What is the NOAEL for Citronellol?
Citronellol has 51 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Citronellol
Also known as: 3,7-Dimethyloct-6-en-1-ol, 6-Octen-1-ol, 3,7-dimethyl-, beta-Citronellol, 4-01-00-02188, BRN 1721507 (+6 more)
CAS 106-22-9
Citronellol (CAS 106-22-9) is a chemical substance. Key regulatory status: REACH registered, 43 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
51
SOURCE
chemical inventory jurisdictions
Regulatory lists
43
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Citronellol
CAS Number
106-22-9
DTXSID
DTXSID3026726
Molecular Formula
C10H20O
InChI Key
QMVPMAAFGQKVCJ-UHFFFAOYSA-N
Monoisotopic Mass
156.151415
Synonyms
3,7-Dimethyloct-6-en-1-ol6-Octen-1-ol, 3,7-dimethyl-beta-Citronellol4-01-00-02188BRN 1721507EINECS 203-375-0UNII-565OK72VNFEINECS 247-737-6Citronellol, dl-ElenolRhodinol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
43 records
| List | Keyword | Source |
|---|---|---|
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - body wash; Personal care - body hygiene - hand soap; Personal care - fragrance; Personal care - general moisturizing - hand/body lotion; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning; Cleaning products and household care - laundry and fabric treatment; detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 51 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 25.09 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 50.31 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 92.6 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =161.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 14.4 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 4000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 43.5 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| >2000 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| 47.9 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 54.1 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 65.4 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 66.1 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 69.6 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 70 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 73.5 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 74.4 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 83 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 565OK72VNF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 565OK72VNF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 565OK72VNF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 565OK72VNF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 375 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.39 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3724 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 29530 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =50 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| - | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 2 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 4.2 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 5.9 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 7.37 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 8.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 9.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 10.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 10.5 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 10.6 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 11 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 11.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 12.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 4.7 | % | Viability (18 hours) | Dermal | - | NTP_ICE_skin_irritation |
Showing 50 of 51 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Citronellol | 203-375-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off under Regulation (EU) 2023/1545; IFRA restrictions apply
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CITRONELLOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0-0.5 mg/kg bw (1979) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Citronellol?
Citronellol appears on 26 regulatory/inventory lists including air; Cleaning products and household care - air freshener; detected; emissions; Europe, Europe, inert_ingredient; non_food_use; Pesticides, and 23 more. Source: EPA CPDat.
Is Citronellol used in cosmetics?
Yes, Citronellol is also indexed as a cosmetic ingredient under the name Citronellol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Citronellol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Citronellol used outside industrial chemicals?
Citronellol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.