Health Canada Status
Health Canada food-additive permissions by functional class and food scope.
| Jurisdiction | Class | Permitted foods | Maximum level | List |
|---|---|---|---|---|
| Canada | Preservative | (a)Active dry yeasts | (a)1,000 ppm | List of Permitted Preservatives |
| Canada | Preservative | (b)Calorie-reduced margarine; Margarine | (b)If used singly, the amount not to exceed 0.01% of the fat content. If used in combination with butylated hydroxytoluene or propyl gallate, or both, the total combined amount not to exceed 0.01% of the fat content. | List of Permitted Preservatives |
| Canada | Preservative | (c)Chewing gum | (c)If used singly, the amount not to exceed 200 ppm. If used in combination with butylated hydroxytoluene or propyl gallate, or both, the total combined amount not to exceed 200 ppm. | List of Permitted Preservatives |
| Canada | Preservative | (d)Citrus oil flavours; Dry flavours; Essential oils | (d)If used singly, the amount not to exceed 1,250 ppm. If used in combination with butylated hydroxytoluene or propyl gallate, or both, the total combined amount not to exceed 1,250 ppm. | List of Permitted Preservatives |
| Canada | Preservative | (e)Citrus oils | (e)If used singly, the amount not to exceed 5,000 ppm. If used in combination with butylated hydroxytoluene or propyl gallate, or both, the total combined amount not to exceed 5,000 ppm. | List of Permitted Preservatives |
| Canada | Preservative | (f)Dehydrated potato products; Dried breakfast cereals | (f)If used singly, the amount not to exceed 50 ppm. If used in combination with butylated hydroxytoluene or propyl gallate, or both, the total combined amount not to exceed 50 ppm. | List of Permitted Preservatives |
| Canada | Preservative | (g)Dried cooked poultry meat | (g)If used singly, the amount not to exceed 0.015% of the fat content. If used in combination with citric acid or propyl gallate, or both, the total combined amount not to exceed 0.015% of the fat content. | List of Permitted Preservatives |
| Canada | Preservative | (h)Dry beverage mixes; Dry confectionery mixes; Dry dessert mixes | (h)90 ppm | List of Permitted Preservatives |
| Canada | Preservative | (i)Dry Vitamin D preparations for addition to food | (i)10 mg/1,000,000 I.U. | List of Permitted Preservatives |
| Canada | Preservative | (j)Fats and oils, except milk fat, olive oil and suet; Lard; Shortening | (j)If used singly, the amount not to exceed 200 ppm. If used in any combination with butylated hydroxytoluene, propyl gallate or tertiary butyl hydroquinone, the total combined amount not to exceed 200 ppm. | List of Permitted Preservatives |
| Canada | Preservative | (k)Partially defatted beef fatty tissue; Partially defatted pork fatty tissue | (k)If used singly, the amount not to exceed 65 ppm. If used in combination with butylated hydroxytoluene, the total combined amount not to exceed 65 ppm. | List of Permitted Preservatives |
| Canada | Preservative | (l)Vitamin A liquids for addition to food | (l)5 mg/1,000,000 I.U. | List of Permitted Preservatives |
| Canada | Preservative | (m)Unstandardized foods, except unstandardized preparations of meat or meat by-product, fish or meat (as defined in section B.21.002 of the *Food and Drug Regulations*) or poultry meat or poultry meat by-product and... | (m)If used singly, the amount not to exceed 0.02% of the fat content. If used in combination with butylated hydroxytoluene or propyl gallate, or both, the total combined amount not to exceed 0.02% of the fat content. | List of Permitted Preservatives |
SOURCE
EU Commission
EU Food Contact Materials
EU FCM Substances
EU food-contact material rows and migration-limit fields.
| Jurisdiction | FCM no. | Ref no. | Substance | Use | SML | Regulation |
|---|---|---|---|---|---|---|
| European Union | 635 | 40720 | tert-butyl-4-hydroxyanisole | additive/PPA | 30 mg/kg | Regulation (EU) No 10/2011, Annex I |
SOURCE
JECFA
JECFA ADI
JECFA ADI Values
JECFA ADI records and evaluation years.
| Jurisdiction | Chemical name | JECFA no. | CAS | ADI | ADI upper | Function | Evaluation year |
|---|---|---|---|---|---|---|---|
| JECFA | 4-ACETYLANISOLE | - | - | no_data | - | - | 2023 |
| JECFA | p-ACETYLANISOLE | - | - | no_data | - | - | 2023 |
| JECFA | o-HYDROXYANISOLE | - | - | no_data | - | - | 2000 |
| JECFA | o-ACETOXYANISOLE | - | - | no_data | - | - | 2000 |
| JECFA | p-METHYLANISOLE | 1243 | - | No safety concern at current levels of intake when used as a flavouring agent | - | FLAVOURING_AGENT | 2003 |
| JECFA | ACETANISOLE | 810 | - | No safety concern at current levels of intake when used as a flavouring agent | - | FLAVOURING_AGENT | 2023 |
| JECFA | BUTYLATED HYDROXYANISOLE | - | 25013-16-5 | 0-0.5 mg/kg bw | 0.5 | ANTIOXIDANT | 1988 |
| JECFA | ANISOLE | 1241 | - | No safety concern at current levels of intake when used as a flavouring agent | - | FLAVOURING_AGENT | 2003 |
| JECFA | 5-PROPYL-o-HYDROXYANISOLE | - | - | no_data | - | - | 2000 |
| JECFA | trans-p-PROPENYLANISOLE | - | - | no_data | - | - | 1998 |
| JECFA | m-METHOXYANISOLE | - | - | no_data | - | - | 2003 |
| JECFA | 2-ISOPROPYL-5-METHYLANISOLE | - | - | no_data | - | - | 2003 |
| JECFA | 2-ETHOXY-5-PROPENYLANISOLE | - | - | no_data | - | - | 2003 |
| JECFA | THIOANISOLE | - | - | no_data | - | - | 1999 |
| JECFA | p-PROPYLANISOLE | 1244 | 104-45-0 | No safety concern at current levels of intake when used as a flavouring agent | - | FLAVOURING_AGENT | 2003 |
| JECFA | o-METHYLANISOLE | 1242 | - | No safety concern at current levels of intake when used as a flavouring agent | - | FLAVOURING_AGENT | 2003 |
| JECFA | 2,4-DIMETHYLANISOLE | 1245 | - | No safety concern at current levels of intake when used as a flavouring agent | - | FLAVOURING_AGENT | 2008 |
| JECFA | 2-MERCAPTOANISOLE | 1666 | - | No safety concern at current levels of intake when used as a flavouring agent | - | FLAVOURING_AGENT | 2007 |
SOURCE
ingredients
ghs classifications
Cross-Reference to Cosmetics / Chemicals / Pharma
Same-CAS public rows from adjacent Roots verticals where available.
SOURCE
Cross-vertical comparison
ingredients | ghs classifications
Cross-Vertical Regulatory Divergence
This substance has different regulatory treatment across food, cosmetics, and industrial use.
SOURCE
FAQPage JSON-LD
public food renderer rows
Frequently Asked Questions
Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.
What is Anisole used for in food?
Anisole appears in food-use rows as: FLAVORING AGENT OR ADJUVANT; Antioxidant; Preservative.
Is Anisole safe?
This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: EFSA ADI = 1 mg/kg bw. EU status evidence: PUBLISHED. US/FDA evidence: FDA EAFUS.
What is the ADI for Anisole?
Anisole has this ADI/reference value in the food-safety tables: EFSA ADI = 1 mg/kg bw. Source: EFSA FEEDAP 2018.
Is Anisole also used in cosmetics?
Anisole has a same-CAS cosmetics cross-reference: Anisole (Methoxybenzene), EU status permitted.